Product of serum calcium and phosphorus (Ca× PO4) as predictor of cardiovascular disease risk in predialysis patients

Article


Regmi, Prashant, Malla, Bimala, Gyawali, Prajwal, Sigdel, Manoj, Shrestha, Rojeet, Shah, Dibya Singh and Khanal, Madhav Prasad. 2014. "Product of serum calcium and phosphorus (Ca× PO4) as predictor of cardiovascular disease risk in predialysis patients." Clinical Biochemistry. 47 (1-2), pp. 77-81. https://doi.org/10.1016/j.clinbiochem.2013.09.012
Article Title

Product of serum calcium and phosphorus (Ca× PO4) as predictor of cardiovascular disease risk in predialysis patients

ERA Journal ID15237
Article CategoryArticle
AuthorsRegmi, Prashant, Malla, Bimala, Gyawali, Prajwal, Sigdel, Manoj, Shrestha, Rojeet, Shah, Dibya Singh and Khanal, Madhav Prasad
Journal TitleClinical Biochemistry
Journal Citation47 (1-2), pp. 77-81
Number of Pages5
YearJan 2014
PublisherElsevier
Place of PublicationUnited States
ISSN0009-9120
1873-2933
Digital Object Identifier (DOI)https://doi.org/10.1016/j.clinbiochem.2013.09.012
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0009912013004438
Abstract

Objectives
The mortality rate of chronic kidney disease (CKD) patients is very high due to cardiovascular diseases (CVD) which cannot be fully justified by traditional CVD markers. Since, mineral bone disorder is common in CKD, product of serum calcium and phosphorus (Ca × PO4) can be a predictor of future CVD. So, our study aims to assess the utility of higher Ca × PO4 in prediction of CVD risk in predialysis CKD patients.

Design and methods
150 CKD patients defined by NKF-KDOQI guideline not undergoing dialysis were recruited. Anthropometric and electrocardiographic parameters were recorded. We evaluated CVD risk by: i) Biochemical CVD markers, ii) NCEP ATP III guideline postulated risk factors and iii) Framingham risk scores.

Results
Higher Ca × PO4 is associated with presence of Left Ventricular Hypertrophy, oxidative stress, microinflammation, hyperhomocysteinemia, hypercholesterolemia, hypertriglyceridemia and increased LDLc. Compared to cases with Ca × PO4 < 55 mg2/dL2, cases with ≥ 55 mg2/dL2 had relative risk (RR) of 1.82 (95% CI 1.25-2.64) for CVD, 3.24 (95% CI 2.37-4.41) for stroke and 2.43 (95% CI 1.37-4.31) for coronary heart disease (CHD). Moreover, compared to lowest quartile of Ca x PO4, the highest quartile group had RR of 2.13 (95% CI 1.06-4.28) for CVD, 2.61(95% CI 1.80-3.75) for stroke and 2.84 (95% CI 1.15-7.0) for CHD.

Conclusion
In predialysis patients, higher Ca × PO4 is independent predictor of CVD risk.

KeywordsCalcium x phosphorus; Chronic kidney disease; Cardiovascular risk; Predialysis
ANZSRC Field of Research 2020320214. Nephrology and urology
320101. Cardiology (incl. cardiovascular diseases)
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsNepal Medical College, Nepal
Charité – Berlin University Medicine, Germany
Charles Sturt University
Manipal College of Medical Sciences, Nepal
Hokkaido University, Japan
TU Teaching Hospital, Nepal
Permalink -

https://research.usq.edu.au/item/yyq05/product-of-serum-calcium-and-phosphorus-ca-po4-as-predictor-of-cardiovascular-disease-risk-in-predialysis-patients

