Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study
Article
Kou, Kou, Cameron, Jessica, Youl, Philippa, Pyke, Christopher, Chambers, Suzanne, Dunn, Jeff, Aitken, Joanne F. and Baade, Peter D.. 2023. "Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study." Breast Cancer. 30 (3), pp. 466-477. https://doi.org/10.1007/s12282-023-01439-4
| Article Title | Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study |
|---|---|
| ERA Journal ID | 44823 |
| Article Category | Article |
| Authors | Kou, Kou, Cameron, Jessica, Youl, Philippa, Pyke, Christopher, Chambers, Suzanne, Dunn, Jeff, Aitken, Joanne F. and Baade, Peter D. |
| Journal Title | Breast Cancer |
| Journal Citation | 30 (3), pp. 466-477 |
| Number of Pages | 12 |
| Year | 2023 |
| Publisher | Springer |
| Place of Publication | Japan |
| ISSN | 1340-6868 |
| 1880-4233 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s12282-023-01439-4 |
| Web Address (URL) | https://link.springer.com/article/10.1007/s12282-023-01439-4 |
| Abstract | Background: Interval breast cancers (BC) are those diagnosed within 24 months of a negative mammogram. This study estimates the odds of being diagnosed with high-severity BC among screen-detected, interval, and other symptom-detected BC (no screening history within 2 years); and explores factors associated with being diagnosed with interval BC. Methods: Telephone interviews and self-administered questionnaires were conducted among women (n = 3,326) diagnosed with BC in 2010–2013 in Queensland. Respondents were categorised into screen-detected, interval, and other symptom-detected BCs. Data were analysed using logistic regressions with multiple imputation. Results: Compared with screen-detected BC, interval BC had higher odds of late-stage (OR = 3.50, 2.9–4.3), high-grade (OR = 2.36, 1.9–2.9) and triple-negative cancers (OR = 2.55, 1.9–3.5). Compared with other symptom-detected BC, interval BC had lower odds of late stage (OR = 0.75, 0.6–0.9), but higher odds of triple-negative cancers (OR = 1.68, 1.2–2.3). Among women who had a negative mammogram (n = 2,145), 69.8% were diagnosed at their next mammogram, while 30.2% were diagnosed with an interval cancer. Those with an interval cancer were more likely to have healthy weight (OR = 1.37, 1.1–1.7), received hormone replacement therapy (2–10 years: OR = 1.33, 1.0–1.7; > 10 years: OR = 1.55, 1.1–2.2), conducted monthly breast self-examinations (BSE) (OR = 1.66, 1.2–2.3) and had previous mammogram in a public facility (OR = 1.52, 1.2–2.0). Conclusion: These results highlight the benefits of screening even among those with an interval cancer. Women-conducted BSE were more likely to have interval BC which may reflect their increased ability to notice symptoms between screening intervals. |
| Keywords | Breast cancer; Interval cancer; Mammogram screening; Severity; Risk factors |
| ANZSRC Field of Research 2020 | 321102. Cancer diagnosis |
| Byline Affiliations | Cancer Council Queensland, Australia |
| Queensland University of Technology | |
| Metro South Hospital and Health Service, Queensland | |
| Mater Hospitals, Australia | |
| University of Technology Sydney | |
| Prostate Cancer Foundation of Australia | |
| University of Queensland | |
| Institute for Resilient Regions | |
| Griffith University |
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https://research.usq.edu.au/item/z261y/severity-and-risk-factors-of-interval-breast-cancer-in-queensland-australia-a-population-based-study
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