Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications
Article
Kumara, S. P. S. N. Buddhika Sampath, Senevirathne, S. W. M. Amal Ishantha, Mathew, Asha, Bray, Laura, Mirkhalaf, Mohammad and Yarlagadda, Prasad K.D.V.. 2023. "Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications." Nanomaterials. 13 (20). https://doi.org/10.3390/nano13202799
Article Title | Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications |
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ERA Journal ID | 211126 |
Article Category | Article |
Authors | Kumara, S. P. S. N. Buddhika Sampath, Senevirathne, S. W. M. Amal Ishantha, Mathew, Asha, Bray, Laura, Mirkhalaf, Mohammad and Yarlagadda, Prasad K.D.V. |
Journal Title | Nanomaterials |
Journal Citation | 13 (20) |
Article Number | 2799 |
Number of Pages | 34 |
Year | 2023 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2079-4991 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nano13202799 |
Web Address (URL) | https://www.mdpi.com/2079-4991/13/20/2799 |
Abstract | Bacterial infections and antibiotic resistance remain significant contributors to morbidity and mortality worldwide. Despite recent advances in biomedical research, a substantial number of medical devices and implants continue to be plagued by bacterial colonisation, resulting in severe consequences, including fatalities. The development of nanostructured surfaces with mechano-bactericidal properties has emerged as a promising solution to this problem. These surfaces employ a mechanical rupturing mechanism to lyse bacterial cells, effectively halting subsequent biofilm formation on various materials and, ultimately, thwarting bacterial infections. This review delves into the prevailing research progress within the realm of nanostructured mechano-bactericidal polymeric surfaces. It also investigates the diverse fabrication methods for developing nanostructured polymeric surfaces with mechano-bactericidal properties. We then discuss the significant challenges associated with each approach and identify research gaps that warrant exploration in future studies, emphasizing the potential for polymeric implants to leverage their distinct physical, chemical, and mechanical properties over traditional materials like metals. |
Keywords | antibacterial surfaces; antimicrobial; nanofabrication; nanostructured surfaces; polymeric implants |
ANZSRC Field of Research 2020 | 400302. Biomaterials |
Byline Affiliations | Queensland University of Technology |
School of Engineering |
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https://research.usq.edu.au/item/z30yx/progress-in-nanostructured-mechano-bactericidal-polymeric-surfaces-for-biomedical-applications
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