Sedentary behaviour and brain health in middle-aged and older adults: A systematic review

Article


Maasakkers, Carlijn M., Weijs, Ralph W. J., Dekkers, Claudia, Gardiner, Paul A., Ottens, Romy, Olde Rikkert, Marcel G. M., Melis, Rene J. F., Thijssen, Dick H. J. and Claassen, Jurgen A. H. R.. 2022. "Sedentary behaviour and brain health in middle-aged and older adults: A systematic review." Neuroscience and Biobehavioral Reviews. 140, pp. 1-10. https://doi.org/10.1016/j.neubiorev.2022.104802
Article Title

Sedentary behaviour and brain health in middle-aged and older adults: A systematic review

ERA Journal ID14481
Article CategoryArticle
AuthorsMaasakkers, Carlijn M. (Author), Weijs, Ralph W. J. (Author), Dekkers, Claudia (Author), Gardiner, Paul A. (Author), Ottens, Romy (Author), Olde Rikkert, Marcel G. M. (Author), Melis, Rene J. F. (Author), Thijssen, Dick H. J. (Author) and Claassen, Jurgen A. H. R. (Author)
Journal TitleNeuroscience and Biobehavioral Reviews
Journal Citation140, pp. 1-10
Article Number104802
Number of Pages10
Year2022
Place of PublicationUnited Kingdom
ISSN0149-7634
1873-7528
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neubiorev.2022.104802
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0149763422002913
Abstract

Sedentary behaviour may increase the risk of dementia. Studying physiological effects of sedentary behaviour on cerebral health may provide new insights into the nature of this association. Accordingly, we reviewed if and how acute and habitual sedentary behaviour relate to brain health factors in middle-aged and older adults (≥45 years). Four databases were searched. Twenty-nine studies were included, with mainly cross-sectional designs. Nine studies examined neurotrophic factors and six studied functional brain measures, with the majority of these studies finding no associations with sedentary behaviour. The results from studies on sedentary behaviour and cerebrovascular measures were inconclusive. There was a tentative association between habitual sedentary behaviour and structural white matter health. An explanatory pathway for this effect might relate to the immediate vascular effects of sitting, such as elevation of blood pressure. Nevertheless, due to the foremost cross-sectional nature of the available evidence, reverse causality could also be a possible explanation. More prospective studies are needed to understand the potential of sedentary behaviour as a target for brain health.

Keywordssedentary behaviour, neurodegeneration, brain health, sitting, dementia
ANZSRC Field of Research 2020420603. Health promotion
320210. Geriatrics and gerontology
320999. Neurosciences not elsewhere classified
Institution of OriginUniversity of Southern Queensland
Byline AffiliationsRadboud University Medical Centre, Netherlands
School of Health and Medical Sciences
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