Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research
Article
Article Title | Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research |
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ERA Journal ID | 16024 |
Article Category | Article |
Authors | Wilmot, E. G. (Author), Edwardson, C. L. (Author), Biddle, S. J. H. (Author), Gorely, T. (Author), Henson, J. (Author), Khunti, K. (Author), Nimmo, M. A. (Author), Yates, T. (Author) and Davies, M. J. (Author) |
Journal Title | Diabetic Medicine |
Journal Citation | 30 (6), pp. 671-675 |
Number of Pages | 5 |
Year | 2013 |
Place of Publication | United Kingdom |
ISSN | 0742-3071 |
1464-5491 | |
Digital Object Identifier (DOI) | https://doi.org/10.1111/dme.12173 |
Web Address (URL) | http://onlinelibrary.wiley.com/doi/10.1111/dme.12173/abstract;jsessionid=86486DBDD4F33F0F6FCD87B995DD04A3.f04t04 |
Abstract | Aims: Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults. Methods: Overweight (with an additional risk factor) or obese adults (18-40 years) were recruited for the Sedentary Time And Diabetes (STAND) randomized controlled trial. Measures included an oral glucose tolerance test, HbA1c, biochemical and anthropometric data. Results: One hundred and ninety-three individuals (68% female; median age 33.8 years; median BMI 33.9 kg/m2) were recruited. Forty-three per cent had a first-degree family history of Type 2 diabetes. Previously undiagnosed Type 2 diabetes was present in 4.7% (n = 9). Of participants, 18.1% (n = 35) had impaired glucose metabolism: 4.7% (n = 9) HbA1c ≥ 48 mmol/mol (6.5%); 9.3% (n = 18) HbA1c 42-46 mmol/mol (6.0-6.4%); 3.1% (n = 6) Type 2 diabetes on oral glucose tolerance test; 6.2% (n = 12) isolated impaired glucose tolerance; 2.1% (n = 4) isolated impaired fasting glucose; 1% (n = 2) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (n = 113) had dyslipidaemia, 28.0% (n = 54) had hypertension, 31.1% (n = 60) were vitamin D deficient and 7.3% (n = 14) had abnormal liver function. Conclusions: This study identified a high prevalence of Type 2 diabetes and impaired glucose regulation in overweight and obese younger adults. These findings require confirmation in a larger, representative, population. © 2013 Diabetes UK. |
Keywords | CLINICAL CHEMISTRY; PHYSIOLOGY; Endocrine Pancreas; Diabetes, insulin, and glucose tolerance; ENDOCRINOLOGY AND METABOLISM; CARBOHYDRATE METABOLISM; Glucose Transport and Metabolism; Public Health, Social Medicine and Epidemiology; HEALTH CARE; Public Health, Social Medicine and Epidemiology; EPIDEMIOLOGY, SCREENING AND PREVENTION; Public Health, Social Medicine and Epidemiology; POPULATIONS AT RISK; Endocrinology; HORMONE-RELATED METABOLISM; Diabetes mellitus; Internal Medicine; ENDOCRINE SYSTEM; Diabetes; Internal Medicine; EPIDEMIOLOGY AND PREVENTION; |
ANZSRC Field of Research 2020 | 420702. Exercise physiology |
321004. Nutritional science | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Leicester, United Kingdom |
Loughborough University, United Kingdom | |
University of Stirling, United Kingdom | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q41z9/prevalence-of-diabetes-and-impaired-glucose-metabolism-in-younger-at-risk-uk-adults-insights-from-the-stand-programme-of-research
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