Brain repair mechanisms after cell therapy for stroke

Article

Rust, Ruslan, Nih, Lina R., Liberale, Luca, Yin, Hao, El Amki, Mohamad, Ong, Lin Kooi and Zlokovic, Berislav V.. 2024. "Brain repair mechanisms after cell therapy for stroke." Brain. https://doi.org/10.1093/brain/awae204
Article Title

Brain repair mechanisms after cell therapy for stroke

Article CategoryArticle
AuthorsRust, Ruslan, Nih, Lina R., Liberale, Luca, Yin, Hao, El Amki, Mohamad, Ong, Lin Kooi and Zlokovic, Berislav V.
Journal TitleBrain
Number of Pages20
Year2024
PublisherOxford University Press
Place of PublicationUnited Kingdom
ISSN0006-8950
1460-2156
Digital Object Identifier (DOI)https://doi.org/10.1093/brain/awae204
Web Address (URL)https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae204/7698450
AbstractCell-based therapies hold great promise for brain repair after stroke. While accumulating evidence confirms the preclinical and clinical benefits of cell therapies, the underlying mechanisms by which they promote brain repair remain unclear. Here, we briefly review endogenous mechanisms of brain repair after ischaemic stroke and then focus on how different stem and progenitor cell sources can promote brain repair.Specifically, we examine how transplanted cell grafts contribute to improved functional recovery either through direct cell replacement or by stimulating endogenous repair pathways. Additionally, we discuss recently implemented preclinical refinement methods, such as preconditioning, microcarriers, genetic safety switches and universal (immune evasive) cell transplants, as well as the therapeutic potential of these pharmacologic and genetic manipulations to further enhance the efficacy and safety of cell therapies.By gaining a deeper understanding of post-ischaemic repair mechanisms, prospective clinical trials may be further refined to advance post-stroke cell therapy to the clinic. Rust et al. review mechanisms of brain repair after ischaemic stroke, focusing on the potential of stem cells to enhance recovery. They discuss the challenges faced by cell therapies in recent clinical trials and consider how advances in preclinical research might pave the way for next-generation cell therapies.
Keywordsstem cells; ischaemia; brain injury; iPSC; regeneration; therapy
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020320903. Central nervous system
Byline AffiliationsUniversity of Southern California, United States
University of Zurich, Switzerland
University of Genoa, Italy
IRCCS San Martino Polyclinic Hospital, Italy
Western University London, Canada
School of Health and Medical Sciences
Centre for Health Research
Permalink -

https://research.usq.edu.au/item/z9946/brain-repair-mechanisms-after-cell-therapy-for-stroke

Log in to edit

Download files

Published Version
awae204.pdf
License: CC BY-NC 4.0
File access level: Anyone

  • 9
    total views
  • 3
    total downloads
  • 3
    views this month
  • 2
    downloads this month

Export as

Related outputs

The relationship between hair cortisol concentration and autism diagnosis
Lin, Ping-I, John, James Rufus, Masi, Anne, Ong, Lin Kooi, Mathew, Nisha E., Moni, Mohammed Ali, Eapen, Valsamma and Walker, Adam K.. 2024. "The relationship between hair cortisol concentration and autism diagnosis." Journal of Psychiatric Research. 176, pp. 68-76. https://doi.org/10.1016/j.jpsychires.2024.05.052
Development of audio-guided deep breathing and auditory Go/No-Go task on evaluating its impact on the wellness of young adults: a pilot study
Kwa, Eng Keat, Cheong, Soon Keng, Ong, Lin Kooi and Lee, Poh Foong. 2024. "Development of audio-guided deep breathing and auditory Go/No-Go task on evaluating its impact on the wellness of young adults: a pilot study." Biomedizinische Technik. 69 (2), pp. 141-150. https://doi.org/10.1515/bmt-2023-0410
Editorial: Stress, mood, and fatigue: Tackling “invisible” obstacles in stroke rehabilitation and recovery
Gyawali, Prajwal, Wong, Dana, Hordacre, Brenton, Ong, Lin Kooi and English, Coralie. 2023. "Editorial: Stress, mood, and fatigue: Tackling “invisible” obstacles in stroke rehabilitation and recovery ." Frontiers in Neurology. 13. https://doi.org/10.3389/fneur.2022.1121667
