Dr Lin Ong

Dr Lin Ong
NameDr Lin Ong
Email Addresslin.ong@unisq.edu.au
Job TitleSenior Lecturer (Biomedical Science)
QualificationsBBioSc Newcastle, BBiomedSc(Hons) Newcastle, PhD Newcastle
DepartmentSchool of Health and Medical Sciences
AffiliationsCentre for Health Research
ORCIDhttps://orcid.org/0000-0001-8664-0540
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BBioSc
Newcastle
2008
BBiomedSc(Hons)
Newcastle
2008
PhD
Newcastle
2012

Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke

Ong, Lin Kooi. 2022. "Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke." International Journal of Molecular Sciences. 23 (24), pp. 1-3. https://doi.org/10.3390/ijms232416024

Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice

Sanchez-Bezanilla, Sonia, Beard, Daniel J., Hood, Rebecca J., Aberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jorgen and Ong, Lin Kooi. 2022. "Growth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice." Neural Plasticity. 2022, pp. 1-13. https://doi.org/10.1155/2022/9983042

Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?

Stuckey, Shannon M., Ong, Lin Kooi, Collins-Praino, Lyndsey E. and Turner, Renee J.. 2021. "Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?" International Journal of Molecular Sciences. 22 (23), pp. 1-45. https://doi.org/10.3390/ijms222313101

More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke

Sanchez-Bezanilla, Sonia, Hood, Rebecca J., Collins-Praino, Lyndsey E., Turner, Renee J., Walker, Frederick R., Nilsson, Michael and Ong, Lin Kooi. 2021. "More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke." Journal of Cerebral Blood Flow and Metabolism. 41 (9), pp. 2439-2455. https://doi.org/10.1177/0271678X211005877

The Macrobrachiumrosenbergii nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention

Chen, Ken Fong, Tan, Wen Siang, Ong, Lin Kooi, Abidin, Syafiq Asnawi Zainal, Othman, Iekhsan, Tey, Beng Ti and Lee, Ronald Fook Seng. 2021. "The Macrobrachiumrosenbergii nodavirus: a detailed review of structure, infectivity, host immunity, diagnosis and prevention." Reviews in Aquaculture. 13 (4), pp. 2117-2141. https://doi.org/10.1111/raq.12562

Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease

Gasparotto, Juciano, Senger, Mario Roberto, de Sa Moreira, Emilio Telles, Brum, Pedro Ozorio, Kessler, Flavio Gabriel Carazza, Peixoto, Daniel Oppermann, Panzenhagen, Alana Castro, Ong, Lin Kooi, Soares, Marlene Campos, Reis, Patricia Alves, Schirato, Giuliana Viegas, Valente, Walter Cesar Goes, Montoya, Bogar Omar Araujo, Silva, Floriano P., Moreira, Jose Claudio Fonseca, Dal-Pizzol, Felipe, Castro-Faria-Neto, Hugo C. and Gelain, Daniel Pens. 2021. "Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease." Journal of Biological Chemistry. 297 (2), pp. 1-17. https://doi.org/10.1016/j.jbc.2021.100979

Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease

Lee, Natasha Ting, Ong, Lin Kooi, Gyawali, Prajwal, Nassir, Che Mohd Nasril Che Mohd, Mustapha, Muzaimi, Nandurkar, Harshal H. and Sashindranath, Maithili. 2021. "Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease." Biomolecules. 11 (7). https://doi.org/10.3390/biom11070994

Corticosterone Administration Alters White Matter Tract Structure and Reduces Gliosis in the Sub-Acute Phase of Experimental Stroke

Zalewska, Katarzyna, Hood, Rebecca J., Pietrogrande, Giovanni, Sanchez-Bezanilla, Sonia, Ong, Lin Kooi, Johnson, Sarah J., Young, Kaylene M., Nilsson, Michael and Walker, Frederick R.. 2021. "Corticosterone Administration Alters White Matter Tract Structure and Reduces Gliosis in the Sub-Acute Phase of Experimental Stroke." International Journal of Molecular Sciences. 22 (13), pp. 1-15. https://doi.org/10.3390/ijms22136693

Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra

Ong, Lin Kooi, Briggs, Gabrielle D., Guan, Liying, Dunkley, Peter R. and Dickson, Phillip W.. 2021. "Peripheral inflammation induces long-term changes in tyrosine hydroxylase activation in the substantia nigra." Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry. 146, pp. 1-10. https://doi.org/10.1016/j.neuint.2021.105022

Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms

Zhao, Zidan, Hood, Rebecca J., Ong, Lin Kooi, Pietrogrande, Giovanni, Sanchez Bezanilla, Sonia, Warren, Kirby E., Ilicic, Marina, Kluge, Murielle G., TeBay, Clifford, Ottersen, Ole P., Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2021. "Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms." Frontiers in Neurology. 12, pp. 1-14. https://doi.org/10.3389/fneur.2021.585189

Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task

Chow, Wei Zhen, Ong, Lin Kooi, Kluge, Murielle G., Gyawali, Prajwal, Walker, Frederick R. and Nilsson, Michael. 2020. "Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task." Scientific Reports. 10, pp. 1-8. https://doi.org/10.1038/s41598-020-76560-x

Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study

Gyawali, Prajwal, Hinwood, Madeleine, Chow, Wei Zhen, Kluge, Murielle, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study." Brain, Behavior, & Immunity - Health. 9, pp. 1-6. https://doi.org/10.1016/j.bbih.2020.100157

Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study

Gyawali, Prajwal, Chow, Wei Zhen, Hinwood, Madeleine, Kluge, Murielle, English, Coralie, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study." Frontiers in Neurology. 11, pp. 1-12. https://doi.org/10.3389/fneur.2020.00230

Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration

Kluge, Murielle G., Kracht, Laura, Mahmoud Abdolhoseini, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration." Glia. 65 (12), pp. 1885-1899. https://doi.org/10.1002/glia.23201

Oral corticosterone administration alone is sufficient to simulate the actions of chronic stress on glial cells but not on vasculature

Zalewska, K., Ong, L. K., Pietrogrande, G., Johnson, S. J., Nilsson, M. and Walker, F. R.. 2017. "Oral corticosterone administration alone is sufficient to simulate the actions of chronic stress on glial cells but not on vasculature." 13th European Meeting on Glial Cells in Health and Disease (2017). Scotland 08 - 11 Jul 2017 United States.

Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke

Zalewska, Katarzyna, Ong, Lin Kooi, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke." Neuroscience. 352, pp. 30-38. https://doi.org/10.1016/j.neuroscience.2017.03.005

Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons

Ong, Lin Kooi, Fuller, Erin A., Sominsky, Luba, Hodgson, Deborah M., Dunkley, Peter R. and Dickson, Phillip W.. 2017. "Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons." Scientific Reports. 7, pp. 1-6. https://doi.org/10.1038/srep40475

Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla

Ong, Lin Kooi, Page, Scott, Briggs, Gabrielle D., Guan, Liying, Dun, Matthew D., Verrills, Nicole M., Dunkley, Peter R. and Dickson, Phillip W.. 2017. "Peripheral Lipopolysaccharide Challenge Induces Long-Term Changes in Tyrosine Hydroxylase Regulation in the Adrenal Medulla." Journal of Cellular Biochemistry. 118 (8), pp. 2096-2107. https://doi.org/10.1002/jcb.25839

Authors’ response re: ‘‘Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?” by Ong et al. Brain Behavior and Immunity, 2016

Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick R.. 2017. "Authors’ response re: ‘‘Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend of foe?” by Ong et al. Brain Behavior and Immunity, 2016." Brain, Behavior, and Immunity. 60, pp. 384-384. https://doi.org/10.1016/j.bbi.2016.11.029

Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, TeBay, Clifford, Zalewska, Katarzyna, Dickson, Phillip W., Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R.. 2017. "Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?" Brain, Behavior, and Immunity. 60, pp. 117-125. https://doi.org/10.1016/j.bbi.2016.10.001

Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice

Ong, Lin Kooi, Zhao, Zidan, Kluge, Murielle, Walker, Frederick R. and Nilsson, Michael. 2017. "Chronic stress exposure following photothrombotic stroke is associated with increased levels of Amyloid beta accumulation and altered oligomerisation at sites of thalamic secondary neurodegeneration in mice." Journal of Cerebral Blood Flow and Metabolism. 37 (4), pp. 1338-1348. https://doi.org/10.1177/0271678X16654920

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum

James, Morgan H., Quinn, Rikki K., Ong, Lin Kooi, Levi, Emily M., Smith, Doug W., Dickson, Phillip W. and Dayas, Christopher V.. 2016. "Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum." European Journal of Pharmacology. 784, pp. 147-154. https://doi.org/10.1016/j.ejphar.2016.05.013

Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese

Peres, Tanara V., Ong, Lin K., Costa, Ana Paula, Eyng, Helena, Venske, De´bora K. R., Colle, Dirleise, Gonçalves, Filipe M., Lopes, Mark W., Farina, Marcelo, Aschner, Michael, Dickson, Phillip W., Dunkley, Peter R. and Leal, Rodrigo B.. 2016. "Tyrosine hydroxylase regulation in adult rat striatum following short-term neonatal exposure to manganese." Metallomics: integrated biometal science. 8 (6), pp. 597-604. https://doi.org/10.1039/c5mt00265f

Inflammation and dopamine synthesis in neurodegeneration

Ong, Lin Kooi, Briggs, G., Guan, L., Dunkley, P. and Dickson, P.. 2015. "Inflammation and dopamine synthesis in neurodegeneration." 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society (2015). Cairns, Australia 23 - 27 Aug 2015 United Kingdom.

The role of inflammation and dopamine synthesis in Parkinson's disease

Ong, L. K., Briggs, G. D., Dunkley, P. R. and Dickson, P. W.. 2014. "The role of inflammation and dopamine synthesis in Parkinson's disease." 12th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry (2014). Taiwan 23 - 26 Aug 2014 United Kingdom.

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIa Levels

James, Morgan H., Quinn, Rikki K., Ong, Lin Kooi, Levi, Emily M., Charnley, Janine L., Smith, Doug W., Dickson, Phillip W. and Dayas, Christopher V.. 2014. "mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIa Levels." Neuropsychopharmacology. 39 (7), pp. 1694-1702. https://doi.org/10.1038/npp.2014.16

Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla

Ong, Lin Kooi, Guan, Liying, Damanhuri, Hanafi, Goodchild, Ann K., Bobrovskaya, Larisa, Dickson, Phillip W. and Dunkley, Peter R.. 2014. "Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla." Journal of Neurochemistry. 128 (4), pp. 547-560. https://doi.org/10.1111/jnc.12482

Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety

Sominsky, Luba, Fuller, Erin A., Bondarenko, Evgeny, Ong, Lin Kooi, Averell, Lee, Nalivaiko, Eugene, Dunkley, Peter R., Dickson, Phillip W. and Hodgson, Deborah M.. 2013. "Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety." PLoS One. 8 (3), pp. 1-13. https://doi.org/10.1371/journal.pone.0057700

Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner

Bobrovskaya, Larisa, Maniam, Jayanthi, Ong, Lin Kooi, Dunkley, Peter R. and Morris, Margaret J.. 2013. "Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner." Neurochemical Research. 38 (4), pp. 826-833. https://doi.org/10.1007/s11064-013-0985-4

Tyrosine Hydroxylase Phosphorylation in Catecholaminergic Brain Regions: A Marker of Activation following Acute Hypotension and Glucoprivation

Damanhuri, Hanafi A., Burke, Peter G. R., Ong, Lin K., Bobrovskaya, Larisa, Dickson, Phillip W., Dunkley, Peter R. and Goodchild, Ann K.. 2012. "Tyrosine Hydroxylase Phosphorylation in Catecholaminergic Brain Regions: A Marker of Activation following Acute Hypotension and Glucoprivation." PLoS One. 7 (11), pp. 1-19. https://doi.org/10.1371/journal.pone.0050535

