Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

Article

Quince, Zachery, Alonso-Caneiro, David, Read, Scott A., Harkin, Damien G. and Collins, Michael J.. 2024. "Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo." Biocybernetics and Biomedical Engineering. 44 (3), pp. 609-616. https://doi.org/10.1016/j.bbe.2024.08.006
Article Title

Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo

ERA Journal ID211872
Article CategoryArticle
AuthorsQuince, Zachery, Alonso-Caneiro, David, Read, Scott A., Harkin, Damien G. and Collins, Michael J.
Journal TitleBiocybernetics and Biomedical Engineering
Journal Citation44 (3), pp. 609-616
Number of Pages8
Year2024
PublisherElsevier BV
Place of PublicationNetherlands
ISSN0208-5216
2391-467X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bbe.2024.08.006
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0208521624000597
Abstract

Significance
The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.
Aim
This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue.
Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.
Results
An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R2 = 0.274).
Conclusions
Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.

KeywordsAnimal model; Optical coherence elastography; Boundary segmentation
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020400307. Mechanobiology
Byline AffiliationsSchool of Engineering
Queensland University of Technology
University of the Sunshine Coast
Permalink -

https://research.usq.edu.au/item/z9q16/static-compression-optical-coherence-elastography-for-the-measurement-of-porcine-corneal-mechanical-properties-ex-vivo

Log in to edit

Download files

Published Version
1-s2.0-S0208521624000597-main.pdf
License: CC BY 4.0
File access level: Anyone

  • 114
    total views
  • 4
    total downloads
  • 5
    views this month
  • 2
    downloads this month

Export as

Related outputs

A Lightweight Deep Learning Model for EEG Classification Across Visual Stimuli
Liu, Yi, Goh, Steven, Low, Tobias, Quince, Zach and Teragawa, Shoryu. 2024. "A Lightweight Deep Learning Model for EEG Classification Across Visual Stimuli." 27th International Conference on Computer Supported Cooperative Work in Design (CSCWD 2024 ). Tianjin, China 08 - 10 May 2024 United States. IEEE (Institute of Electrical and Electronics Engineers). https://doi.org/10.1109/CSCWD61410.2024.10580396
Happy Little Trees
Maxwell, Andrew, McAlister, Chris and Quince, Zachery. 2023. "Happy Little Trees." 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australia. Australasian Association for Engineering Education.
Educational Diversity in Engineering Entrance Pathways
Quince, Zach and Phythian, Mark. 2023. "Educational Diversity in Engineering Entrance Pathways." 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australia. Australasian Association for Engineering Education.
Rubrics – Know How to Use Them and How to Write Them
Quince, Zachery and Goh, Steven. 2023. "Rubrics – Know How to Use Them and How to Write Them." 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australasian Association for Engineering Education.
Trees of Convergency
Maxwell, Andrew, McAlister, Chris and Quince, Zach. 2023. "Trees of Convergency." 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australia. Australasian Association for Engineering Education.
Are engineering programs meeting the 2035 professional and personal requirements?
Quince, Zach, Hills, Catherine and Maxwell, Andrew. 2023. "Are engineering programs meeting the 2035 professional and personal requirements?" 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australia. Australasian Association for Engineering Education.
Orientation for Credit, Transition for Success
Hills, Catherine, McAlister, Chris, Kist, Alexander, Baillie, Justine, Quince, Zachery and Seligmann, Hannah. 2023. "Orientation for Credit, Transition for Success." 34th Annual Conference of the Australasian Association for Engineering Education (AAEE 2023). Gold Coast, Australia 03 - 06 Dec 2023 Australia. Australasian Association for Engineering Education.
Quantitative compressive optical coherence elastography using structural OCT imaging and optical palpation to measure soft contact lens mechanical properties
Quince, Zachery, Alonso-Caneiro, David, Read, Scott A. and Collins, Michael J.. 2022. "Quantitative compressive optical coherence elastography using structural OCT imaging and optical palpation to measure soft contact lens mechanical properties." Biomedical Optics Express. 12 (12), pp. 7315-7326. https://doi.org/10.1364/BOE.441547
Optical coherence elastography for the measurement of anterior segment biomechanical properties
Quince, Zachery David. 2022. Optical coherence elastography for the measurement of anterior segment biomechanical properties. PhD Thesis Doctor of Philosophy . Queensland University of Technology . https://doi.org/10.5204/thesis.eprints.236255
Static compression optical coherence elastography to measure the mechanical properties of soft contact lenses
Quince, Zachery, Alonso-Caneiro, David, Read, Scott A. and Collins, Michael J.. 2021. "Static compression optical coherence elastography to measure the mechanical properties of soft contact lenses." Biomedical Optics Express. 12 (4), pp. 1821-1833. https://doi.org/10.1364/BOE.419344