Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration

Article

Mathew, Asha, Vaquette, Cedryck, Hashimi, Saeed, Rathnayake, Irani, Huygens, Flavia, Hutmacher, Dietmar and Ivanovski, Saso. 2017. "Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration." Advanced Healthcare Materials. 6 (10). https://doi.org/10.1002/adhm.201601345

Article Title	Antimicrobial and immunomodulatory surface-functionalized electrospun membranes for bone regeneration
ERA Journal ID	200106
Article Category	Article
Authors	Mathew, Asha, Vaquette, Cedryck, Hashimi, Saeed, Rathnayake, Irani, Huygens, Flavia, Hutmacher, Dietmar and Ivanovski, Saso
Journal Title	Advanced Healthcare Materials
Journal Citation	6 (10)
Article Number	1601345
Number of Pages	12
Year	2017
Publisher	John Wiley & Sons
Place of Publication	Germany
ISSN	2192-2640
	2192-2659
Digital Object Identifier (DOI)	https://doi.org/10.1002/adhm.201601345
Web Address (URL)	https://onlinelibrary.wiley.com/doi/10.1002/adhm.201601345
Abstract	Guided bone regeneration (GBR) is a surgical procedure utilizing occlusive membranes for providing space maintenance and enabling selective repopulation of the damaged area. While this technique is effective in regenerating bone, bacterial infiltration occurs frequently and can compromise the regenerative outcome. In this study, the authors describe the development and characterization of a GBR membrane made of medical grade polycaprolactone (mPCL) electrospun fibers with antibacterial and immunomodulatory properties. This is achieved by the immobilization of the antibiotic azithromycin into the membrane via a solvent evaporation technique leading to a sustained release of the drug over 14 d. In vitro testing shows that this controlled release of azithromycin is proficient at inhibiting the growth of Staphylococcus aureus for 14 d. Implantation of azithromycin loaded mPCL membrane in a rodent calvarial defect induces macrophage polarization toward the M2 phenotype after one week and results in significantly more bone regeneration eight weeks post-surgery. The results suggest that this antibacterial membrane should be effective at preventing infection and also impacts on the macrophage polarization enhancing bone regeneration. The drug loading technique developed in this study is simple, effective with a strong potential for clinical translation and can be applied to different types of scaffolds and implants for applications in craniofacial and orthopedics applications.
Keywords	Antimicrobial; bone; material; membranes
ANZSRC Field of Research 2020	400302. Biomaterials
Public Notes	Files associated with this item cannot be displayed due to copyright restrictions.
Byline Affiliations	Griffith University
	Queensland University of Technology

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