The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies from COSMIC

Article

Maasakkers, Carlijn M., Claassen, Jurgen A. H. R., Gardiner, Paul A., Olde Rikkert, Marcel G. M., Lipnicki, Darren M., Scarmeas, Nikolaos, Dardiotis, Efthimios, Yannakoulia, Mary, Anstey, Kaarin J. A., Cherbuin, Nicolas, Haan, Mary N., Kumagai, Shuzo, Narazaki, Kenji, Chen, Tao, Ng, Tze Pin, Gao, Qi, Nyunt, Ma S. Z., Crawford, John D., Kochan, Nicole A., ..., Melis, Rene J. F.. 2020. "The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies from COSMIC." Sports Medicine. 50 (2), pp. 403-413. https://doi.org/10.1007/s40279-019-01186-7
Article Title

The association of sedentary behaviour and cognitive function in people without dementia: A coordinated analysis across five cohort studies from COSMIC

ERA Journal ID9811
Article CategoryArticle
AuthorsMaasakkers, Carlijn M. (Author), Claassen, Jurgen A. H. R. (Author), Gardiner, Paul A. (Author), Olde Rikkert, Marcel G. M. (Author), Lipnicki, Darren M. (Author), Scarmeas, Nikolaos (Author), Dardiotis, Efthimios (Author), Yannakoulia, Mary (Author), Anstey, Kaarin J. A. (Author), Cherbuin, Nicolas (Author), Haan, Mary N. (Author), Kumagai, Shuzo (Author), Narazaki, Kenji (Author), Chen, Tao (Author), Ng, Tze Pin (Author), Gao, Qi (Author), Nyunt, Ma S. Z. (Author), Crawford, John D. (Author), Kochan, Nicole A. (Author), Makkar, Steve R. (Author), Sachdev, Perminder S. (Author), COSMIC Collaborators, . (Author), Thijssen, Dick H. J. (Author) and Melis, Rene J. F. (Author)
Journal TitleSports Medicine
Journal Citation50 (2), pp. 403-413
Number of Pages24
Year2020
PublisherSpringer
Place of PublicationAdis International Ltd.
ISSN0112-1642
1179-2035
Digital Object Identifier (DOI)https://doi.org/10.1007/s40279-019-01186-7
Web Address (URL)https://link.springer.com/article/10.1007%2Fs40279-019-01186-7
Abstract

Background
Besides physical activity as a target for dementia prevention, sedentary behaviour is hypothesized to be a potential target in its own right. The rising number of persons with dementia and lack of any effective treatment highlight the urgency to better understand these modifiable risk factors. Therefore, we aimed to investigate whether higher levels of sedentary behaviour are associated with reduced global cognitive functioning and slower cognitive decline in older persons without dementia.

Methods
We used five population cohorts from Greece, Australia, USA, Japan, and Singapore (HELIAD, PATH, SALSA, SGS, and SLAS2) from the Cohort Studies of Memory in an International Consortium. In a coordinated analysis, we assessed the relationship between sedentary behaviour and global cognitive function with the use of linear mixed growth model analysis (mean follow-up range of 2.0–8.1 years).

Results
Baseline datasets combined 10,450 older adults without dementia with a mean age range between cohorts of 66.7–75.1 years. After adjusting for multiple covariates, no cross-sectional association between sedentary behaviour and cognition was found in four studies. One association was detected where more sedentary behaviour was cross-sectionally linked to higher cognition levels (SLAS2, B = 0.118 (0.075; 0.160), P < 0.001). Longitudinally, there were no associations between baseline sedentary behaviour and cognitive decline (P > 0.05).

Conclusions
Overall, these results do not suggest an association between total sedentary time and lower global cognition in older persons without dementia at baseline or over time. We hypothesize that specific types of sedentary behaviour may differentially influence cognition which should be investigated further. For now, it is, however, too early to establish undifferentiated sedentary time as a potential effective target for minimizing cognitive decline in older adults without dementia.

KeywordsAged; Cognition; Cognitive Dysfunction; Cohort Studies; Dementia; Female; Humans; Male; Sedentary Behavior; Surveys and Questionnaires
ANZSRC Field of Research 2020420201. Behavioural epidemiology
420799. Sports science and exercise not elsewhere classified
520401. Cognition
Byline AffiliationsRadboud University Medical Centre, Netherlands
University of Queensland
University of New South Wales
Columbia University, United States
University of Thessaly, Greece
Harokopio University, Greece
Australian National University
University of California, United States
Kyushu University, Japan
Fukuoka Institute of Technology, Japan
National University of Singapore
Cohort Studies of Memory in an International Consortium, Australia
Liverpool John Moores University, United Kingdom
Institution of OriginUniversity of Southern Queensland
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