  • 36
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review
Mbah, Jovita I., Bwititi, Phillip T., Gyawali, Prajwal and Nwose, Ezekiel U.. 2024. "Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review." Cureus: Journal of Medical Science. 16 (7). https://doi.org/10.7759/cureus.64201
Blood Viscosity Changes in Diabetes Mellitus: A 20-Year Bibliometric Review and Future Directions
Mbah, Jovita I., Bwititi, Phillip T., Gyawali, Prajwal and Nwose, Ezekiel U.. 2024. "Blood Viscosity Changes in Diabetes Mellitus: A 20-Year Bibliometric Review and Future Directions." Cureus: Journal of Medical Science. 16 (7). https://doi.org/10.7759/cureus.64211
Association Between E-Cigarettes, Cognition and Mood in Adolescents
Novak, Marissa L., Gyawali, Prajwal and Wang, Grace. 2024. "Association Between E-Cigarettes, Cognition and Mood in Adolescents ." Substance Use and Misuse. https://doi.org/10.1080/10826084.2024.2383597
Photoperiod and metabolic health: evidence, mechanism, and implications
Regmi, Prashant, Young, Morag, Minigo, Gabriela, Milic, Natalie and Gyawali, Prajwal. 2024. "Photoperiod and metabolic health: evidence, mechanism, and implications." Metabolism: clinical and experimental. 152. https://doi.org/10.1016/j.metabol.2023.155770
Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke
Gyawali, Prajwal, Lillicrap, Thomas P., Garcia-Esperon, Carlos G., Bhattarai, Aseem, Bivard, Andrew and Spratt, Neil. 2024. "Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke." Seminars in Thrombosis and Hemostasis. 50 (4), pp. 580-591. https://doi.org/10.1055/s-0043-1775858
An Evaluation of Community Health Workers’ Knowledge, Attitude and Personal Lifestyle Behaviour in Non-Communicable Disease Health Promotion and Their Association with Self-Efficacy and NCD-Risk Perception
Yenit, Melaku Kindie, Kolbe-Alexander, Tracy L., Gelaye, Kassahun Alemu, Gezie, Lemma Derseh, Tesema, Getayeneh Antehunegn, Abebe, Solomon Mekonnen, Azale, Telake, Shitu, Kegnie and Gyawali, Prajwal. 2023. "An Evaluation of Community Health Workers’ Knowledge, Attitude and Personal Lifestyle Behaviour in Non-Communicable Disease Health Promotion and Their Association with Self-Efficacy and NCD-Risk Perception." International Journal of Environmental Research and Public Health. 20 (9). https://doi.org/10.3390/ijerph20095642
Editorial: Stress, mood, and fatigue: Tackling “invisible” obstacles in stroke rehabilitation and recovery
Gyawali, Prajwal, Wong, Dana, Hordacre, Brenton, Ong, Lin Kooi and English, Coralie. 2023. "Editorial: Stress, mood, and fatigue: Tackling “invisible” obstacles in stroke rehabilitation and recovery ." Frontiers in Neurology. 13. https://doi.org/10.3389/fneur.2022.1121667
Drug-Resistant Tuberculosis Stigma Among HealthCare Workers Toward the Development of a Stigma-Reduction Strategy: A Scoping Review
Aranas, Lolita Liboon, Alam, Khorshed, Gyawali, Prajwal and Mahumud, Rashidul Mahumud. 2023. "Drug-Resistant Tuberculosis Stigma Among HealthCare Workers Toward the Development of a Stigma-Reduction Strategy: A Scoping Review." Inquiry: the Journal of Health Care Organization Provision and Financing. 60, pp. 1-10. https://doi.org/10.1177/00469580231180754
Scoping review of molecular biomarkers associated with fatigue, stress, and depression in stroke survivors: A protocol
Potter, Tarynn, Gange, Nisal, Whiteside, Eliza and Gyawali, Prajwal. 2023. "Scoping review of molecular biomarkers associated with fatigue, stress, and depression in stroke survivors: A protocol." PLoS One. 18. https://doi.org/10.1371/journal.pone.0281238.
Examining Drug-Resistant Tuberculosis Stigma Among Health Care Workers Toward the Development of a Stigma-Reduction Intervention: Protocol for a Scoping Review
Aranas, Lolita Liboon, Alam, Khorshed, Gyawali, Prajwal and Mahumud, Rashidul Alam. 2023. "Examining Drug-Resistant Tuberculosis Stigma Among Health Care Workers Toward the Development of a Stigma-Reduction Intervention: Protocol for a Scoping Review ." JMIR Research Protocols. 12, p. e43084. https://doi.org/10.2196/43084
