A quest for the origin of mammal uncoupling proteins

Paper

Jastroch, Martin, Stoehr, Sigrid, Withers, Kerry and Klingenspor, Martin. 2004. "A quest for the origin of mammal uncoupling proteins." Barnes, Brian M. and Carey, Hannah V. (ed.) 12th International Hibernation Symposium. Alaska, USA 25 - 31 Jul 2004 Fairbanks, Alaska, USA.
Paper/Presentation Title

A quest for the origin of mammal uncoupling proteins

Presentation TypePaper
AuthorsJastroch, Martin (Author), Stoehr, Sigrid (Author), Withers, Kerry (Author) and Klingenspor, Martin (Author)
EditorsBarnes, Brian M. and Carey, Hannah V.
Journal or Proceedings TitleBiological Papers of the University of Alaska, v. 27
Journal Citation27, pp. 315-324
Number of Pages10
Year2004
Place of PublicationFairbanks, Alaska, USA
Conference/Event12th International Hibernation Symposium
Event Details
12th International Hibernation Symposium
Event Date
25 to end of 31 Jul 2004
Event Location
Alaska, USA
Abstract

Nonshivering thermogenesis is dependent on the presence of UCP1 in brown adipose tissue. The function of UCP2 and UCP3 is most likely related to mitochondrial superoxide metabolism and/or fatty acid oxidation. These
three members of the core UCP family are known in eutherians but had not been found in marsupials and monotremes so far. The objective of our search
is to determine the origin of UCP1 and classical nonshivering thermogenesis.
Furthermore, our approach to characterize UCP2/UCP3 in distantly related animal species will assist in the functional annotation of these proteins.
We recently reported on the molecular identifi cation, tissue-distribution, and physiological regulation of UCP2 and UCP3 mRNA in the marsupial Antechinus fl avipes (yellow-footed Antechinus). Despite separate evolution of the
marsupial lineage since 130 million years, our data suggest a conserved physiological role of these UCPs. Here, we present the immunological detection of marsupial UCP3 in skeletal muscle using antibodies raised against mouse/rat
UCP3. A comprehensive phylogenetic analysis led us to hypothesize that all uncoupling proteins were already present at the evolutionary stage of modern teleost fi shes and questions the unique presence of UCP1 in placental mammals.
However, the search for UCP1 in nonplacental mammals has been unsuccessful so far and is most likely hampered by the more rapid evolution of UCP1 as compared to other UCPs.

Keywordsnonshivering thermogenesis, yellow-footed Antechinus
ANZSRC Field of Research 2020310910. Animal physiology - systems
Public Notes

File reproduced in accordance with the copyright policy of the publisher/author.

Byline AffiliationsPhilipps-University Marburg, Germany
Department of Biological and Physical Sciences
Permalink -

https://research.usq.edu.au/item/9y5q9/a-quest-for-the-origin-of-mammal-uncoupling-proteins

