Atherothrombosis and oxidative stress: The connection and correlation in diabetes
Article
Nwose, Ezekiel U, Jelinek, Herbert F., Richards, Ross S., Tinley, Paul and Kerr, Philip G.. 2009. "Atherothrombosis and oxidative stress: The connection and correlation in diabetes." Redox Report. 14 (2), pp. 55-60. https://doi.org/10.1179/135100009X392458
| Article Title | Atherothrombosis and oxidative stress: The connection and correlation in diabetes |
|---|---|
| ERA Journal ID | 14858 |
| Article Category | Article |
| Authors | Nwose, Ezekiel U, Jelinek, Herbert F., Richards, Ross S., Tinley, Paul and Kerr, Philip G. |
| Journal Title | Redox Report |
| Journal Citation | 14 (2), pp. 55-60 |
| Number of Pages | 6 |
| Year | 2009 |
| Publisher | Taylor & Francis |
| Place of Publication | United Kingdom |
| ISSN | 1351-0002 |
| 1743-2928 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1179/135100009X392458 |
| Web Address (URL) | https://www.tandfonline.com/doi/abs/10.1179/135100009X392458 |
| Abstract | Background: Hyperglycaemia-induced depletion of reduced glutathione (GSH) causes erythrocyte oxidative stress (EOS), which leads to vascular events including exacerbation of thrombotic events evidenced by changes in D-dimer level. It would, therefore, appear that there is a complex link between GSH and D-dimer, which are part of an emerging array of biomarkers associated with diabetes. The objective of this study was to investigate evidence of correlation between levels of plasma D-dimer and erythrocyte GSH in diabetes disease progression. Subjects and methods: A cohort of 69 subjects were selected based on medical history plus clinical findings and equally divided into control, prediabetes and diabetes groups, matched for age and sex. Plasma D-dimer and erythrocyte reduced glutathione (GSH) were determined and separated into quartiles as a means of indicating disease severity. Statistical analysis was by Pearson's correlation coefficient. Results: Of the three groups, only the diabetes group showed any correlation between GSH and D-dimer. Of importance is that for increasing GSH, the second quartile range of GSH (xbar ± SD = 45 ± 22 mg/100ml) showed a statistically significant negative correlation for ranked D-dimer (xbar ± SD = 1055 ± 828 μg/l; r = −0.88; P < 0.02). The fourth quartile GSH range (xbar ± SD = 79 ± 40 mg/100 ml) showed a statistically significant positive correlation with D-dimer (xbar ± SD = 1055 ± 828 μg/l; r = 0.91; P < 0.02). Thus, within the diabetes group only, the increasing level of oxidative stress as measured by GSH first indicates a reduction in D-dimer followed by a rise in D-dimer, which led to the proposal of a two-part process of atherosclerosis that reconciles previous contradictory findings. Conclusions: This study provides not only evidence of a correlation between oxidative stress level and fibrinolysis in diabetes, but also an explanation of why previous studies have found both hypo- or hyperfibrinolysis associated with diabetes. |
| Keywords | atherothrombogenesis; diabetes; D-dimer; erythrocyte oxidative stress; reduced glutathione |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 420605. Preventative health care |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Charles Sturt University |
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