Effects of zidovudine on auditory functions: enzymology and oxidative stress perspectives
Article
Igbigbi, PS, Adjene, JO and Nwose, Ezekiel. 2013. "Effects of zidovudine on auditory functions: enzymology and oxidative stress perspectives." Diagnostic and Therapeutic Study. 2 (4), pp. 76-82.
Article Title | Effects of zidovudine on auditory functions: enzymology and oxidative stress perspectives |
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Article Category | Article |
Authors | Igbigbi, PS, Adjene, JO and Nwose, Ezekiel |
Journal Title | Diagnostic and Therapeutic Study |
Journal Citation | 2 (4), pp. 76-82 |
Number of Pages | 7 |
Year | 2013 |
Publisher | ScopeMed International Medical Journal Managment and Indexing System |
ISSN | 2229-211X |
Abstract | The biochemical effects of chronic administration of Zidovudine (commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1) therapy on the intracranial auditory relay centres, namely the inferior colliculus and medial geniculate body, of adult Wister rats were studied. The objective is to investigate whether oxidative stress indicated by malondialdehyde and antioxidant enzymes is increased in the tissues of zidovudine treatment compared to non-treated group. The rats of both sexes (N=40), with an average weight of 200g were randomly assigned into treatment (n1=20) and control (n2=20) groups. The rats in the treatment group received 300mg/70kg (0.857mg/200g) body weight of AZT being the dosages required twice daily dissolved in distilled water daily and given for thirty days through orogastric tube administration While the control rats received equal volume of distilled water through the same route and for the same period. Catalase, G6PD, glutathione peroxidase, lactate dehydrogenase and SOD; as well as malondialdehyde were tested in the inferior colliculus and medial geniculate body tissues. At p<0.05, most antioxidant enzymes activities and oxidative stress levels are increased in the AZT-treated group. There is a confounding observation of MDA levels and SOD activities being significantly lower in the AZT-treated IC, but higher in MGB tissues compared to their control groups. Given that the tissues studied are the intracranial auditory relay tissues, it could be inferred that there is a potential of zidovudine to impair hearing function. Further studies are required to investigate whether laboratory evaluation of enzymes and oxidative stress tests could be useful in the determination and monitoring of hearing defects during zidovudine therapy. |
Keywords | auditory function |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 420605. Preventative health care |
Public Notes | There are no files associated with this item. |
Byline Affiliations | No affiliation |
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