Log in to edit

Download files

  • 1828
    total views
  • 480
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Bat fat: body composition analysis by total body electrical conductivity in northern long-eared bats
Tomasi, Tom, Withers, Kerry W. and Day, Katie M.. 2007. "Bat fat: body composition analysis by total body electrical conductivity in northern long-eared bats." Cook, J., Dunnum, J., Gannon, B. and Yates, T. (ed.) 87th Annual Meeting of the American Society of Mammalogists . Albuquerque, United States 06 - 10 Jun 2007 Lawrence, KS. United States.
Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats
Alam, Md. Ashraful, Kauter, Kathleen, Withers, Kerry, Sernia, Conrad and Brown, Lindsay. 2013. "Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats." Food and Function. 4 (1), pp. 83-91. https://doi.org/10.1039/c2fo30096f
Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak
Polymeropoulos, E. T., Heldmaier, G., Frappell, P. B., McAllan, B. M., Withers, K. W., Klingenspor, M., White, C. R. and Jastroch, M.. 2012. "Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak." Proceedings of the Royal Society B: Biological Sciences. 279 (1726), pp. 185-193. https://doi.org/10.1098/rspb.2011.0881
Uncoupling protein 2 and 3 in marsupials: identification, phylogeny and gene expression in response to cold and fasting in Antechinus flavipes
Jastroch, Martin, Withers, Kerry and Klingenspor, Martin. 2004. "Uncoupling protein 2 and 3 in marsupials: identification, phylogeny and gene expression in response to cold and fasting in Antechinus flavipes." Physiological Genomics. 17 (2), pp. 130-139. https://doi.org/10.1152/physiolgenomics.00165.2003
Determining the age of adult wild dogs (Canis lupus dingo, C. l. domesticus and their hybrids): I. Pulp cavity/tooth width ratios
Kershaw, K., Allen, L., Lisle, A. and Withers, K.. 2005. "Determining the age of adult wild dogs (Canis lupus dingo, C. l. domesticus and their hybrids): I. Pulp cavity/tooth width ratios." Wildlife Research. 32 (6), pp. 581-585. https://doi.org/10.1035-3712/05/060581
Measuring the density of dingo teeth with machine vision
Billingsley, John and Withers, Kerry. 2004. "Measuring the density of dingo teeth with machine vision." Sensor Review. 24 (4), pp. 361-363. https://doi.org/10.1108/02602280410558386
Behaviour of juvenile antechinus flavipes: a preliminary study
Wollenhaupt, Anja, Withers, Kerry and Billingsley, John. 2009. "Behaviour of juvenile antechinus flavipes: a preliminary study." 26th Annual Meeting of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2009). Geelong, Australia 27 - 29 Nov 2009 Perth, Australia.
Strain specific differences in parameters of energy balance are related to the onset of diet-induced obesity in young male mice
Hesse, Deike, Dunn, Mark, Billingsley, John, Withers, Kerry, Klingenspor, Martin and Rozman, Jan. 2007. "Strain specific differences in parameters of energy balance are related to the onset of diet-induced obesity in young male mice." 15th European Congress on Obesity. Budapest, Hungary 22 - 25 Apr 2007 London, United Kingdom. https://doi.org/10.1038/sj.ijo.0803597
Small mammal habitat preferences in Ravensbourne National Park, south-east Queensland
Page, Skye, Le Brocque, Andrew F. and Withers, Kerry. 2002. "Small mammal habitat preferences in Ravensbourne National Park, south-east Queensland." 2002 Conference of the Ecological Society of Australia (ESA 2002). Cairns, Australia 02 - 06 Dec 2002 Brisbane, Queensland, Australia.
Habitat preferences of small ground-dwelling mammals
Page, Skye, Le Brocque, Andrew F. and Withers, Kerry. 2003. "Habitat preferences of small ground-dwelling mammals ." Partners in Parks: 2003 Collaborative Research Forum, Queensland Parks and Wildlife Service . Brisbane, Australia 02 Oct 2003 Brisbane, Australia.
Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity
Hesse, Deike, Dunn, Mark, Heldmaier, Gerhard, Klingenspor, Martin and Rozman, Jan. 2010. "Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity." Physiology and Behavior. 99 (3), pp. 370-380. https://doi.org/10.1016/j.physbeh.2009.12.001
Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive non-shivering thermogenesis but displays increased sensitivity towards carbon-centered radicals
Jastroch, Martin, Withers, Kerry, Stoehr, Sigrid and Klingenspor, Martin. 2009. "Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive non-shivering thermogenesis but displays increased sensitivity towards carbon-centered radicals." Physiological and Biochemical Zoology. 82 (5), pp. 447-454. https://doi.org/10.1086/603631
Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, antechinus flavipes
Zhong, Wendy W. H., Withers, Kerry W. and Hoh, Joseph F. Y.. 2010. "Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, antechinus flavipes." Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology. 180 (4), pp. 531-544. https://doi.org/10.1007/s00360-009-0431-8
Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