Successful health promotion, its challenges and the way forward in Nepal
Dhital, Madhu Koirala, Dhital, Shalik Ram, KC, Bhakta Bahadur, Owens, Vicki, Khadka, Hem Raj and Gyawali, Prajwal. 2022. "Successful health promotion, its challenges and the way forward in Nepal." Global Health Promotion. 30 (1), pp. 68-71. https://doi.org/10.1177/17579759221117792
Psychological Stress Management and Stress Reduction Strategies for Stroke Survivors: A Scoping Review
Hinwood, Madeleine, Ilicic, Marina, Gyawali, Prajwal, Coupland, Kirsten, Kluge, Murielle G., Smith, Angela, Bowden, Sue, Nilsson, Michael and Walker, Frederick Rohan. 2023. "Psychological Stress Management and Stress Reduction Strategies for Stroke Survivors: A Scoping Review." Annals of Behavioral Medicine. 57 (2), p. 111–130. https://doi.org/10.1093/abm/kaac002
Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study
Gyawali, Prajwal, Hinwood, Madeleine, Chow, Wei Zhen, Kluge, Murielle, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Exploring the relationship between fatigue and circulating levels of the pro-inflammatory biomarkers interleukin-6 and C-reactive protein in the chronic stage of stroke recovery: a cross-sectional study." Brain, Behavior, & Immunity - Health. 9, pp. 1-6. https://doi.org/10.1016/j.bbih.2020.100157
Dyslipidemia among Patients with Ischemic Stroke in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study
Baral, Sushil, Pokhrel, Asmita, Kumar B.K., Shyam, Kshetri, Rupesh, Regmi, Prashant and Gyawali, Prajwal. 2022. "Dyslipidemia among Patients with Ischemic Stroke in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study." Journal of the Nepal Medical Association. 60 (250), pp. 511-516. https://doi.org/10.31729/jnma.7491
Address an unmet need: establishing the prevalence of metabolic syndrome in Darling Down region
Gardiner, P., Aung, N., Ng, L., Stolic, S., Bliss, E., Gyawali, P. and Roberts, M.. 2022. "Address an unmet need: establishing the prevalence of metabolic syndrome in Darling Down region." Toowoomba, Darling Downs Health Services Research Symposium.
Cardiovascular Risk Assessment in Hemodialysis Patients
Pokhrel, Asmita, Pokhrel, Buddhi Raj, Gyawali, Prajwal, Regmi, Deepak, Khanal, Madhav, Bhattarai, Ashim, Poudel, Prakash and KC, Anuj. 2021. "Cardiovascular Risk Assessment in Hemodialysis Patients." Nepal Medical College Journal. 23 (3), pp. 252-258. https://doi.org/10.3126/nmcj.v23i3.40385
Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke
Gyawali, Prajwal, Lillicrap, Thomas Patrick, Tomari, Shinya, Bivard, Andrew, Holliday, Elizabeth, Parsons, Mark, Levi, Christopher, Garcia-Esperon, Carlos and Spratt, Neil. 2022. "Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke." Neurological Sciences. 43 (4), pp. 2375-2381. https://doi.org/10.1007/s10072-021-05666-5
Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease
Lee, Natasha Ting, Ong, Lin Kooi, Gyawali, Prajwal, Nassir, Che Mohd Nasril Che Mohd, Mustapha, Muzaimi, Nandurkar, Harshal H. and Sashindranath, Maithili. 2021. "Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease." Biomolecules. 11 (7). https://doi.org/10.3390/biom11070994
Acute Effects of Frequent Light-Intensity Standing-Based Exercises That Interrupt 8 Hours of Prolonged Sitting on Postprandial Glucose in Stroke Survivors: A Dose-Escalation Trial
Mackie, Paul, Crowfoot, Gary, Gyawali, Prajwal, Janssen, Heidi, Holliday, Elizabeth, Dunstan, David and English, Coralie. 2021. "Acute Effects of Frequent Light-Intensity Standing-Based Exercises That Interrupt 8 Hours of Prolonged Sitting on Postprandial Glucose in Stroke Survivors: A Dose-Escalation Trial." Journal of Physical Activity and Health. 18 (6), pp. 644-652. https://doi.org/10.1123/jpah.2020-0516
Time-efficient intervention to improve older adolescents’ cardiorespiratory fitness: findings from the ‘Burn 2 Learn’ cluster randomised controlled trial