Meta-analysis of studies on protection provided by different prophylactic agents, their routes of administration and incubation times against nodavirus infection in Macrobrachium rosenbergii
Chen, Ken Fong, Maran, Sathiya, Tan, Wen Siang, Ong, Lin Kooi, Abidin, Syafiq Asnawi Zainal, Othman, Iekhsan, Tey, Beng Ti and Lee, Ronald Fook Seng. 2023. "Meta-analysis of studies on protection provided by different prophylactic agents, their routes of administration and incubation times against nodavirus infection in Macrobrachium rosenbergii." Aquaculture. 565. https://doi.org/10.1016/j.aquaculture.2022.739125
Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke
Ong, Lin Kooi. 2022. "Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke." International Journal of Molecular Sciences. 23 (24), pp. 1-3. https://doi.org/10.3390/ijms232416024
Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice
Sanchez-Bezanilla, Sonia, Beard, Daniel J., Hood, Rebecca J., Aberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jorgen and Ong, Lin Kooi. 2022. "Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice." Neural Plasticity. 2022, pp. 1-13. https://doi.org/10.1155/2022/9983042
Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study
Gyawali, Prajwal, Hinwood, Madeleine, Chow, Wei Zhen, Kluge, Murielle, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study." Brain, Behavior, & Immunity - Health. 9, pp. 1-6. https://doi.org/10.1016/j.bbih.2020.100157
Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms
Zhao, Zidan, Hood, Rebecca J., Ong, Lin Kooi, Pietrogrande, Giovanni, Sanchez Bezanilla, Sonia, Warren, Kirby E., Ilicic, Marina, Kluge, Murielle G., TeBay, Clifford, Ottersen, Ole P., Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2021. "Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms." Frontiers in Neurology. 12, pp. 1-14. https://doi.org/10.3389/fneur.2021.585189
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke
Sanchez-Bezanilla, Sonia, Hood, Rebecca J., Collins-Praino, Lyndsey E., Turner, Renee J., Walker, Frederick R., Nilsson, Michael and Ong, Lin Kooi. 2021. "More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke." Journal of Cerebral Blood Flow and Metabolism. 41 (9), pp. 2439-2455. https://doi.org/10.1177/0271678X211005877
Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra
Ong, Lin Kooi, Briggs, Gabrielle D., Guan, Liying, Dunkley, Peter R. and Dickson, Phillip W.. 2021. "Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra." Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry. 146, pp. 1-10. https://doi.org/10.1016/j.neuint.2021.105022
Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease
Gasparotto, Juciano, Senger, Mario Roberto, de Sa Moreira, Emilio Telles, Brum, Pedro Ozorio, Kessler, Flavio Gabriel Carazza, Peixoto, Daniel Oppermann, Panzenhagen, Alana Castro, Ong, Lin Kooi, Soares, Marlene Campos, Reis, Patricia Alves, Schirato, Giuliana Viegas, Valente, Walter Cesar Goes, Montoya, Bogar Omar Araujo, Silva, Floriano P., Moreira, Jose Claudio Fonseca, Dal-Pizzol, Felipe, Castro-Faria-Neto, Hugo C. and Gelain, Daniel Pens. 2021. "Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease." Journal of Biological Chemistry. 297 (2), pp. 1-17. https://doi.org/10.1016/j.jbc.2021.100979
The Macrobrachiumrosenbergii nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention
Chen, Ken Fong, Tan, Wen Siang, Ong, Lin Kooi, Abidin, Syafiq Asnawi Zainal, Othman, Iekhsan, Tey, Beng Ti and Lee, Ronald Fook Seng. 2021. "The Macrobrachiumrosenbergii nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention." Reviews in Aquaculture. 13 (4), pp. 2117-2141. https://doi.org/10.1111/raq.12562
Corticosterone Administration Alters White Matter Tract Structure and Reduces Gliosis in the Sub-Acute Phase of Experimental Stroke
Zalewska, Katarzyna, Hood, Rebecca J., Pietrogrande, Giovanni, Sanchez-Bezanilla, Sonia, Ong, Lin Kooi, Johnson, Sarah J., Young, Kaylene M., Nilsson, Michael and Walker, Frederick R.. 2021. "Corticosterone Administration Alters White Matter Tract Structure and Reduces Gliosis in the Sub-Acute Phase of Experimental Stroke." International Journal of Molecular Sciences. 22 (13), pp. 1-15. https://doi.org/10.3390/ijms22136693
Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?
