Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity

Article

Hesse, Deike, Dunn, Mark, Heldmaier, Gerhard, Klingenspor, Martin and Rozman, Jan. 2010. "Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity." Physiology and Behavior. 99 (3), pp. 370-380. https://doi.org/10.1016/j.physbeh.2009.12.001
Article Title

Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity

ERA Journal ID6563
Article CategoryArticle
AuthorsHesse, Deike (Author), Dunn, Mark (Author), Heldmaier, Gerhard (Author), Klingenspor, Martin (Author) and Rozman, Jan (Author)
Journal TitlePhysiology and Behavior
Journal Citation99 (3), pp. 370-380
Number of Pages11
Year2010
PublisherElsevier
Place of PublicationPhiladelphia, PA. United States
ISSN0031-9384
1873-507X
Digital Object Identifier (DOI)https://doi.org/10.1016/j.physbeh.2009.12.001
Abstract

We investigated inbred SWR/J and AKR/J mice, two established models for different susceptibility to dietinduced obesity (DIO), to scrutinize the contribution of physical activity and energy assimilation to the
etiology of developing obesity. Body mass gain and body composition of mice fed a high-energy (HE) or a low caloric control diet were monitored. In parallel, assimilated energy, locomotor activity and thermoregulatory behaviour were measured. Activity was continuously registered by radio telemetry and, in addition, Open Field (OF) behaviour was used as a quick screening tool for spontaneous activity before and after the feeding trial. Energy assimilation was increased in both strains on HE (AKR/J: +60.7% and SWR/J:
+42.8%) but only in AKR/J, body mass (+8.1%) and fat mass (+40.7%) were significantly elevated. As a trend, total home cage activity was increased and was more scattered in SWR/J. Interestingly, HE stimulated of activity only in SWR/J in the second trial at the end of the feeding experiment. The spatial pattern of OF activity also differed between strains with obese mice avoiding the core area. Under housing conditions, nest building behaviour was more pronounced in AKR/J. To further evaluate OF behaviour as a marker for spontaneous activity an obese mouse line was investigated. Mice lacking the leptin receptor (db/db) showed already before the onset of obesity lowest activity levels in OF.
Adjustment of energy intake, higher activity levels and energy consuming thermoregulatory behaviour are mechanisms employed by SWR/J mice to dissipate excess energy as a defence against the onset of obesity. Therefore our results deciphering mechanisms of DIO-sensitivity in mice contribute to the understanding of inter-individual differences in body weight development in an adipogenic environment.

KeywordsAKR/J; SWR/J; NEAT; inbred mouse strain; energy balance; obesity; DXA; open field; diet-induced; high caloric diet
ANZSRC Field of Research 2020420702. Exercise physiology
520402. Decision making
321004. Nutritional science
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsPhilipps-University Marburg, Germany
National Centre for Engineering in Agriculture
Technical University of Munich, Germany
Permalink -

https://research.usq.edu.au/item/9zz3q/behavioural-mechanisms-affecting-energy-regulation-in-mice-prone-or-resistant-to-diet-induced-obesity

