Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma
Article
Article Title | Meta-analysis of histopathological outcomes of laparoscopic assisted rectal resection (LARR) vs open rectal resection (ORR) for carcinoma |
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ERA Journal ID | 15661 |
Article Category | Article |
Authors | Memon, Muhammed Ashraf (Author), Awais, Aiaman (Author), Yunus, Rossita Mohamad (Author), Memon, Breda (Author) and Khan, Shahjahan (Author) |
Journal Title | The American Journal of Surgery |
Journal Citation | 216 (5), pp. 1004-1015 |
Number of Pages | 12 |
Year | 2018 |
Place of Publication | United States |
ISSN | 0002-9610 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.amjsurg.2018.06.012 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S0002961018303234 |
Abstract | Background: We conducted a meta-analysis of the randomized evidence to determine the relative merits of histopathological outcomes of laparoscopic assisted (LARR) versus open rectal resection (ORR) forrectal cancer. Data sources: A search of PubMed and other electronic databases comparing LARR and ORR between Jan 2000 and June 2016 was performed. Histopathological variables analyzed included; location of rectaltumors; complete and incomplete TME; positive and negative circumferential resection margins(þ/-CRM); positive distal resected margins (þDRM); distance of tumor from DRM; number of lymphnodes harvested; resected specimen length; tumor size and perforated rectum. Results: Fourteen RCTs totaling 3843 patients (LARR = 2096, ORR = 1747) were analyzed. Comparable effects were noted for all these histopathological variables except for the variable perforated rectumwhich favored ORR. Conclusions: LARR compares favorably to ORR for rectal cancer treatment. However, there is significantlyhigher risk of rectal perforation during LARR compared to ORR. |
Keywords | rectal carcinoma; anterior resection; rectal resection; open surgery; laparoscopic surgery; randomized controlled trials; meat-analysis |
ANZSRC Field of Research 2020 | 490502. Biostatistics |
429999. Other health sciences not elsewhere classified | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | School of Agricultural, Computational and Environmental Sciences |
South East Queensland Surgery, Australia | |
University of Malaya, Malaysia | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q4zz8/meta-analysis-of-histopathological-outcomes-of-laparoscopic-assisted-rectal-resection-larr-vs-open-rectal-resection-orr-for-carcinoma
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