Raffinose Family Oligosaccharides: Friend or Foe for Human and Plant Health?

Article

Elango, Dinakaran, Rajendran, Karthika, der Laan, Liza Van, Sebastiar, Sheelamary, Raigne, Joscif, Thaiparambil, Naveen A., Hadda, Noureddine, Raja, Bharath, Wang, Wanyan, Ferela, Antonella, Chiteri, Kevin O., Thudi, Mahendar, Varshney, Rajeev K., Chopra, Surinder, Sing, Arti and Singh, Asheesh K.. 2022. "Raffinose Family Oligosaccharides: Friend or Foe for Human and Plant Health?" Frontiers in Plant Science. 13. https://doi.org/10.3389/fpls.2022.829118
Article Title

Raffinose Family Oligosaccharides: Friend or Foe for Human and Plant Health?

ERA Journal ID200524
Article CategoryArticle
AuthorsElango, Dinakaran, Rajendran, Karthika, der Laan, Liza Van, Sebastiar, Sheelamary, Raigne, Joscif, Thaiparambil, Naveen A., Hadda, Noureddine, Raja, Bharath, Wang, Wanyan, Ferela, Antonella, Chiteri, Kevin O., Thudi, Mahendar, Varshney, Rajeev K., Chopra, Surinder, Sing, Arti and Singh, Asheesh K.
Journal TitleFrontiers in Plant Science
Journal Citation13
Article Number829118
Number of Pages16
Year2022
PublisherFrontiers Media SA
Place of PublicationSwitzerland
ISSN1664-462X
Digital Object Identifier (DOI)https://doi.org/10.3389/fpls.2022.829118
Web Address (URL)https://www.frontiersin.org/articles/10.3389/fpls.2022.829118/full
Abstract

Raffinose family oligosaccharides (RFOs) are widespread across the plant kingdom, and their concentrations are related to the environment, genotype, and harvest time. RFOs are known to carry out many functions in plants and humans. In this paper, we provide a comprehensive review of RFOs, including their beneficial and anti-nutritional properties. RFOs are considered anti-nutritional factors since they cause flatulence in humans and animals. Flatulence is the single most important factor that deters consumption and utilization of legumes in human and animal diets. In plants, RFOs have been reported to impart tolerance to heat, drought, cold, salinity, and disease resistance besides regulating seed germination, vigor, and longevity. In humans, RFOs have beneficial effects in the large intestine and have shown prebiotic potential by promoting the growth of beneficial bacteria reducing pathogens and putrefactive bacteria present in the colon. In addition to their prebiotic potential, RFOs have many other biological functions in humans and animals, such as anti-allergic, anti-obesity, anti-diabetic, prevention of non-alcoholic fatty liver disease, and cryoprotection. The wide-ranging applications of RFOs make them useful in food, feed, cosmetics, health, pharmaceuticals, and plant stress tolerance; therefore, we review the composition and diversity of RFOs, describe the metabolism and genetics of RFOs, evaluate their role in plant and human health, with a primary focus in grain legumes.

Keywordsa-galactosides; flatulence; galactinol synthase; prebiotic carbohydrates; grain legume crops
Byline AffiliationsIowa State University, United States
Vellore Institute of Technology, India
ICAR-Sugarcane Breeding Institute, India
International Center for Agricultural Research in the Dry Areas, Syria
Mohammed V University of Rabat, Morocco
Pennsylvania State University, United States
Centre for Crop Health
Dr. Rajendra Prasad Central Agricultural University, India
International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), India
Murdoch University
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