Stuckey, Shannon M., Ong, Lin Kooi, Collins-Praino, Lyndsey E. and Turner, Renee J.. 2021. "Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?" International Journal of Molecular Sciences. 22 (23), pp. 1-45. https://doi.org/10.3390/ijms222313101
Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease
Lee, Natasha Ting, Ong, Lin Kooi, Gyawali, Prajwal, Nassir, Che Mohd Nasril Che Mohd, Mustapha, Muzaimi, Nandurkar, Harshal H. and Sashindranath, Maithili. 2021. "Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease." Biomolecules. 11 (7). https://doi.org/10.3390/biom11070994
Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease
Nassir, Che Mohd Nasril Che Mohd, Ghazali, Mazira Mohamad, Hashim, Sabarisah, Idris, Nur Suhaila, Yuen, Lee Si, Hui, Wong Jia, Norman, Haziq Hazman, Gau, Chuang Huei, Jayabalan, Nanthini, Na, Yuri, Feng, Linqing, Ong, Lin Kooi, Hamid, Hafizah Abdul, Ahamed, Haja Nazeer and Mustapha, Muzaimi. 2021. "Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease." Frontiers in Cardiovascular Medicine. 8, pp. 1-32. https://doi.org/10.3389/fcvm.2021.632131
Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task
Chow, Wei Zhen, Ong, Lin Kooi, Kluge, Murielle G., Gyawali, Prajwal, Walker, Frederick R. and Nilsson, Michael. 2020. "Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task." Scientific Reports. 10, pp. 1-8. https://doi.org/10.1038/s41598-020-76560-x
Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study
Gyawali, Prajwal, Chow, Wei Zhen, Hinwood, Madeleine, Kluge, Murielle, English, Coralie, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study." Frontiers in Neurology. 11, pp. 1-12. https://doi.org/10.3389/fneur.2020.00230
Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke
Sanchez-Bezanilla, Sonia, Aberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jorgen and Ong, Lin Kooi. 2020. "Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke." International Journal of Molecular Sciences. 21 (12), pp. 1-16. https://doi.org/10.3390/ijms21124563
Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area
Sanchez-Bezanilla, Sonia, Aberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jörgen and Ong, Lin Kooi. 2020. "Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area." International Journal of Molecular Sciences. 21 (2), pp. 1-20. https://doi.org/10.3390/ijms21020606
Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke
Kluge, Murielle G., Abdolhoseini, Mahmoud, Zalewska, Katarzyna, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2019. "Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke." Journal of Cerebral Blood Flow and Metabolism. 39 (12), pp. 2456-2470. https://doi.org/10.1177/0271678X18797346
Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins
Sanchez-Bezanilla, Sonia, TeBay, Clifford, Nilsson, Michael, Walker, Frederick R. and Ong, Lin Kooi. 2019. "Visual discrimination impairment after experimental stroke is associated with disturbances in the polarization of the astrocytic aquaporin-4 and increased accumulation of neurotoxic proteins." Experimental Neurology. 318, pp. 232-243. https://doi.org/10.1016/j.expneurol.2019.05.001
Can We Use 2,3,5-Triphenyltetrazolium Chloride-Stained Brain Slices for Other Purposes? The Application of Western Blotting