Jastroch, M., Withers, K. W., Taudien, S., Frappell, P. B., Helwig, M., Fromme, T., Hirschberg, V., Heldmaier, G., McAllan, B. M., Firth, B. T., Burmester, T., Platzer, M. and Klingenspor, M.. 2008. "Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis." Physiological Genomics. 32 (2), pp. 161-169. https://doi.org/10.1152/physiolgenomics.00183.2007
The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus
Trzcionka, M., Withers, K. W., Klingenspor, M. and Jastroch, M.. 2008. "The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus." The Journal of Experimental Biology. 211 (12), pp. 1911-1918. https://doi.org/10.1242/jeb.016519
Heterogeneity of alpha-cardiac myosin heavy chains in a small marsupial, Antechinus flavipes, and the effect of hypothyroidism on its ventricular myosins
Hoh, Joseph F. Y., Withers, Kerry W. and Zhong, Wendy W. H.. 2008. "Heterogeneity of alpha-cardiac myosin heavy chains in a small marsupial, Antechinus flavipes, and the effect of hypothyroidism on its ventricular myosins." Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology. 178 (3), pp. 279-284. https://doi.org/10.1007/s00360-007-0220-1
Maintaining the ancient bunya tree (Araucaria bidwillii Hook.) - dispersal and mast years
Smith, I. R., Withers, Kerry and Billingsley, John. 2007. "Maintaining the ancient bunya tree (Araucaria bidwillii Hook.) - dispersal and mast years." Hill, Bill (ed.) 5th International Southern Connection Conference. Adelaide, Australia 21 - 25 Jan 2007 Adelaide, Australia.
Application of machine vision to determine the density of dingo teeth
Withers, Kerry W. and Billingsley, J.. 2004. "Application of machine vision to determine the density of dingo teeth." Buttemer, W. A., Else, P. L., Hulbert, A. J., Faulks, S. C. and Turner, N. (ed.) ANZSCPB 2004: 21st Annual Meeting of Australian and New Zealand Society for Comparative Physiology and Biochemistry. Wollongong, Australia 09 - 12 Dec 2004 Wollongong, Australia.
Pesticide effects on endocrine function in hibernating 13-lined ground squirrels
Perry, Jean, Tomasi, Thomas E. and Withers, Kerry. 2003. "Pesticide effects on endocrine function in hibernating 13-lined ground squirrels." Missouri Life Sciences Week 2003. Missouri, United States 03 - 07 Mar 2003 Missouri, MO. United States.
Pesticide effects on body temperature of torpid/hibernating rodents (Peromyscus leucopus and Spermophilus tridecemlineatus)
Tomasi, Thomas E., Elsken-Lacy, Peta, Perry, Jean A. and Withers, Kerry. 2004. "Pesticide effects on body temperature of torpid/hibernating rodents (Peromyscus leucopus and Spermophilus tridecemlineatus)." Barnes, Brian M. and Carey, Hannah V. (ed.) 12th International Hibernation Symposium. Alaska, USA 25 - 31 Jul 2004 Fairbanks,Alaska, USA.
The role of native rodents in seed dispersal and seed predation of the Bunya Pine (Araucaria bidwillii)
Smith, I. R., Withers, Kerry and Billingsley, John. 2005. "The role of native rodents in seed dispersal and seed predation of the Bunya Pine (Araucaria bidwillii)." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Use of pulp cavity/tooth width ratios to determine the age of adult wild dogs (Canis lupus dingo, C. l. domesticus and their hybrids)
Kershaw, K., Allen, L., Lisle, A. and Withers, K.. 2005. "Use of pulp cavity/tooth width ratios to determine the age of adult wild dogs (Canis lupus dingo, C. l. domesticus and their hybrids)." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Skeletal muscle mitochondria as a source of non-shivering thermogenesis in the marsupial Anthechinus flavipes
Jastroch, Martin, Withers, Kerry and Klingenspor, Martin. 2005. "Skeletal muscle mitochondria as a source of non-shivering thermogenesis in the marsupial Anthechinus flavipes." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Identifying reproductive state of the Julia Creek dunnart Sminthopsis douglasi by behavioural observations
Bjursell, A., Withers, K., Senior, G., Lundie-Jenkins, G. and Kennerley, P.. 2005. "Identifying reproductive state of the Julia Creek dunnart Sminthopsis douglasi by behavioural observations." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Application of machine vision technology to identification of oestrous in the Julia Creek dunnart (Sminthopsis douglasi)
Bjursell, A., Dunn, M., Withers, K., Senior, G., Lundie-Jenkins, G. and Billingsley, J.. 2005. "Application of machine vision technology to identification of oestrous in the Julia Creek dunnart (Sminthopsis douglasi)." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Torpor in the carnivorous marsupial Sminthopsis macroura: effects of food quality and food quantity
Withers, Kerry W., White, Debra H. and Billingsley, John. 2000. "Torpor in the carnivorous marsupial Sminthopsis macroura: effects of food quality and food quantity." Heldmaier, Gerhard, Klingenspor, Martin and Klaus, Susanne (ed.) 11th International Hibernation Symposium. Jungholz, Austria 13 - 18 Aug 2000 Berlin, Germany.