Log in to edit
  • 1883
    total views
  • 12
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Animal management in the Australian rangelands
Finch, Neal, Murray, Peter, Dunn, Mark and Billingsley, John. 2008. "Animal management in the Australian rangelands." SPIE Newsroom. https://doi.org/10.1117/2.1200801.0960
Machine vision for animal identification
Dunn, Mark. 2007. Machine vision for animal identification. Toowoomba, Australia. University of Southern Queensland.
Review of precision livestock farming (PLF) technologies for the Australian pig industry
Banhazi, Thomas, Dunn, Mark, Cook, Peter and Durack, Matthew. 2003. Review of precision livestock farming (PLF) technologies for the Australian pig industry. Toowoomba, Australia. University of Southern Queensland.
Commercialisation of precision agriculture technologies in the macadamia industry
Rees, Steven, Dunn, Mark, Werkman, Peter and McCarthy, Cheryl. 2009. Commercialisation of precision agriculture technologies in the macadamia industry. Toowoomba, Australia. University of Southern Queensland.
Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak
Polymeropoulos, E. T., Heldmaier, G., Frappell, P. B., McAllan, B. M., Withers, K. W., Klingenspor, M., White, C. R. and Jastroch, M.. 2012. "Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak." Proceedings of the Royal Society B: Biological Sciences. 279 (1726), pp. 185-193. https://doi.org/10.1098/rspb.2011.0881
Development and evaluation of a prototype precision spot spray system using image analysis to target guinea grass in sugarcane
Rees, S. J., McCarthy, C. L., Baillie, C. P., Burgos-Artizzu, X. P. and Dunn, M. T.. 2011. "Development and evaluation of a prototype precision spot spray system using image analysis to target guinea grass in sugarcane." Australian Journal of Multi-Disciplinary Engineering. 8 (2), pp. 97-106.
Using video image analysis to count hens in cages and reduce egg breakage on collection belts
Cronin, G. M., Borg, S. S. and Dunn, M. T.. 2008. "Using video image analysis to count hens in cages and reduce egg breakage on collection belts." Animal Production Science. 48 (7), pp. 768-772. https://doi.org/10.1071/EA07404
Strain specific differences in parameters of energy balance are related to the onset of diet-induced obesity in young male mice
Hesse, Deike, Dunn, Mark, Billingsley, John, Withers, Kerry, Klingenspor, Martin and Rozman, Jan. 2007. "Strain specific differences in parameters of energy balance are related to the onset of diet-induced obesity in young male mice." 15th European Congress on Obesity. Budapest, Hungary 22 - 25 Apr 2007 London, United Kingdom. https://doi.org/10.1038/sj.ijo.0803597
Uncoupling protein 2 and 3 in marsupials: identification, phylogeny and gene expression in response to cold and fasting in Antechinus flavipes
Jastroch, Martin, Withers, Kerry and Klingenspor, Martin. 2004. "Uncoupling protein 2 and 3 in marsupials: identification, phylogeny and gene expression in response to cold and fasting in Antechinus flavipes." Physiological Genomics. 17 (2), pp. 130-139. https://doi.org/10.1152/physiolgenomics.00165.2003
Field testing of vision based macadamia yield monitoring
Dunn, Mark, Billingsley, John and Bell, David. 2005. "Field testing of vision based macadamia yield monitoring." Billingsley, John (ed.) 12th Annual Conference on Mechatronics and Machine Vision in Practice (M2VIP 2005). Manila, Philippines 29 Nov - 01 Dec 2005 Hertfordshire, England.
Development of a prototype precision spot spray system using image analysis and plant identification technology
Rees, Steven, McCarthy, Cheryl, Artizzu, X. P. B., Baillie, Craig and Dunn, Mark. 2009. "Development of a prototype precision spot spray system using image analysis and plant identification technology." Banhazi, T. M. and Saunders, C. (ed.) SEAg 2009: Agricultural Technologies In a Changing Climate. Brisbane, Australia 13 - 16 Sep 2009 Brisbane, Australia.
Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive non-shivering thermogenesis but displays increased sensitivity towards carbon-centered radicals
Jastroch, Martin, Withers, Kerry, Stoehr, Sigrid and Klingenspor, Martin. 2009. "Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive non-shivering thermogenesis but displays increased sensitivity towards carbon-centered radicals." Physiological and Biochemical Zoology. 82 (5), pp. 447-454. https://doi.org/10.1086/603631
Automated macadamia nut orchard yield monitoring
