Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease
Article
Article Title | Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease |
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ERA Journal ID | 2230 |
Article Category | Article |
Authors | Gasparotto, Juciano (Author), Senger, Mario Roberto (Author), de Sa Moreira, Emilio Telles (Author), Brum, Pedro Ozorio (Author), Kessler, Flavio Gabriel Carazza (Author), Peixoto, Daniel Oppermann (Author), Panzenhagen, Alana Castro (Author), Ong, Lin Kooi (Author), Soares, Marlene Campos (Author), Reis, Patricia Alves (Author), Schirato, Giuliana Viegas (Author), Valente, Walter Cesar Goes (Author), Montoya, Bogar Omar Araujo (Author), Silva, Floriano P. (Author), Moreira, Jose Claudio Fonseca (Author), Dal-Pizzol, Felipe (Author), Castro-Faria-Neto, Hugo C. (Author) and Gelain, Daniel Pens (Author) |
Journal Title | Journal of Biological Chemistry |
Journal Citation | 297 (2), pp. 1-17 |
Article Number | 100979 |
Number of Pages | 17 |
Year | 2021 |
Place of Publication | United States |
ISSN | 0021-9258 |
1083-351X | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jbc.2021.100979 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S002192582100781X |
Abstract | Schistosomiasis, a neglected tropical disease caused by trematodes of the Schistosoma genus, affects over 250 million people around the world. This disease has been associated with learning and memory deficits in children, whereas reduced attention levels, impaired work capacity, and cognitive deficits have been observed in adults. Strongly correlated with poverty and lack of basic sanitary conditions, this chronic endemic infection is common in Africa, South America, and parts of Asia and contributes to inhibition of social development and low quality of life in affected areas. Nonetheless, studies on the mechanisms involved in the neurological impairment caused by schistosomiasis are scarce. Here, we used a murine model of infection with Schistosoma mansoni in which parasites do not invade the central nervous system to evaluate the consequences of systemic infection on neurologic function. We observed that systemic infection with S. mansoni led to astrocyte and microglia activation, expression of oxidative stress-induced transcription factor Nrf2, oxidative damage, Tau phosphorylation, and amyloid-β peptide accumulation in the prefrontal cortex of infected animals. We also found impairment in spatial learning and memory as evaluated by the Morris water maze task. Administration of anthelmintic (praziquantel) and antioxidant (N-acetylcysteine plus deferoxamine) treatments was effective in inhibiting most of these phenotypes, and the combination of both treatments had a synergistic effect to prevent such changes. These data demonstrate new perspectives toward the understanding of the pathology and possible therapeutic approaches to counteract long-term effects of systemic schistosomiasis on brain function. |
Keywords | Amyloid-beta peptides; Central nervous systems; Learning and memory; Neglected tropical disease; Neurologic function; Schistosoma mansoni; Social development; Synergistic effect |
ANZSRC Field of Research 2020 | 320499. Immunology not elsewhere classified |
321405. Pharmaceutical sciences | |
320902. Cellular nervous system | |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | Federal University of Rio Grande do Sul, Brazil |
Oswaldo Cruz Foundation (Fiocruz), Brazil | |
Monash University | |
University of the Extreme South of Santa Catarina, Brazil |
https://research.usq.edu.au/item/q748x/neurological-impairment-caused-by-schistosoma-mansoni-systemic-infection-exhibits-early-features-of-idiopathic-neurodegenerative-disease
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