Sanchez-Bezanilla, Sonia, Nilsson, Michael, Walker, Frederick R. and Ong, Lin Kooi. 2019. "Can We Use 2,3,5-Triphenyltetrazolium Chloride-Stained Brain Slices for Other Purposes? The Application of Western Blotting." Frontiers in Molecular Neuroscience. 12, pp. 1-12. https://doi.org/10.3389/fnmol.2019.00181
Low oxygen post conditioning prevents thalamic secondary neuronal loss caused by excitotoxicity after cortical stroke
Pietrogrande, Giovanni, Zalewska, Katarzyna, Zhao, Zidan, Abdolhoseini, Mahmoud, Chow, Wei Zhen, Sanchez-Bezanilla, Sonia, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2019. "Low oxygen post conditioning prevents thalamic secondary neuronal loss caused by excitotoxicity after cortical stroke." Scientific Reports. 9, pp. 1-9. https://doi.org/10.1038/s41598-019-39493-8
Frequent, short bouts of light-intensity exercises while standing decreases systolic blood pressure: Breaking Up Sitting Time after Stroke (BUST-Stroke) trial
English, Coralie, Janssen, Heidi, Crowfoot, Gary, Bourne, Josephine, Callister, Robin, Dunn, Ashlee, Oldmeadow, Christopher, Ong, Lin K., Palazzi, Kerrin, Patterson, Amanda, Spratt, Neil J., Walker, F. R., Dunstan, David W. and Bernhardt, Julie. 2018. "Frequent, short bouts of light-intensity exercises while standing decreases systolic blood pressure: Breaking Up Sitting Time after Stroke (BUST-Stroke) trial." International Journal of Stroke. 13 (9), pp. 932-940. https://doi.org/10.1177/1747493018798535
Breaking up sitting time after stroke (BUST-stroke)
English, Coralie, Janssen, Heidi, Crowfoot, Gary, Callister, Robin, Dunn, Ashlee, Mackie, Paul, Oldmeadow, Christopher, Ong, Lin K., Palazzi, Kerrin, Patterson, Amanda J., Spratt, Neil J., Walker, F. Rohan, Bernhardt, Julie and Dunstan, David W.. 2018. "Breaking up sitting time after stroke (BUST-stroke)." International Journal of Stroke. 13 (9), pp. 921-931. https://doi.org/10.1177/1747493018801222
Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke
Kluge, Murielle G., Jones, Kimberley, Ong, Lin Kooi, Gowing, Emma K., Nilsson, Michael, Clarkson, Andrew N. and Walker, Frederick R.. 2018. "Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke." Neuroscience. 393, pp. 185-195. https://doi.org/10.1016/j.neuroscience.2018.07.034
Growth Hormone Deficiency Is Frequent After Recent Stroke
Lillicrap, Thomas, Garcia-Esperon, Carlos, Walker, Frederick Rohan, Ong, Lin Kooi, Nilsson, Michael, Spratt, Neil, Levi, Christopher R., Parsons, Mark, Isgaard, Jorgen and Bivard, Andrew. 2018. "Growth Hormone Deficiency Is Frequent After Recent Stroke." Frontiers in Neurology. 9, pp. 1-4. https://doi.org/10.3389/fneur.2018.00713
Neonatal overfeeding increases capacity for catecholamine biosynthesis from the adrenal gland acutely and long-term in the male rat
Sominsky, Luba, Ong, Lin Kooi, Ziko, Ilvana, Dickson, Phillip W. and Spencer, Sarah J.. 2018. "Neonatal overfeeding increases capacity for catecholamine biosynthesis from the adrenal gland acutely and long-term in the male rat." Molecular and Cellular Endocrinology. 470, pp. 295-303. https://doi.org/10.1016/j.mce.2017.11.014
Growth Hormone Improves Cognitive Function After Experimental Stroke
