Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

Article

Quince, Zachery, Alonso-Caneiro, David, Read, Scott A., Harkin, Damien G. and Collins, Michael J.. 2024. "Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo." Biocybernetics and Biomedical Engineering. 44 (3), pp. 609-616. https://doi.org/10.1016/j.bbe.2024.08.006
Article Title

Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

ERA Journal ID211872
Article CategoryArticle
AuthorsQuince, Zachery, Alonso-Caneiro, David, Read, Scott A., Harkin, Damien G. and Collins, Michael J.
Journal TitleBiocybernetics and Biomedical Engineering
Journal Citation44 (3), pp. 609-616
Number of Pages8
Year2024
PublisherElsevier BV
Place of PublicationNetherlands
ISSN0208-5216
2391-467X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bbe.2024.08.006
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0208521624000597
Abstract

Significance
The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.
Aim
This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue.
Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.
Results
An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R2 = 0.274).
Conclusions
Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.

KeywordsAnimal model; Optical coherence elastography; Boundary segmentation
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020401099. Engineering practice and education not elsewhere classified
Byline AffiliationsSchool of Engineering
Queensland University of Technology
University of the Sunshine Coast
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