Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease
Article
Article Title | Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease |
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ERA Journal ID | 212549 |
Article Category | Article |
Authors | Nassir, Che Mohd Nasril Che Mohd, Ghazali, Mazira Mohamad, Hashim, Sabarisah, Idris, Nur Suhaila, Yuen, Lee Si, Hui, Wong Jia, Norman, Haziq Hazman, Gau, Chuang Huei, Jayabalan, Nanthini, Na, Yuri, Feng, Linqing, Ong, Lin Kooi, Hamid, Hafizah Abdul, Ahamed, Haja Nazeer and Mustapha, Muzaimi |
Journal Title | Frontiers in Cardiovascular Medicine |
Journal Citation | 8, pp. 1-32 |
Article Number | 632131 |
Number of Pages | 32 |
Year | 24 Feb 2021 |
Publisher | Frontiers Research Foundation |
Place of Publication | Switzerland |
ISSN | 2297-055X |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fcvm.2021.632131 |
Web Address (URL) | https://www.frontiersin.org/articles/10.3389/fcvm.2021.632131/full |
Abstract | Cerebral small vessel disease (CSVD) represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger neuroinflammation and the subsequent neurodegenerative cascade. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, Alzheimer disease, and Parkinson disease. Despite being the most common neurodegenerative condition with cerebrocardiovascular axis, understanding about it remains poor. Interestingly, modifiable risk factors such as unhealthy diet including high intake of processed food, high-fat foods, and animal by-products are known to influence the non-neural peripheral events, such as in the gastrointestinal tract and cardiovascular stress through cellular inflammation and oxidation. One key outcome from such events, among others, includes the cellular activations that lead to elevated levels of endogenous cellular-derived circulating microparticles (MPs). MPs can be produced from various cellular origins including leukocytes, platelets, endothelial cells, microbiota, and microglia. MPs could act as microthrombogenic procoagulant that served as a plausible culprit for the vulnerable end-artery microcirculation in the brain as the end-organ leading to CSVD manifestations. However, little attention has been paid on the potential role of MPs in the onset and progression of CSVD spectrum. Corroboratively, the formation of MPs is known to be influenced by diet-induced cellular stress. Thus, this review aims to appraise the body of evidence on the dietary-related impacts on circulating MPs from non-neural peripheral origins that could serve as a plausible microthrombosis in CSVD manifestation as a precursor of neurodegeneration. Here, we elaborate on the pathomechanical features of MPs in health and disease states; relevance of dietary patterns on MP release; preclinical studies pertaining to diet-based MPs contribution to disease; MP level as putative surrogates for early disease biomarkers; and lastly, the potential of MPs manipulation with diet-based approach as a novel preventive measure for CSVD in an aging society worldwide. |
Keywords | cerebral small vessel disease; diet; microparticles; neurodegeneration; microthrombosis |
ANZSRC Field of Research 2020 | 320903. Central nervous system |
310104. Cell neurochemistry | |
Byline Affiliations | University of Science, Malaysia |
Nanyang Technological University, Singapore | |
Management and Science University (MSU), Malaysia | |
University Tunku Abdul Rahman, Malaysia | |
University of Queensland | |
Korea Institute of Science and Technology (KIST), South Korea | |
University of Newcastle | |
Hunter Medical Research Institute, Australia | |
National Health and Medical Research Council, Australia | |
Monash University | |
University of Putra Malaysia, Malaysia | |
B.S. Abdur Rahman Crescent Institute of Science and Technology, India | |
Hospital University Science Malaysia, Malaysia |
https://research.usq.edu.au/item/y8342/diets-and-cellular-derived-microparticles-weighing-a-plausible-link-with-cerebral-small-vessel-disease
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