Ong, Lin Kooi, Chow, Wei Zhen, TeBay, Clifford, Kluge, Murielle, Pietrogrande, Giovanni, Zalewska, Katarzyna, Crock, Patricia, Åberg, N. David, Bivard, Andrew, Johnson, Sarah J., Walker, Frederick R., Nilsson, Michael and Isgaard, Jorgen. 2018. "Growth Hormone Improves Cognitive Function After Experimental Stroke." Stroke. 49 (5), pp. 1257 - 1266. https://doi.org/10.1161/STROKEAHA.117.020557
Sustained administration of corticosterone at stress-like levels after stroke suppressed glial reactivity at sites of thalamic secondary neurodegeneration
Zalewska, Katarzyna, Pietrogrande, Giovanni, Ong, Lin Kooi, Abdolhoseini, Mahmoud, Kluge, Murielle, Johnson, Sarah J., Walker, Frederick R. and Nilsson, Michael. 2018. "Sustained administration of corticosterone at stress-like levels after stroke suppressed glial reactivity at sites of thalamic secondary neurodegeneration." Brain, Behavior, and Immunity. 69, pp. 210-222. https://doi.org/10.1016/j.bbi.2017.11.014
Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
Zhao, Zidan, Ong, Lin Kooi, Johnson, Sarah, Nilsson, Michael and Walker, Frederick R.. 2017. "Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke." Journal of Cerebral Blood Flow and Metabolism. 37 (12), pp. 3709-3724. https://doi.org/10.1177/0271678X17696100
Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration
Kluge, Murielle G., Kracht, Laura, Mahmoud Abdolhoseini, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration." Glia. 65 (12), pp. 1885-1899. https://doi.org/10.1002/glia.23201
Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla
Ong, Lin Kooi, Page, Scott, Briggs, Gabrielle D., Guan, Liying, Dun, Matthew D., Verrills, Nicole M., Dunkley, Peter R. and Dickson, Phillip W.. 2017. "Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla." Journal of Cellular Biochemistry. 118 (8), pp. 2096-2107. https://doi.org/10.1002/jcb.25839
Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke
Zalewska, Katarzyna, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke." Neuroscience. 352, pp. 30-38. https://doi.org/10.1016/j.neuroscience.2017.03.005
Oral corticosterone administration alone is sufficient to simulate the actions of chronic stress on glial cells but not on vasculature
Zalewska, K., Ong, L. K., Pietrogrande, G., Johnson, S. J., Nilsson, M. and Walker, F. R.. 2017. "Oral corticosterone administration alone is sufficient to simulate the actions of chronic stress on glial cells but not on vasculature." 13th European Meeting on Glial Cells in Health and Disease (2017). Scotland 08 - 11 Jul 2017 United States.
Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice
Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, Walker, Frederick R. and Nilsson, Michael. 2017. "Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice." Journal of Cerebral Blood Flow and Metabolism. 37 (4), pp. 1338-1348. https://doi.org/10.1177/0271678X16654920
Authors’ response re: ‘‘Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?” by Ong et al. Brain Behavior and Immunity, 2016
Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick R.. 2017. "Authors’ response re: ‘‘Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?” by Ong et al. Brain Behavior and Immunity, 2016." Brain, Behavior, and Immunity. 60, pp. 384-384. https://doi.org/10.1016/j.bbi.2016.11.029
Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?
Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, TeBay, Clifford, Zalewska, Katarzyna, Dickson, Phillip W., Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?" Brain, Behavior, and Immunity. 60, pp. 117-125. https://doi.org/10.1016/j.bbi.2016.10.001
Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons
Ong, Lin Kooi, Fuller, Erin A., Sominsky, Luba, Hodgson, Deborah M., Dunkley, Peter R. and Dickson, Phillip W.. 2017. "Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons." Scientific Reports. 7, pp. 1-6. https://doi.org/10.1038/srep40475
Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum
James, Morgan H., Quinn, Rikki K., Ong, Lin Kooi, Levi, Emily M., Smith, Doug W., Dickson, Phillip W. and Dayas, Christopher V.. 2016. "Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum." European Journal of Pharmacology. 784, pp. 147-154. https://doi.org/10.1016/j.ejphar.2016.05.013
Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese
Peres, Tanara V., Ong, Lin K., Costa, Ana Paula, Eyng, Helena, Venske, De´bora K. R., Colle, Dirleise, Gonçalves, Filipe M., Lopes, Mark W., Farina, Marcelo, Aschner, Michael, Dickson, Phillip W., Dunkley, Peter R. and Leal, Rodrigo B.. 2016. "Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese." Metallomics: integrated biometal science. 8 (6), pp. 597-604. https://doi.org/10.1039/c5mt00265f
Inflammation and dopamine synthesis in neurodegeneration
Ong, Lin Kooi, Briggs, G., Guan, L., Dunkley, P. and Dickson, P.. 2015. "Inflammation and dopamine synthesis in neurodegeneration." 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society (2015). Cairns, Australia 23 - 27 Aug 2015 United Kingdom.
The role of inflammation and dopamine synthesis in Parkinson's disease
Ong, L. K., Briggs, G. D., Dunkley, P. R. and Dickson, P. W.. 2014. "The role of inflammation and dopamine synthesis in Parkinson's disease." 12th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry (2014). Taiwan 23 - 26 Aug 2014 United Kingdom.
mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIa Levels
James, Morgan H., Quinn, Rikki K., Ong, Lin Kooi, Levi, Emily M., Charnley, Janine L., Smith, Doug W., Dickson, Phillip W. and Dayas, Christopher V.. 2014. "mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIa Levels." Neuropsychopharmacology. 39 (7), pp. 1694-1702. https://doi.org/10.1038/npp.2014.16
Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla
Ong, Lin Kooi, Guan, Liying, Damanhuri, Hanafi, Goodchild, Ann K., Bobrovskaya, Larisa, Dickson, Phillip W. and Dunkley, Peter R.. 2014. "Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla." Journal of Neurochemistry. 128 (4), pp. 547-560. https://doi.org/10.1111/jnc.12482
Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner
Bobrovskaya, Larisa, Maniam, Jayanthi, Ong, Lin Kooi, Dunkley, Peter R. and Morris, Margaret J.. 2013. "Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner." Neurochemical Research. 38 (4), pp. 826-833. https://doi.org/10.1007/s11064-013-0985-4
Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety
Sominsky, Luba, Fuller, Erin A., Bondarenko, Evgeny, Ong, Lin Kooi, Averell, Lee, Nalivaiko, Eugene, Dunkley, Peter R., Dickson, Phillip W. and Hodgson, Deborah M.. 2013. "Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety." PLoS One. 8 (3), pp. 1-13. https://doi.org/10.1371/journal.pone.0057700
Tyrosine Hydroxylase Phosphorylation in Catecholaminergic Brain Regions: A Marker of Activation following Acute Hypotension and Glucoprivation
Damanhuri, Hanafi A., Burke, Peter G. R., Ong, Lin K., Bobrovskaya, Larisa, Dickson, Phillip W., Dunkley, Peter R. and Goodchild, Ann K.. 2012. "Tyrosine Hydroxylase Phosphorylation in Catecholaminergic Brain Regions: A Marker of Activation following Acute Hypotension and Glucoprivation." PLoS One. 7 (11), pp. 1-19. https://doi.org/10.1371/journal.pone.0050535
