Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome
Article
Gyawali, Prajwal, Richards, Ross S., Bwititi, Phillip T. and Nwose, Ezekiel Uba. 2015. "Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome." Blood Cells, Molecules and Diseases. 54 (4), pp. 360-363. https://doi.org/10.1016/j.bcmd.2015.01.005
| Article Title | Association of abnormal erythrocyte morphology with oxidative stress and inflammation in metabolic syndrome |
|---|---|
| ERA Journal ID | 15798 |
| Article Category | Article |
| Authors | Gyawali, Prajwal, Richards, Ross S., Bwititi, Phillip T. and Nwose, Ezekiel Uba |
| Journal Title | Blood Cells, Molecules and Diseases |
| Journal Citation | 54 (4), pp. 360-363 |
| Number of Pages | 360-363 |
| Year | 2015 |
| Publisher | Elsevier |
| Place of Publication | United States |
| ISSN | 1079-9796 |
| 1096-0961 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.bcmd.2015.01.005 |
| Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S107997961500025X |
| Abstract | In carrying out their role of free radical scavenging, erythrocytes become damaged due to oxidation of membrane lipids and proteins. Such damage may change the morphology of the erythrocytes. The present study aims to demonstrate change in erythrocyte morphology in MetS and associate the changes with increased oxidative stress and inflammation that were shown in our recent study. One hundred participants were recruited from a rural town of Australia. Whole blood viscosity, erythrocyte aggregation, erythrocyte deformability, lipid profile and blood sugar level, oxidative stress markers (erythrocyte reduced glutathione, superoxide dismutase, urinary isoprostanes) and inflammatory markers (high sensitivity C-reactive protein) were measured. Erythrocyte morphological study was performed by scanning electron microscopy. Recruited participants were classified into MetS and non-MetS following the National Cholesterol Education Program Adult Treatment Panel III definition. Data were analyzed by IBM SPSS 20 software. The mean percentages of biconcave cells were decreased whereas acanthocytes, stomatocytes and echinocytes were increased in MetS group compared to healthy controls. Morphologically abnormal erythrocytes were significantly correlated with oxidative stress and chronic inflammation markers. Free radicals generated in increased concentration in MetS seem to damage erythrocyte changing its morphology which possibly could affect other hemorheological parameters. |
| Keywords | Erythrocyte morphology |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 420605. Preventative health care |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Charles Sturt University |
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