The Sustained Phase of Tyrosine Hydroxylase Activation In vivo

Ong, Lin Kooi, Sominsky, Luba, Dickson, Phillip W., Hodgson, Deborah M. and Dunkley, Peter R.. 2012. "The Sustained Phase of Tyrosine Hydroxylase Activation In vivo." Neurochemical Research. 37 (9), pp. 1938-1943. https://doi.org/10.1007/s11064-012-0812-3

Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic

Sominsky, L., Walker, A. K., Ong, L. K., Tynan, R. J., Walker, F. R. and Hodgson, D. M.. 2012. "Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic." Behavioural Brain Research. 226 (1), pp. 351-356. https://doi.org/10.1016/j.bbr.2011.08.038

Epigenetic Inheritance of Anxiety-Like Behaviour in Rats - Role of Early Life Exposure to a Bacterial Mimetic

Sominsky, L., Walker, A. K., Ong, L., Tynan, R. J., Walker, F. R. and Hodgson, D. M.. 2011. "Epigenetic Inheritance of Anxiety-Like Behaviour in Rats - Role of Early Life Exposure to a Bacterial Mimetic." Journal of Developmental Origins of Health and Disease. 2, pp. S109-S109.

Sustained Phosphorylation of Tyrosine Hydroxylase at Serine 40 in VIVO

Ong, L. K., Sominsky, L., Walker, A. K., Hodgson, D. M., Goodchild, A. K., Bobrovskaya, L., Dickson, P. W. and Dunkley, P. R.. 2011. "Sustained Phosphorylation of Tyrosine Hydroxylase at Serine 40 in VIVO." 23rd Biennial Meeting of the International Society for Neurochemistry (2011). Athen, Greece 28 Aug - 01 Sep 2011 United Kingdom.

The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland

Ong, L. K., Guan, L., Stutz, B., Dickson, P. W., Dunkley, P. R. and Bobrovskaya, L.. 2011. "The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland." Neuroscience. 192, pp. 20-27. https://doi.org/10.1016/j.neuroscience.2011.06.087

Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice

Wynne, O., Horvat, J. C., Kim, R. Y., Ong, L. K., Smith, R., Hansbro, P. M., Clifton, V. L. and Hodgson, D. M.. 2011. "Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice." Brain, Behavior, and Immunity. 25 (6), pp. 1214-1222. https://doi.org/10.1016/j.bbi.2011.03.014

Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress

Ong, L., Guan, L., Stutz, B., Dickson, P., Dunkley, P. and Bobrovskaya, L.. 2010. "Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress." Journal of Neurochemistry. 115, pp. 77-77.

The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland

Ong, Lin Kooi, Bobrovskaya, Larisa, Walker, Frederick R., Day, Trevor A., Dickson, Phillip W. and Dunkley, Peter R.. 2011. "The Effect of Social Defeat on Tyrosine Hydroxylase Phosphorylation in the Rat Brain and Adrenal Gland." Neurochemical Research. 36 (1), pp. 27-33. https://doi.org/10.1007/s11064-010-0255-7

Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis

Bobrovskaya, Larisa, Damanhuri, Hanafi A., Ong, Lin Kooi, Schneider, Jennifer J., Dickson, Phillip W., Dunkley, Peter R. and Goodchild, Ann K.. 2010. "Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis." Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry. 57 (2), pp. 162-167. https://doi.org/10.1016/j.neuint.2010.05.009

Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?

O’Leary, Margaret A., Schneider, Jennifer J., Prakash Krishnan, Brian, Lavis, Christopher, McKendry, Amy, Ong, Lin Kooi and Isbister, Geoffrey K.. 2007. "Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?" Toxicon. 50 (2), pp. 206-213. https://doi.org/10.1016/j.toxicon.2007.03.014

The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats

Ong, L., Bobrovskaya, L., Walker, F., Day, Trevor, Dickson, P. and Dunkley, P.. 2009. "The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats." 22nd Biennial Meeting of the International Society for Neurochemistry & Asian Pacific Society for Neurochemistry (2009). South Korea 23 - 29 Aug 2009 United Kingdom.