Dunn, Mark and Billingsley, John. 2005. "Automated macadamia nut orchard yield monitoring." Billingsley, John (ed.) 12th Annual Conference on Mechatronics and Machine Vision in Practice (M2VIP 2005). Manila, Philippines 29 Nov - 01 Dec 2005 Hertfordshire, England.
Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
Jastroch, M., Withers, K. W., Taudien, S., Frappell, P. B., Helwig, M., Fromme, T., Hirschberg, V., Heldmaier, G., McAllan, B. M., Firth, B. T., Burmester, T., Platzer, M. and Klingenspor, M.. 2008. "Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis." Physiological Genomics. 32 (2), pp. 161-169. https://doi.org/10.1152/physiolgenomics.00183.2007
The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus
Trzcionka, M., Withers, K. W., Klingenspor, M. and Jastroch, M.. 2008. "The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus." The Journal of Experimental Biology. 211 (12), pp. 1911-1918. https://doi.org/10.1242/jeb.016519
Robotics in agriculture and forestry
Billingsley, John, Visala, Arto and Dunn, Mark. 2008. "Robotics in agriculture and forestry." Siciliano, Bruno and Khatib, Oussama (ed.) Springer handbook of robotics. Berlin, Germany. Springer. pp. 1065-1077
The use of machine vision for assessment of fodder quality
Dunn, Mark T. and Billingsley, John. 2007. "The use of machine vision for assessment of fodder quality." Bradbeer, Robin and Ku, Kenneth (ed.) 14th Annual Conference on Mechatronics and Machine Vision In Practice (M2VIP 2007). Xiamen, China 03 - 05 Dec 2007 Hong Kong. https://doi.org/10.1109/MMVIP.2007.4430739
Vision based macadamia yield assessment
Billingsley, John, Dunn, Mark and Bell, David. 2006. "Vision based macadamia yield assessment." Sensor Review. 26 (4), pp. 312-317. https://doi.org/10.1108/02602280610692024
Using machine vision classification to control access of animals to water
Finch, N. A., Murray, P. J., Dunn, M. T. and Billingsley, J.. 2006. "Using machine vision classification to control access of animals to water." Animal Production Science. 46 (6-7), pp. 837-839. https://doi.org/10.1071/EA05325
Control of watering point access using machine vision classification of animals
Finch, Neal A., Murray, Peter J., Dunn, Mark T. and Billingsley, John. 2006. "Control of watering point access using machine vision classification of animals." Transactions of the Western Section of the Wildlife Society. 42, pp. 16-19.
Machine vision system for counting macadamia nuts
Dunn, Mark and Billingsley, John. 2003. "Machine vision system for counting macadamia nuts." Roberts, Jonathan and Wyeth, Gordon (ed.) 2003 Australasian Conference on Robotics and Automation (ACRA 2003). Brisbane, Australia 01 - 03 Dec 2003 Brisbane, Australia.
A quest for the origin of mammal uncoupling proteins
Jastroch, Martin, Stoehr, Sigrid, Withers, Kerry and Klingenspor, Martin. 2004. "A quest for the origin of mammal uncoupling proteins." Barnes, Brian M. and Carey, Hannah V. (ed.) 12th International Hibernation Symposium. Alaska, USA 25 - 31 Jul 2004 Fairbanks, Alaska, USA.
Skeletal muscle mitochondria as a source of non-shivering thermogenesis in the marsupial Anthechinus flavipes
Jastroch, Martin, Withers, Kerry and Klingenspor, Martin. 2005. "Skeletal muscle mitochondria as a source of non-shivering thermogenesis in the marsupial Anthechinus flavipes." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Application of machine vision technology to identification of oestrous in the Julia Creek dunnart (Sminthopsis douglasi)
Bjursell, A., Dunn, M., Withers, K., Senior, G., Lundie-Jenkins, G. and Billingsley, J.. 2005. "Application of machine vision technology to identification of oestrous in the Julia Creek dunnart (Sminthopsis douglasi)." Cree, Alison (ed.) 22nd Annual Conference of the Australian and New Zealand Society for Comparative Physiology and Biochemistry (ANZSCPB 2005). Dunedin, New Zealand 09 - 11 Dec 2005 New Zealand.
Machine vision classification of animals
Dunn, Mark, Billingsley, John and Finch, Neal. 2003. "Machine vision classification of animals." Billingsley, John (ed.) 10th Annual Conference on Mechatronics and Machine Vision in Practice (MViP 2003). Perth, Australia 09 - 11 Dec 2003 Research Studies Press.
Unusual vision - machine vision applications at the NCEA
Billingsley, John and Dunn, Mark. 2005. "Unusual vision - machine vision applications at the NCEA." Sensor Review. 25 (3), pp. 202-208. https://doi.org/10.1108/02602280510606480