A Pilot Epigenome-Wide Study of Posttraumatic Growth: Identifying Novel Candidates for Future Research
Article
| Article Title | A Pilot Epigenome-Wide Study of Posttraumatic Growth: Identifying Novel Candidates for Future Research |
|---|---|
| ERA Journal ID | 212406 |
| Article Category | Article |
| Authors | Rubens, Mackenzie, Pinto, Paul Ruiz, Sathyanarayanan, Anita, Miller, Olivia, Mullens, Amy B., Bruenig, Dagmar, Obst, Patricia, Shakespeare-Finch, Jane and Mehta, Divya |
| Journal Title | Epigenomes |
| Journal Citation | 9 (4) |
| Article Number | 39 |
| Number of Pages | 18 |
| Year | 2025 |
| Publisher | MDPI AG |
| Place of Publication | Switzerland |
| ISSN | 2075-4655 |
| Digital Object Identifier (DOI) | https://doi.org/10.3390/epigenomes9040039 |
| Web Address (URL) | https://www.mdpi.com/2075-4655/9/4/39 |
| Abstract | Background: Posttraumatic growth (PTG) refers to positive psychological change following trauma. While its psychological aspects are well-documented, the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may offer insight into PTG’s neurobiological basis. Aims: This study aimed to identify epigenetic markers associated with PTG using an epigenome-wide association study (EWAS), the first of its kind in a trauma-exposed population. Methods: A longitudinal EWAS design was used to assess DNAm before and after trauma exposure in first-year paramedicine students (n = 39). Genome-wide methylation data were analyzed for associations with PTG, applying epigenome-wide and gene-wise statistical thresholds. Pathway enrichment analysis was also conducted. Results: The study identified two CpGs (cg09559117 and cg05351447) within the PCDHA1/PCDHA2 and PDZD genes significantly associated with PTG at the epigenome-wide threshold (p < 9.42 × 10–8); these were replicated in an independent sample. DNAm in 5 CpGs across known PTSD candidate genes ANK3, DICER1, SKA2, IL12B and TPH1 were significantly associated with PTG after gene-wise Bonferroni correction. Pathway analysis revealed that PTG-associated genes were overrepresented in the Adenosine triphosphate Binding Cassette (ABC) transporters pathway (p = 2.72 × 10−4). Conclusions: These results identify genes for PTG, improving our understanding of the neurobiological underpinnings of PTG. |
| Keywords | posttraumatic stress disorder; posttraumatic growth; DNA methylation; EWAS; stress |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 520302. Clinical psychology |
| 320699. Medical biotechnology not elsewhere classified | |
| 420199. Allied health and rehabilitation science not elsewhere classified | |
| Byline Affiliations | Queensland University of Technology |
| School of Psychology and Wellbeing |
https://research.usq.edu.au/item/1001zv/a-pilot-epigenome-wide-study-of-posttraumatic-growth-identifying-novel-candidates-for-future-research
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