Whole blood viscosity assessment issues II: prevalence in endothelial dysfunction and hypercoagulation
Article
Nwose, Ezekiel Uba. 2010. "Whole blood viscosity assessment issues II: prevalence in endothelial dysfunction and hypercoagulation." North American Journal of Medical Sciences. 2 (6), pp. 252-257.
Article Title | Whole blood viscosity assessment issues II: prevalence in endothelial dysfunction and hypercoagulation |
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Article Category | Article |
Authors | Nwose, Ezekiel Uba |
Journal Title | North American Journal of Medical Sciences |
Journal Citation | 2 (6), pp. 252-257 |
Number of Pages | 6 |
Year | 2010 |
Publisher | Medknow Publications |
Place of Publication | India |
ISSN | 1947-2714 |
2250-1541 | |
Abstract | Background: Virchow’s triad in cardiovascular disease comprises blood viscosity, plasma D-dimer and homocysteine as indices of three associated but separate vascular phenomena. Aims: This work investigates prevalence of hyperviscosity in hyperhomocysteinaemia and positive D-dimer; and differences or similarities in stasis status among sub-populations of hyperhomocysteinaemia vs. normohomocysteinaemia and negative vs. positive D-dimer. Patients and Methods: 10-years de-identified archived clinical pathology data for the period of January 1999 to December 2008 were audited. All cases tested for D-dimer (n=6845) and homocysteine (n=1665), which were concomitantly tested for haematocrit and total proteins, were extracted. Results: The results show a very low prevalence of hyperviscosity associated with a positive D-dimer sub-population (1.48%), which is not statistically different in comparison with the negative D-dimer sub-population. The prevalence of hyperviscosity associated with hyperhomocysteinaemia (5.04%) was statistically significantly higher in comparison to the normohomocysteinaemia sub-population (p = 0.05). The prevalence of low viscosity is significantly higher in the positive D-dimer sub-population relative to the negative D-dimer sub-population (p < 0.00001), but not different between hyperhomocysteinaemia vs. normohomocysteinaemia. Normoviscosity is statistically significantly commoner in normo-relative to hyper-homocysteinaemia as well as in negative compared with positive D-dimer (p < 0.00001). Conclusion: The findings reported here suggest putting into perspective the specificity of whole blood viscosity relative to stasis, not necessarily sensitivity to disease conditions where it is implicated |
Keywords | whole blood viscosity; Cardiovascular complication; clinical laboratory evaluation; D-dimer; homocysteine; stasis; Virchow’s triad |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 420605. Preventative health care |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | South West Pathology Service, Australia |
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