Lubans, David R., Smith, Jordan J., Eather, Narelle, Leahy, Angus A., Morgan, Philip J., Lonsdale, Chris, Plotnikoff, Roland C., Nilsson, Michael, Kennedy, Sarah G., Holliday, Elizabeth G., Weaver, Natasha, Noetel, Michael, Shigeta, Tatsuya T., Mavilidi, Myrto F., Valkenborghs, Sarah R., Gyawali, Prajwal, Walker, Frederick R., Costigan, Sarah A. and Hillman, Charles H.. 2020. "Time-efficient intervention to improve older adolescents’ cardiorespiratory fitness: findings from the ‘Burn 2 Learn’ cluster randomised controlled trial." British Journal of Sports Medicine. https://doi.org/10.1136/bjsports-2020-103277
Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task
Chow, Wei Zhen, Ong, Lin Kooi, Kluge, Murielle G., Gyawali, Prajwal, Walker, Frederick R. and Nilsson, Michael. 2020. "Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task." Scientific Reports. 10, pp. 1-8. https://doi.org/10.1038/s41598-020-76560-x
Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples
Lillicrap, Thomas, Keragala, Charithani B., Draxler, Dominik F., Chan, Jilly, Ho, Heidi, Harman, Stevi, Niego, Be’eri, Holliday, Elizabeth, Levi, Christopher R., Garcia-Esperon, Carlos, Spratt, Neil, Gyawali, Prajwal, Bivard, Andrew, Parsons, Mark W., Montaner, Joan, Bustamante, Alejandro, Cadenas, Israel Fernandez, Cloud, Geoffrey, Maguire, Jane M., ..., Medcalf, Robert L.. 2020. "Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples." Frontiers in Neurology. 11, pp. 1-4. https://doi.org/10.3389/fneur.2020.589628
Prevalence of cardiovascular risk factors among chronic kidney disease patients undergoing hemodialysis in a tertiary care center, Kathmandu, Nepal
Pokhrel, A., Gyawali, P., Pokhrel, B. R., Khanal, M. P., Manandhar, D. N., Bwititi, P. and Nwose, E. U.. 2019. "Prevalence of cardiovascular risk factors among chronic kidney disease patients undergoing hemodialysis in a tertiary care center, Kathmandu, Nepal." Nepal Medical College Journal. 21 (4), pp. 313-318. https://doi.org/10.3126/nmcj.v21i4.27629
Accuracy of glucose meter among adults in a semi-urban area in Kathmandu, Nepal
Pokhrel, Asmita, Silvanus, Vinutha, Pokhrel, Buddhi Raj, Baral, Binaya, Khanal, Madhav, Gyawali, Prajwal, Pokhrel, Laxman and Regmi, Deepak. 2019. "Accuracy of glucose meter among adults in a semi-urban area in Kathmandu, Nepal." Nepal Medical Association Journal. 57 (216), pp. 104-108. https://doi.org/10.31729/jnma.4247
Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker
Gyawali, Prajwal, Richards, Ross S., Tinley, Paul, Nwose, Ezekiel Uba and Bwititi, Phillip T.. 2016. "Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker." Clinical Hemorheology and Microcirculation. 64 (1), pp. 1-5. https://doi.org/10.3233/CH-152033
Prediabetes and cardiovascular complications study (PACCS): international collaboration 4 years' summary and future direction
Nwose, E. U., Richards, R. S., Bwititi, P. T., Igumbor, E. O., Oshionwu, E. J., Okolie, K., Onyia, I. C., Pokhrel, A., Gyawali, P., Okuzor, J. N., Oguoma, V. M., Gardiner, F. W. and Wang, L.. 2017. "Prediabetes and cardiovascular complications study (PACCS): international collaboration 4 years' summary and future direction." BMC Research Notes. 10 (1). https://doi.org/10.1186/s13104-017-3017-7
Current research on cigarette toxicity: critical appraisal in view of clinical laboratory
Gyawali, Prajwal and Oguoma, Victor Maduabuchi. 2016. "Current research on cigarette toxicity: critical appraisal in view of clinical laboratory." International Journal of Research in Medical Sciences. 4 (6), pp. 1785-1793. https://doi.org/10.18203/2320-6012.ijrms20161725
School-based physical activity intervention for older adolescents: rationale and study protocol for the Burn 2 Learn cluster randomised controlled trial
Leahy, Angus A, Eather, Narelle, Smith, Jordan J, Hillman, Charles, Morgan, Philip J, Nilsson, Michael, Lonsdale, Chris, Plotnikoff, Ronald C, Noetel, Michael, Holliday, Elizabeth, Shigeta, Tatsuya T, Costigan, Sarah A, Walker, Frederick R, Young, Sarah, Valkenborghs, Sarah R, Gyawali, Prajwal, Harris, Nigel, Kennedy, Sarah G and Lubans, David R. 2019. "School-based physical activity intervention for older adolescents: rationale and study protocol for the Burn 2 Learn cluster randomised controlled trial." BMJ Open. 9 (5). https://doi.org/10.1136/bmjopen-2018-026029
