Histological effects of chronic administration of aqueous extract of Phyllanthus amarus on the stomach and the duodenum of Wistar rat
Article
Article Title | Histological effects of chronic administration of aqueous extract of Phyllanthus amarus on the stomach and the duodenum of Wistar rat |
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Article Category | Article |
Authors | Adjene, J.O., Abudu, I.E. and Nwose, E.U. |
Journal Title | Electronic Journal of Biomedicine |
Journal Citation | 2011 (1), pp. 9-13 |
Number of Pages | 9-13 |
Year | 2011 |
Publisher | Asociacion Red Uninet |
Place of Publication | Spain |
ISSN | 1697-090X |
Web Address (URL) | https://biomed.uninet.edu/2011/n1/adjene.html |
Abstract | Background: Phyllanthus amarus is a herbal agent commonly used for the treatment of several diseases including gastric ones. A systematic study about its toxic effects when chronically and excessively administered is still lacking. Aim: This study investigates the histological effects of chronic administration of the herb on the stomach and the duodenum of adult Wistar rats of both sexes. Material and methods: Rats, with average weight of 200g, were divided into three groups of eight animals each: A (P amarus at a single dose of 400mg/kg body weight daily for thirty days through an orogastric tube); B (P. amarus at a single dose of 800mg/kg body weight daily through the same route and period), and C (controls, receiving equal volume of distilled water in identical conditions to A and B). Rats were fed with grower's mash and received water ad libitum. Animals were euthanized by cervical dislocation on the thirty-one day of the experiment and the stomach and the duodenum were immediately dissected out and fixed in 10% formaldehyde- saline for routine histological techniques. Results: Rats in the treated groups showed some distortions in the epithelial cells of the stomach and the duodenum and signs of inflammation, when compared with controls. Conclusion: This report provides evidence that ethnomedicinal practice involving chronic administration of Phyllanthus amarus at high doses has potential adverse histological effect in determined digestive organs. It is likely that the herb may be contraindicated in gastro-ulcer patients. This warrants further studies to establish or rule out any untoward side-effect on bowel response and/or digestive dysfunctions. |
Keywords | Antioxidant toxicity; digestive tract; ethnomedicinal practice; histological effects; Phyllanthus amarus |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 420305. Health and community services |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions, but may be accessed online. Please see the link in the URL field. |
Byline Affiliations | University of Benin, Nigeria |
South West Pathology Service, Australia |
https://research.usq.edu.au/item/z1y8v/histological-effects-of-chronic-administration-of-aqueous-extract-of-phyllanthus-amarus-on-the-stomach-and-the-duodenum-of-wistar-rat
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