Preparation and characterization of carbon nanotube-grafted-chitosan - Natural hydroxyapatite composite for bone tissue engineering
Article
Venkatesan, Jayachandran, Qian, Zhong-Ji, Ryu, BoMi, Kumar, Nanjundan Ashok and Kim, Se-Kwon. 2011. "Preparation and characterization of carbon nanotube-grafted-chitosan - Natural hydroxyapatite composite for bone tissue engineering." Carbohydrate Polymers. 83 (2), pp. 569-577. https://doi.org/10.1016/j.carbpol.2010.08.019
Article Title | Preparation and characterization of carbon nanotube-grafted-chitosan - Natural hydroxyapatite composite for bone tissue engineering |
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ERA Journal ID | 1568 |
Article Category | Article |
Authors | Venkatesan, Jayachandran, Qian, Zhong-Ji, Ryu, BoMi, Kumar, Nanjundan Ashok and Kim, Se-Kwon |
Journal Title | Carbohydrate Polymers |
Journal Citation | 83 (2), pp. 569-577 |
Number of Pages | 9 |
Year | 2011 |
Publisher | Elsevier |
Place of Publication | United Kingdom |
ISSN | 0144-8617 |
1879-1344 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.carbpol.2010.08.019 |
Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/S0144861710006399 |
Abstract | Porous, biodegradable and biocompatible chitosan, chitosan with natural hydroxyapatite derived from Thunnus Obesus bone (chitosan/HAp) and chitosan grafted with functionalized multiwalled carbon nanotube in addition to HAp (f-MWCNT-g-chitosan/HAp) scaffolds were prepared for the first time via freeze-drying method and physiochemically characterized as bone graft substitutes. The cross-linkages in the novel f-MWCNT-g-chitosan/HAp scaffold were observed by FT-IR spectroscopy. The water uptake, retention ability and degradation of composite scaffolds decreased whereas thermal stability increased with an addition of HAp and f-MWCNT. Uniform dispersion of HAp and f-MWCNT in chitosan matrix with interconnected porosity of 70–200 μm (chitosan/HAp) and 46–200 μm (f-MWCNT-g-chitosan/HAp) was observed by X-ray diffraction, scanning electron microscopy and optical microscopy. Cell proliferation in composite scaffolds was twice than in pure chitosan when checked in vitro using MG-63 cell line. These observations suggest that the novel chitosan/HAp and f-MWCNT-g-chitosan/HAp composite scaffolds are promising biomaterials for bone tissue engineering. |
Keywords | Bone tissue engineering; Hydroxyapatite; Chitosan; Functionalized multiwalled carbon; nanotube; Scaffolds |
ANZSRC Field of Research 2020 | 4003. Biomedical engineering |
4018. Nanotechnology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Pukyong National University, Korea |
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