Deciding to enrol in a cancer trial: a systematic review of qualitative studies
Article
Article Title | Deciding to enrol in a cancer trial: a systematic review of qualitative studies |
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ERA Journal ID | 123846 |
Article Category | Article |
Authors | Viljoen, Bianca (Author), Chambers, Suzanne (Author), Dunn, Jeff (Author), Ralph, Nicholas (Author) and March, Sonja (Author) |
Journal Title | Journal of Multidisciplinary Healthcare |
Journal Citation | 13, pp. 1257-1281 |
Number of Pages | 25 |
Year | 2020 |
Place of Publication | United Kingdom |
ISSN | 1178-2390 |
Digital Object Identifier (DOI) | https://doi.org/10.2147/JMDH.S266281 |
Web Address (URL) | https://www.dovepress.com/deciding-to-enrol-in-a-cancer-trial-a-systematic-review-of-qualitative-peer-reviewed-fulltext-article-JMDH |
Abstract | Background: Clinical trials are essential for the advancement of cancer treatments; however, participation by patients is suboptimal. Currently, there is a lack of synthesized qualitative review evidence on the patient experience of trial entry from which to further develop decision support. The aim of this review is to synthesise literature reporting experiences of participants when deciding to enrol in a cancer clinical trial in order to inform practice. Methods: A systematic review and meta-synthesis of qualitative studies were conducted to describe the experiences of adult cancer patients who decided to enrol in a clinical trial of an anti-cancer treatment. Results: Forty studies met eligibility criteria for inclusion. Three themes were identified representing the overarching domains of experience when deciding to enrol in a cancer trial: 1) need for trial information; (2) trepidation towards participation; and (3) justifying the decision. The process of deciding to enrol in a clinical trial is one marked by uncertainty, emotional distress and driven by the search for a cure. Conclusion: Findings from this review show that decision support modelled by shared decision-making and the quality of a shared decision needs to be accompanied by tailored or personalised psychosocial and supportive care. Although the decision process bears similarities to theoretical processes outlined in decision-making frameworks, there are a lack of supportive interventions for cancer patients that are adapted to the clinical trial context. Theory-based interventions are urgently required to support the specific needs of patients deciding whether to participate in cancer trials. |
Keywords | advanced cancer, qualitative, guideline development, consolidated framework for implementation research |
Related Output | |
Is part of | Supportive care needs of men with advanced prostate cancer enrolled in a clinical trial |
ANZSRC Field of Research 2020 | 520302. Clinical psychology |
420699. Public health not elsewhere classified | |
Public Notes | This article is part of a UniSQ Thesis by publication. See Related Output. |
Byline Affiliations | School of Nursing and Midwifery |
Centre for Health Research | |
School of Psychology and Counselling | |
Institution of Origin | University of Southern Queensland |
Funding source | NHMRC |
https://research.usq.edu.au/item/q6291/deciding-to-enrol-in-a-cancer-trial-a-systematic-review-of-qualitative-studies
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Published Version
Viljoen et al. (2020). Deciding to Enrol in A Cancer Trial. Published Review.pdf | ||
License: CC BY | ||
File access level: Anyone |
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