Cationic polymers in the central nervous system: Past, present and future

Edited book (chapter)

Mathew, Asha, Morey, Mangesh and Pandit, Abhay. 2015. "Cationic polymers in the central nervous system: Past, present and future." Samal, Sangram K. and Dubruel, Peter (ed.) Cationic polymers in Regenerative medicine. United Kingdom. Royal Society of Chemistry (RSC). pp. 463-478

Chapter Title	Cationic polymers in the central nervous system: Past, present and future
Book Chapter Category	Edited book (chapter)
Book Title	Cationic polymers in Regenerative medicine
Authors	Mathew, Asha, Morey, Mangesh and Pandit, Abhay
Editors	Samal, Sangram K. and Dubruel, Peter
Page Range	463-478
Series	Polymer Chemistry Series
Chapter Number	17
Number of Pages	16
Year	2015
Publisher	Royal Society of Chemistry (RSC)
Place of Publication	United Kingdom
ISBN	9781849739375
Digital Object Identifier (DOI)	https://doi.org/10.1039/9781782620105-00463
Web Address (URL)	https://books.rsc.org/books/edited-volume/1308/chapter-abstract/940727/Cationic-Polymers-in-the-Central-Nervous-System?redirectedFrom=fulltext
Abstract	Gene therapy has immense potential to manage the burden of neurological problems. Gene therapy to the central nervous system can be accomplished either by using a viral or a non-viral vector. Non-viral vectors are superior to viral vectors in terms of their safety profiles. However, their significantly low transfection efficiency is a major concern in the development of sustained non-viral gene therapy to the brain. The post-mitotic nature of neurons and the ability of non-viral vectors to cross the blood–brain barrier are the two challenging tasks that have yet to be addressed. Here, in this review, we have summarized the list of cationic polymers used for gene delivery to the brain and associated challenges. Cationic polymers are positively charged molecules that have a ready affinity towards negatively charged DNA/RNA, which allows them to carry genes. Cationic polymers are good candidates for gene therapy in the brain; however, there is scope for improvement to make them better. Development of newer synthetic cationic polymers and modification of natural polymers is the future for brain gene delivery. A biomaterials approach will also help to improve gene therapy. Biomaterial scaffolds can provide gene delivery with a safe degradation profile as well as a depot system that will allow long-term therapeutic effects. Sustained gene therapy in the brain can be achieved by integration of efforts from biology, technology, engineering and nanotechnology.
ANZSRC Field of Research 2020	400302. Biomaterials
Public Notes	Files associated with this item cannot be displayed due to copyright restrictions.
Byline Affiliations	National University of Ireland, Ireland

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