TiO2 Nanostructures That Reduce the Infectivity of Human Respiratory Viruses Including SARS-CoV-2
Article
Article Title | TiO2 Nanostructures That Reduce the Infectivity of Human Respiratory Viruses Including SARS-CoV-2 |
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ERA Journal ID | 210028 |
Article Category | Article |
Authors | Jaggessar, Alka, Velic, Amar, Yarlagadda, Prasad KDV and Spann, Kirsten |
Journal Title | ACS Biomaterials Science and Engineering |
Journal Citation | 8 (7), pp. 2954-2959 |
Number of Pages | 6 |
Year | 2022 |
Publisher | American Chemical Society |
Place of Publication | United States |
ISSN | 2373-9878 |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acsbiomaterials.2c00326 |
Web Address (URL) | https://pubs.acs.org/doi/10.1021/acsbiomaterials.2c00326 |
Abstract | The rapid emergence and global spread of the COVID-19 causing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its subsequent mutated strains has caused unprecedented health, economic, and social devastation. Respiratory viruses such as SARS-CoV-2 can be transmitted through both direct and indirect channels, including aerosol respiratory droplets, contamination of inanimate surfaces (fomites), and direct person-to-person contact. Current methods of virus inactivation on surfaces include chemicals and biocides, and while effective, continuous and repetitive cleaning of all surfaces is not always viable. Recent work in the field of biomaterials engineering has established the antibacterial effects of hydrothermally synthesized TiO2 nanostructured surfaces against both Gram-negative and -positive bacteria. The current study investigates the effectiveness of said TiO2 nanostructured surfaces against two enveloped human coronaviruses, SARS-CoV-2 and HCoV-NL63, and nonenveloped HRV-16 for surface-based inactivation. Results show that structured surfaces reduced infectious viral loads of SARS-CoV-2 (5 log), HCoV-NL63 (3 log), and HRV-16 (4 log) after 5 h, compared to nonstructured and tissue culture plastic control surfaces. Interestingly, infectious virus remained present on control tissue culture plastic after 7 h exposure. These encouraging results establish the potential use of nanostructured surfaces to reduce the transmission and spread of both enveloped and nonenveloped respiratory viruses, by reducing their infectious period on a surface. The dual antiviral and antibacterial properties of these surfaces support their potential application in a wide variety of settings such as hospitals and healthcare environments, public transport and community hubs. |
Keywords | SARS-CoV-2; human coronavirus; nanostructured surfaces; titanium dioxide; HCoV-NL63; HRV-16; antiviral surfaces; antibacterial surfaces |
ANZSRC Field of Research 2020 | 4003. Biomedical engineering |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland University of Technology |
https://research.usq.edu.au/item/y1859/tio2-nanostructures-that-reduce-the-infectivity-of-human-respiratory-viruses-including-sars-cov-2
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