Trans-scale Granular Modelling of Cytoskeleton: a Mini-Review
Article
Article Title | Trans-scale Granular Modelling of Cytoskeleton: a Mini-Review |
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ERA Journal ID | 44833 |
Article Category | Article |
Authors | Li, Tong, Yarlagadda, Prasad K. D. V., Oloyede, Adekunle, Thibbotuwawa, Namal and Gu, YuanTong |
Journal Title | Molecular and Cellular Biomechanics |
Journal Citation | 12 (1), pp. 17-35 |
Number of Pages | 20 |
Year | Mar 2015 |
Place of Publication | United States |
ISSN | 1556-5297 |
1556-5300 | |
Digital Object Identifier (DOI) | https://doi.org/10.3970/mcb.2015.012.017 |
Web Address (URL) | https://www.techscience.com/mcb/v12n1/28574 |
Abstract | Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated dynamic cellular processes. Fortunately, multiscale modelling provides a powerful simulation tool that can be used to study the mechanical properties of these soft hierarchical, biological systems. This paper reviews recent developments in hierarchical multiscale modeling technique that aimed at understanding cytoskeleton mechanics. Discussions are expanded with respects to cytoskeletal components including: intermediate filaments, microtubules and microfilament networks. The mechanical performance of difference cytoskeleton components are discussed with respect to their structural and material properties. Explicit granular simulation methods are adopted with different coarse-grained strategies for these cytoskeleton components and the simulation details are introduced in this review. |
Keywords | Cytoskeleton; Intermediate filament; Microtubules; Microfilament network; Mechanics; Multiscale |
Byline Affiliations | Queensland University of Technology |
https://research.usq.edu.au/item/w457z/trans-scale-granular-modelling-of-cytoskeleton-a-mini-review
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