Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis
Article
Article Title | Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis |
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ERA Journal ID | 14629 |
Article Category | Article |
Authors | Jastroch, M. (Author), Withers, K. W. (Author), Taudien, S. (Author), Frappell, P. B. (Author), Helwig, M. (Author), Fromme, T. (Author), Hirschberg, V. (Author), Heldmaier, G. (Author), McAllan, B. M. (Author), Firth, B. T. (Author), Burmester, T. (Author), Platzer, M. (Author) and Klingenspor, M. (Author) |
Journal Title | Physiological Genomics |
Journal Citation | 32 (2), pp. 161-169 |
Number of Pages | 9 |
Year | 2008 |
Place of Publication | Bethesda, MD. United States |
ISSN | 1094-8341 |
1531-2267 | |
Digital Object Identifier (DOI) | https://doi.org/10.1152/physiolgenomics.00183.2007 |
Abstract | Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least |
Keywords | marsupials; brown adipose tissue; cold acclimation |
ANZSRC Field of Research 2020 | 310404. Evolution of developmental systems |
310912. Comparative physiology | |
300902. Veterinary anatomy and physiology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Philipps-University Marburg, Germany |
Department of Biological and Physical Sciences | |
Leibniz Institute on Aging, Germany | |
La Trobe University | |
University of Sydney | |
University of Adelaide | |
University of Hamburg, Germany |
https://research.usq.edu.au/item/9zq78/marsupial-uncoupling-protein-1-sheds-light-on-the-evolution-of-mammalian-nonshivering-thermogenesis
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