The ‘vitamin E regeneration system’ (VERS) and an algorithm to justify antioxidant supplementation in diabetes – A hypothesis
Article
Nwose, Ezekiel U., Jelinek, Herbert F., Richards, Ross S. and Kerr, Philip G.. 2008. "The ‘vitamin E regeneration system’ (VERS) and an algorithm to justify antioxidant supplementation in diabetes – A hypothesis
." Medical Hypotheses. 70 (5), pp. 1002-1008. https://doi.org/10.1016/j.mehy.2007.07.048
| Article Title | The ‘vitamin E regeneration system’ (VERS) and an algorithm to justify antioxidant supplementation in diabetes – A hypothesis |
|---|---|
| ERA Journal ID | 15322 |
| Article Category | Article |
| Authors | Nwose, Ezekiel U., Jelinek, Herbert F., Richards, Ross S. and Kerr, Philip G. |
| Journal Title | Medical Hypotheses |
| Journal Citation | 70 (5), pp. 1002-1008 |
| Number of Pages | 7 |
| Year | 2008 |
| Publisher | Elsevier |
| Place of Publication | United Kingdom |
| ISSN | 0306-9877 |
| 1532-2777 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mehy.2007.07.048 |
| Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/S0306987707005658 |
| Abstract | In studies of vitamin E effectiveness in diabetes, there are still controversies surrounding negative observational and positive experimental results. However, there is no controversy that antioxidant vitamin E is regenerated from its pro-oxidant tocopheroxyl radical by a network of interacting co-antioxidants. The network of interacting co-antioxidants has only been studied individually. The hypothesis we propose is that a vitamin E regeneration system (VERS) model based on the complex interactions of the co-antioxidants provides a rationale for vitamin E supplementation as a therapeutic adjunct in diabetes. Furthermore, the factors considered prior to the use of Vitamin E as a supplement in diabetes research and therapy, the effectiveness of vitamin E supplementation and the limitations have been identified in the literature. There is no single study of vitamin E supplementation or efficacy that has determined vitamin E levels in combination with all of the co-antioxidants that interact to regenerate oxidised vitamin E. Therefore, there is a lack of good evidence for or against vitamin E being unilaterally depleted in the antioxidant network. There is also lack of rationale for choice of co-antioxidant supplementation. In essence, the normal conditions for effective antioxidant activity of vitamin E supplementation have yet to be fully explored. We propose a coherent model of VERS, and recommend that VERS status needs to be assessed, as part of evidence-based clinical practice to determine whether vitamin E should be recommended for the diabetic patient. We also propose an algorithm, based on the antioxidant activity and confounding factors, to guide the formulation of a credible hypothesis for clinical trials in assessing the function of vitamin E and treatment outcomes. The proposed model hinges on pertinent questions that have to be addressed to avoid organising a clinical trial that has been identified as biased. |
| Keywords | Algorithms |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 420605. Preventative health care |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Charles Sturt University |
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