Analysis of strain-rate dependent mechanical behavior of single chondrocyte: a finite element study
Article
Article Title | Analysis of strain-rate dependent mechanical behavior of single chondrocyte: a finite element study |
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ERA Journal ID | 36477 |
Article Category | Article |
Authors | Gu, YuanTong (Author), Nguyen, Trung Dung (Author), Oloyede, Adekunle (Author) and Senadeera, Wijitha (Author) |
Journal Title | International Journal of Computational Methods |
Journal Citation | 11 (1 (Supplement)), pp. 1344005-1 |
Number of Pages | 20 |
Year | 2014 |
Publisher | World Scientific Publishing |
Place of Publication | Singapore |
ISSN | 0219-8762 |
1793-6969 | |
Digital Object Identifier (DOI) | https://doi.org/10.1142/S0219876213440052 |
Web Address (URL) | http://www.worldscientific.com/doi/abs/10.1142/S0219876213440052 |
Abstract | Various studies have been conducted to investigate the effects of impact loading on cartilage damage and chondrocyte death. These have shown that the rate and magnitude of the applied strain significantly influence chondrocyte death, and that cell death occurred mostly in the superficial zone of cartilage suggesting the need to further understand the fundamental mechanisms underlying the chondrocytes death induced at certain levels of strain-rate. To date there is no comprehensive study providing insight on this phenomenon. The aim of this study is to examine the strain-rate dependent behavior of a single chondrocyte using a computational approach based on finite element method (FEM). An FEM model was developed using various mechanical models, which were standard Neo-Hookean solid (SnHS), porohyperelastic (PHE) and poroviscohyperelastic(PVHE) to simulate atomic force microscopy (AFM) experiments of chondrocyte. The PVHE showed, it can capture both relaxation and loading rate dependent behaviors of chondrocytes, accurately compared to other models. |
Keywords | porohyperelastic; chondrocyte; finite element method (FEM); biomechanics |
ANZSRC Field of Research 2020 | 400303. Biomechanical engineering |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland University of Technology |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q3wy1/analysis-of-strain-rate-dependent-mechanical-behavior-of-single-chondrocyte-a-finite-element-study
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