The Sustained Phase of Tyrosine Hydroxylase Activation In vivo
Ong, Lin Kooi, Sominsky, Luba, Dickson, Phillip W., Hodgson, Deborah M. and Dunkley, Peter R.. 2012. "The Sustained Phase of Tyrosine Hydroxylase Activation In vivo." Neurochemical Research. 37 (9), pp. 1938-1943. https://doi.org/10.1007/s11064-012-0812-3
Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic
Sominsky, L., Walker, A. K., Ong, L. K., Tynan, R. J., Walker, F. R. and Hodgson, D. M.. 2012. "Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic." Behavioural Brain Research. 226 (1), pp. 351-356. https://doi.org/10.1016/j.bbr.2011.08.038
The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland
Ong, L. K., Guan, L., Stutz, B., Dickson, P. W., Dunkley, P. R. and Bobrovskaya, L.. 2011. "The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland." Neuroscience. 192, pp. 20-27. https://doi.org/10.1016/j.neuroscience.2011.06.087
Epigenetic Inheritance of Anxiety-Like Behaviour in Rats - Role of Early Life Exposure to a Bacterial Mimetic
Sominsky, L., Walker, A. K., Ong, L., Tynan, R. J., Walker, F. R. and Hodgson, D. M.. 2011. "Epigenetic Inheritance of Anxiety-Like Behaviour in Rats - Role of Early Life Exposure to a Bacterial Mimetic." Journal of Developmental Origins of Health and Disease. 2, pp. S109-S109.
Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice
Wynne, O., Horvat, J. C., Kim, R. Y., Ong, L. K., Smith, R., Hansbro, P. M., Clifton, V. L. and Hodgson, D. M.. 2011. "Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice." Brain, Behavior, and Immunity. 25 (6), pp. 1214-1222. https://doi.org/10.1016/j.bbi.2011.03.014
Sustained Phosphorylation of Tyrosine Hydroxylase at Serine 40 in VIVO
Ong, L. K., Sominsky, L., Walker, A. K., Hodgson, D. M., Goodchild, A. K., Bobrovskaya, L., Dickson, P. W. and Dunkley, P. R.. 2011. "Sustained Phosphorylation of Tyrosine Hydroxylase at Serine 40 in VIVO." 23rd Biennial Meeting of the International Society for Neurochemistry (2011). Athen, Greece 28 Aug - 01 Sep 2011 United Kingdom.
The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland
Ong, Lin Kooi, Bobrovskaya, Larisa, Walker, Frederick R., Day, Trevor A., Dickson, Phillip W. and Dunkley, Peter R.. 2011. "The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland." Neurochemical Research. 36 (1), pp. 27-33. https://doi.org/10.1007/s11064-010-0255-7
Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress
Ong, L., Guan, L., Stutz, B., Dickson, P., Dunkley, P. and Bobrovskaya, L.. 2010. "Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress." Journal of Neurochemistry. 115, pp. 77-77.
Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis
Bobrovskaya, Larisa, Damanhuri, Hanafi A., Ong, Lin Kooi, Schneider, Jennifer J., Dickson, Phillip W., Dunkley, Peter R. and Goodchild, Ann K.. 2010. "Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis." Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry. 57 (2), pp. 162-167. https://doi.org/10.1016/j.neuint.2010.05.009
The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats
Ong, L., Bobrovskaya, L., Walker, F., Day, Trevor, Dickson, P. and Dunkley, P.. 2009. "The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats." 22nd Biennial Meeting of the International Society for Neurochemistry & Asian Pacific Society for Neurochemistry (2009). South Korea 23 - 29 Aug 2009 United Kingdom.
Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?
O’Leary, Margaret A., Schneider, Jennifer J., Prakash Krishnan, Brian, Lavis, Christopher, McKendry, Amy, Ong, Lin Kooi and Isbister, Geoffrey K.. 2007. "Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?" Toxicon. 50 (2), pp. 206-213. https://doi.org/10.1016/j.toxicon.2007.03.014