Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak

Article


Polymeropoulos, E. T., Heldmaier, G., Frappell, P. B., McAllan, B. M., Withers, K. W., Klingenspor, M., White, C. R. and Jastroch, M.. 2012. "Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak." Proceedings of the Royal Society B: Biological Sciences. 279 (1726), pp. 185-193. https://doi.org/10.1098/rspb.2011.0881
Article Title

Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak

ERA Journal ID2111
Article CategoryArticle
AuthorsPolymeropoulos, E. T. (Author), Heldmaier, G. (Author), Frappell, P. B. (Author), McAllan, B. M. (Author), Withers, K. W. (Author), Klingenspor, M. (Author), White, C. R. (Author) and Jastroch, M. (Author)
Journal TitleProceedings of the Royal Society B: Biological Sciences
Journal Citation279 (1726), pp. 185-193
Number of Pages9
Year2012
PublisherRoyal Society Publishing
Place of PublicationLondon, United Kingdom
ISSN0962-8452
1471-2954
Digital Object Identifier (DOI)https://doi.org/10.1098/rspb.2011.0881
Web Address (URL)http://rspb.royalsocietypublishing.org/content/279/1726/185.abstract
Abstract

Metabolic rates of mammals presumably increased during the evolution of endothermy, but molecular and cellular mechanisms underlying basal metabolic rate (BMR) are still not understood. It has been established that mitochondrial basal proton leak contributes significantly to BMR. Comparative studies among a diversity of eutherian mammals showed that BMR correlates with body mass and proton leak. Here, we studied BMR and mitochondrial basal proton leak in liver of various marsupial species. Surprisingly, we found that the mitochondrial proton leak was greater in marsupials than in eutherians, although marsupials have lower BMRs. To verify our finding, we kept similar-sized individuals of a marsupial opossum (Monodelphis domestica) and a eutherian rodent (Mesocricetus auratus) species under identical conditions, and directly compared BMR and basal proton leak. We confirmed an approximately 40 per cent lower mass specific BMR in the opossum although its proton leak was significantly higher (approx. 60%). We demonstrate that the increase in BMR during eutherian evolution is not based on a general increase in the mitochondrial proton leak, although there is a similar allometric relationship
of proton leak and BMR within mammalian groups. The difference in proton leak between endothermic groups may assist in elucidating distinct metabolic and habitat requirements that have evolved during mammalian divergence.

Keywordsmarsupials; eutherians; basal metabolic rate; mitochondria; basal proton leak; liver
ANZSRC Field of Research 2020310910. Animal physiology - systems
310902. Animal cell and molecular biology
310599. Genetics not elsewhere classified
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Byline AffiliationsUniversity of Tasmania
Philipps-University Marburg, Germany
University of Sydney
Centre for Systems Biology
Technical University of Munich, Germany
University of Queensland
Buck Institute for Research on Aging, United States
Institution of OriginUniversity of Southern Queensland
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