Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma
Article
Article Title | Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma |
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ERA Journal ID | 15690 |
Article Category | Article |
Authors | Memon, Muhammed Ashraf (Author), Subramanya, Manjunath S. (Author), Khan, Shahjahan (Author), Hossain, Md. Belal (Author), Osland, Emma (Author) and Memon, Breda (Author) |
Editors | Lillemoe, Keith D. |
Journal Title | Annals of Surgery |
Journal Citation | 253 (5), pp. 900-911 |
Number of Pages | 12 |
Year | 2011 |
Place of Publication | Philadelphia, PA. United States |
ISSN | 0003-4932 |
1528-1140 | |
Digital Object Identifier (DOI) | https://doi.org/10.1097/SLA.0b013e318212bff6 |
Web Address (URL) | http://www.annalsofsurgery.com |
Abstract | Objectives: To conduct a meta-analysis of randomized controlled trials evaluating the efficacy and drawbacks of limited (D1) versus extended lymphadenectomy (D2) for proven gastric adenocarcinoma. Methods: A search of Cochrane, Medline, PubMed, Embase, Science Citation Index and Current Contents electronic databases identified randomized controlled trials published in the English language between 1980 and 2008 comparing the outcomes of D1 versus D2 gastrectomy for gastric adenocarcinoma. The meta-analysis was prepared in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analyses statement. The 6 outcome variables analyzed included length of hospital stay; overall complication rate; anastomotic leak rate; reoperation rate; 30-day mortality rate and 5-year survival rate. Random effects meta-analyses were performed using Results: Six trials totaling 1876 patients (D1=946, D2=930)were analyzed. In 5 of the 6 outcomes the summary point estimates favored D1 over D2 group with a statistically significant reduction of (i) 6.37 days reduction in hospital Conclusions: On the basis of this meta-analysis we conclude that D1 gastrectomy is associated with significant fewer anastomotic leaks, postoperative complication rate, reoperation rate, decreased length of hospital stay and 30- |
Keywords | meta-analysis; D1 and D2 surgery; gastrectomy; gastric andenocarcinoma; randomised control trials |
ANZSRC Field of Research 2020 | 490102. Biological mathematics |
320209. Gastroenterology and hepatology | |
320226. Surgery | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Health, Queensland |
Department of Mathematics and Computing | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q11zx/meta-analysis-of-d1-versus-d2-gastrectomy-for-gastric-adenocarcinoma
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