Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

Article

Jastroch, M., Withers, K. W., Taudien, S., Frappell, P. B., Helwig, M., Fromme, T., Hirschberg, V., Heldmaier, G., McAllan, B. M., Firth, B. T., Burmester, T., Platzer, M. and Klingenspor, M.. 2008. "Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis." Physiological Genomics. 32 (2), pp. 161-169. https://doi.org/10.1152/physiolgenomics.00183.2007
Article Title

Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

ERA Journal ID14629
Article CategoryArticle
AuthorsJastroch, M. (Author), Withers, K. W. (Author), Taudien, S. (Author), Frappell, P. B. (Author), Helwig, M. (Author), Fromme, T. (Author), Hirschberg, V. (Author), Heldmaier, G. (Author), McAllan, B. M. (Author), Firth, B. T. (Author), Burmester, T. (Author), Platzer, M. (Author) and Klingenspor, M. (Author)
Journal TitlePhysiological Genomics
Journal Citation32 (2), pp. 161-169
Number of Pages9
Year2008
PublisherAmerican Physiological Society
Place of PublicationBethesda, MD. United States
ISSN1094-8341
1531-2267
Digital Object Identifier (DOI)https://doi.org/10.1152/physiolgenomics.00183.2007
Abstract

Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic library of Monodelphis domestica. In South American and Australian marsupials, UCP1 is exclusively expressed in distinct adipose tissue sites and appears to be recruited by cold exposure in the smallest species under investigation (Sminthopsis crassicaudata). Our data suggest that an archetypal brown adipose tissue was present at least
150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity.

Keywordsmarsupials; brown adipose tissue; cold acclimation
ANZSRC Field of Research 2020310404. Evolution of developmental systems
310912. Comparative physiology
300902. Veterinary anatomy and physiology
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Byline AffiliationsPhilipps-University Marburg, Germany
Department of Biological and Physical Sciences
Leibniz Institute on Aging, Germany
La Trobe University
University of Sydney
University of Adelaide
University of Hamburg, Germany
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