Exploration of stress management interventions to address psychological stress in stroke survivors: A protocol for a scoping review
Hinwood, Madeleine, Ilicic, Marina, Gyawali, Prajwal, Kluge, Murielle Gabriela, Coupland, Kirsten, Smith, Angela, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Exploration of stress management interventions to address psychological stress in stroke survivors: A protocol for a scoping review." BMJ Open. 10 (3). https://doi.org/10.1136/bmjopen-2019-035592
Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study
Gyawali, Prajwal, Chow, Wei Zhen, Hinwood, Madeleine, Kluge, Murielle, English, Coralie, Ong, Lin Kooi, Nilsson, Michael and Walker, Frederick Rohan. 2020. "Opposing associations of stress and resilience with functional outcomes in stroke survivors in the chronic phase of stroke: A cross-sectional study." Frontiers in Neurology. 11, pp. 1-12. https://doi.org/10.3389/fneur.2020.00230
Cardiovascular risk screening options in diabetes: framework for selective adoption
Nwose, Ezekiel U., Digban, Kester A., Oshionwu, Echinei J., Onyia, Innocent C., Bwititi, Phillip T., Oguoma, Victor M., Anyasodor, Anayochukwu E. and Gyawali, Prajwal. 2016. "Cardiovascular risk screening options in diabetes: framework for selective adoption." National Journal of Community Medicine. 7 (6), pp. 540-544.
Comparison of lipid profile parameters and oxidized low-density lipoprotein between normal and preeclamptic pregnancies in a tertiary care hospital in Nepal
Timalsina, Santosh, Gyawali, Prajwal and Bhattarai, Aseem. 2016. "Comparison of lipid profile parameters and oxidized low-density lipoprotein between normal and preeclamptic pregnancies in a tertiary care hospital in Nepal." International Journal of Women's Health. 8, pp. 627-631. https://doi.org/10.2147/IJWH.S117850
Quantitative Measurement of Erythrocyte Aggregation as a Systemic Inflammatory Marker by Ultrasound Imaging: A Systematic Review
Gyawali, Prajwal, Ziegler, Daniela, Cailhier, Jean-Franois, Denault, Andre and Cloutier, Guy. 2018. "Quantitative Measurement of Erythrocyte Aggregation as a Systemic Inflammatory Marker by Ultrasound Imaging: A Systematic Review." Ultrasound in Medicine and Biology. 44 (7), pp. 1303-1317. https://doi.org/10.1016/j.ultrasmedbio.2018.02.020
Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome
Gyawali, Prajwal, Richards, Ross S., Bwititi, Phillip T. and Nwose, Ezekiel Uba. 2015. "Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome." Blood Cells, Molecules and Diseases. 54 (4), pp. 360-363. https://doi.org/10.1016/j.bcmd.2015.01.005
The association of dyslipidemia with erythrocyte aggregation
Gyawali, Prajwal, Richards, Ross S, Bwititi, Phillip T. and Nwose, Ezekiel Uba. 2015. "The association of dyslipidemia with erythrocyte aggregation ." Clinical Lipidology. 10 (2), pp. 129-135. https://doi.org/10.2217/CLP.15.3
Hemorheology, ankle brachial pressure index (ABPI) and toe brachial pressure index (TBPI) in metabolic syndrome
Gyawali, Prajwal, Richards, Ross S., Tinley, Paul and Nwose, Ezekiel Uba. 2014. "Hemorheology, ankle brachial pressure index (ABPI) and toe brachial pressure index (TBPI) in metabolic syndrome ." Microvascular Research. 95, pp. 31-36. https://doi.org/10.1016/j.mvr.2014.06.013
Erythrocyte aggregation and metabolic syndrome
Gyawali, Prajwal, Richards, Ross S., Hughes, Diane L. and Tinley, Paul. 2014. "Erythrocyte aggregation and metabolic syndrome." Clinical Hemorheology and Microcirculation. 57 (1), pp. 73-83. https://doi.org/10.3233/CH-131792
Whole-blood viscosity and metabolic syndrome
Gyawali, Prajwal, Richards, Ross S, Nwose, Ezekiel Uba and Bwititi, Phillip T. 2012. "Whole-blood viscosity and metabolic syndrome ." Clinical Lipidology. 7 (6), pp. 709-719. https://doi.org/10.2217/CLP.12.65
Erythrocyte morphology in metabolic syndrome
Gyawali, Prajwal, Richards, Ross S. and Nwose, Ezekiel Uba. 2012. "Erythrocyte morphology in metabolic syndrome ." Expert Review of Hematology. 5 (5), pp. 523-531. https://doi.org/10.1586/EHM.12.47