Serum uric acid and albumin levels and estimated glomerular filtration rate: Oxidative stress considerations
Article
Bwititi, Phillip, Nwose, Uba, Nielsen, Sharon, Ruven, Henk, Kalle, Wouter, Richards, Ross and Butkowski, Eugene. 2012. "Serum uric acid and albumin levels and estimated glomerular filtration rate: Oxidative stress considerations." Australian Journal of Medical Science. 33 (3), pp. 82-87.
| Article Title | Serum uric acid and albumin levels and estimated glomerular filtration rate: Oxidative stress considerations |
|---|---|
| ERA Journal ID | 15768 |
| Article Category | Article |
| Authors | Bwititi, Phillip, Nwose, Uba, Nielsen, Sharon, Ruven, Henk, Kalle, Wouter, Richards, Ross and Butkowski, Eugene |
| Journal Title | Australian Journal of Medical Science |
| Journal Citation | 33 (3), pp. 82-87 |
| Number of Pages | 6 |
| Year | 2012 |
| Publisher | Australian Institute of Medical Scientists |
| Place of Publication | Australia |
| ISSN | 1038-1643 |
| Web Address (URL) | https://search.informit.org/doi/10.3316/INFORMIT.797536677532825 |
| Abstract | Uric acid has both antioxidant and oxidant properties, is excreted by the kidney and is associated with development of kidney disease. Albumin, another antioxidant is also excreted by the kidney in some renal diseases. The association and correlation of serum uric acid, albumin and estimated glomerular filtration rate (eGFR) could indicate the potential of renal function testing in evaluation of oxidative stress. This preliminary retrospective study looked at data on eGFR and serum levels of uric acid and albumin in 274 patients (120 males and 154 females) with an average age of 60.1 years but did not take into account any existing conditions or medication. Serum albumin levels were reduced as eGFR decreased and an inverse relationship between eGFR and serum uric acid levels with a statistically significant but weak partial correlation was also observed after accounting for sex and age (r = -0.32; p < 0.001). A controlled study on oxidant/anti-oxidant capacity of uric acid and other metabolites and relate these to renal function could be performed and this could lead to an indication of oxidative damage to the kidneys. |
| Keywords | uric acid; GFR; eGFR; albumin; oxidative stress; renal function |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 420305. Health and community services |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Charles Sturt University |
| Nepean Hospital Pathology, Australia | |
| St Antonius Hospital, Netherlands | |
| South West Pathology Service, Australia |
Permalink -
https://research.usq.edu.au/item/z1y85/serum-uric-acid-and-albumin-levels-and-estimated-glomerular-filtration-rate-oxidative-stress-considerations
4
total views0
total downloads1
views this month0
downloads this month