Comprehensive Contribution of Filament Thickness and Crosslinker Failure to the Rheological Property of F-actin Cytoskeleton
Article
| Article Title | Comprehensive Contribution of Filament Thickness and Crosslinker Failure to the Rheological Property of F-actin Cytoskeleton |
|---|---|
| ERA Journal ID | 210243 |
| Article Category | Article |
| Authors | Li, Tong, Liu, Ling, Hu, Dean, Oloyede, Adekunle, Xiao, Yin, Yarlagadda, Prasad and Gu, YuanTong |
| Journal Title | Cellular and Molecular Bioengineering |
| Journal Citation | 8 (2), pp. 278-284 |
| Number of Pages | 7 |
| Year | Jun 2015 |
| Publisher | Springer |
| Place of Publication | United States |
| ISSN | 1865-5025 |
| 1865-5033 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s12195-015-0382-y |
| Web Address (URL) | https://link.springer.com/article/10.1007/s12195-015-0382-y |
| Abstract | Rheological property of F-actin cytoskeleton is significant to the restructuring of cytoskeleton under a variety of cell activities. This study numerically validates the rheological property of F-actin cytoskeleton is not only a result of kinetic energy dissipation of F-actin, but also greatly depends on the configuration remodeling of networks structure. Both filament geometry and crosslinker properties can affect the remodeling of F-actin cytoskeleton. The crosslinker unbinding is found to dissipate energy and induce prominent stress relaxation in the F-actin adjacent to cross-linkages. Coupled with F-actin elasticity, the energy dissipation and stress relaxation are more significant in bundled F-actin networks than in single F-actin networks. |
| Keywords | F-actin networks; Crosslinker; Energy dissipation; Mechanics |
| ANZSRC Field of Research 2020 | 4003. Biomedical engineering |
| Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
| Byline Affiliations | Queensland University of Technology |
| Utah State University, United States | |
| Hunan University, China |
https://research.usq.edu.au/item/y181x/comprehensive-contribution-of-filament-thickness-and-crosslinker-failure-to-the-rheological-property-of-f-actin-cytoskeleton
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