More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke
Article
Article Title | More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke |
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ERA Journal ID | 16327 |
Article Category | Article |
Authors | Sanchez-Bezanilla, Sonia (Author), Hood, Rebecca J. (Author), Collins-Praino, Lyndsey E. (Author), Turner, Renee J. (Author), Walker, Frederick R. (Author), Nilsson, Michael (Author) and Ong, Lin Kooi (Author) |
Journal Title | Journal of Cerebral Blood Flow and Metabolism |
Journal Citation | 41 (9), pp. 2439-2455 |
Number of Pages | 17 |
Year | 2021 |
Place of Publication | United Kingdom |
ISSN | 0271-678X |
1559-7016 | |
Digital Object Identifier (DOI) | https://doi.org/10.1177/0271678X211005877 |
Web Address (URL) | https://journals.sagepub.com/doi/10.1177/0271678X211005877 |
Abstract | There is emerging evidence suggesting that a cortical stroke can cause delayed and remote hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to investigate motor and cognitive outcomes after experimental stroke, and their association with secondary neurodegenerative processes. Specifically, we used a photothrombotic stroke model targeting the motor and somatosensory cortices of mice. Motor function was assessed using the cylinder and grid walk tasks. Changes in cognition were assessed using a mouse touchscreen platform. Neuronal loss, gliosis and amyloid-β accumulation were investigated in the peri-infarct and ipsilateral hippocampal regions at 7, 28 and 84 days post-stroke. Our findings showed persistent impairment in cognitive function post-stroke, whilst there was a modest spontaneous motor recovery over the investigated period of 84 days. In the peri-infarct region, we detected a reduction in neuronal loss and decreased neuroinflammation over time post-stroke, which potentially explains the spontaneous motor recovery. Conversely, we observed persistent neuronal loss together with concomitant increased neuroinflammation and amyloid-β accumulation in the hippocampus, which likely accounts for the persistent cognitive dysfunction. Our findings indicate that cortical stroke induces secondary neurodegenerative processes in the hippocampus, a region remote from the primary infarct, potentially contributing to the progression of post-stroke cognitive impairment. |
Keywords | amyloid-β; Cognitive impairment; neuroinflammation; secondary neurodegeneration; stroke |
ANZSRC Field of Research 2020 | 320905. Neurology and neuromuscular diseases |
320902. Cellular nervous system | |
520401. Cognition | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Newcastle |
University of Adelaide | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q748v/more-than-motor-impairment-a-spatiotemporal-analysis-of-cognitive-impairment-and-associated-neuropathological-changes-following-cortical-photothrombotic-stroke
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