Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke
Article
Gyawali, Prajwal, Lillicrap, Thomas P., Garcia-Esperon, Carlos G., Bhattarai, Aseem, Bivard, Andrew and Spratt, Neil. 2024. "Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke." Seminars in Thrombosis and Hemostasis. 50 (4), pp. 580-591. https://doi.org/10.1055/s-0043-1775858
Article Title | Whole Blood Viscosity and Cerebral Blood Flow in Acute Ischemic Stroke |
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ERA Journal ID | 16856 |
Article Category | Article |
Authors | Gyawali, Prajwal, Lillicrap, Thomas P., Garcia-Esperon, Carlos G., Bhattarai, Aseem, Bivard, Andrew and Spratt, Neil |
Journal Title | Seminars in Thrombosis and Hemostasis |
Journal Citation | 50 (4), pp. 580-591 |
Number of Pages | 12 |
Year | 2024 |
Publisher | Georg Thieme |
Place of Publication | United States |
ISSN | 0094-6176 |
1098-9064 | |
Digital Object Identifier (DOI) | https://doi.org/10.1055/s-0043-1775858 |
Web Address (URL) | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1775858 |
Abstract | Existing effective treatments for ischemic stroke restore blood supply to the ischemic region using thrombolysis or mechanical removal of clot. However, it is increasingly recognized that successful removal of occlusive thrombus from the large artery-recanalization, may not always be accompanied by successful restoration of blood flow to the downstream tissues-reperfusion. Ultimately, brain tissue survival depends on cerebral perfusion, and a functioning microcirculation. Because capillary diameter is often equal to or smaller than an erythrocyte, microcirculation is largely dependent on erythrocyte rheological (hemorheological) factors such as whole blood viscosity (WBV). Several studies in the past have demonstrated elevated WBV in stroke compared with healthy controls. Also, elevated WBV has shown to be an independent risk factor for stroke. Elevated WBV leads to endothelial dysfunction, decreases nitric oxide-dependent flow-mediated vasodilation, and promotes hemostatic alterations/thrombosis, all leading to microcirculation sludging. Compromised microcirculation further leads to decreased cerebral perfusion. Hence, modulating WBV through pharmacological agents might be beneficial to improve cerebral perfusion in stroke. This review discusses the effect of elevated WBV on endothelial function, hemostatic alterations, and thrombosis leading to reduced cerebral perfusion in stroke. |
Keywords | acute ischemic stroke; whole blood viscosity; cerebral perfusion; microcirculation |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 320905. Neurology and neuromuscular diseases |
320102. Haematology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | School of Health and Medical Sciences |
Hunter Medical Research Institute, Australia | |
Institute of Medicine, Nepal | |
Royal Melbourne Hospital, Australia | |
University of Newcastle |
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