Photosensitization of the sunscreen octyl-p-dimethylaminobenzoate by UVA in human melanocytes but not in keratinocytes
Article
Article Title | Photosensitization of the sunscreen octyl-p-dimethylaminobenzoate by UVA in human melanocytes but not in keratinocytes |
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ERA Journal ID | 15283 |
Article Category | Article |
Authors | Xu, Chunxia (Author), Green, Adele (Author), Parisi, Alfio (Author) and Parsons, Peter G. (Author) |
Journal Title | Photochemistry and Photobiology |
Journal Citation | 73 (6), pp. 600-604 |
Number of Pages | 5 |
Year | 2001 |
Publisher | John Wiley & Sons |
Place of Publication | United States |
ISSN | 0031-8655 |
1751-1097 | |
Digital Object Identifier (DOI) | https://doi.org/10.1562/0031-8655(2001)0730600POTSOP2.0.CO2 |
Web Address (URL) | https://bioone.org/journals/photochemistry-and-photobiology/volume-73/issue-6/0031-8655_2001_073_0600_POTSOP_2.0.CO_2/Photosensitization-of-the-Sunscreen-Octyl-p-Dimethylaminobenzoate-by-UVA-in/10.1562/0031-8655(2001)073%3C0600:POTSOP%3E2.0.CO;2.short |
Abstract | Sunscreens penetrate human epidermis and modify the biology of proliferating cells. This study addressed the question whether the UV response of cultured human cells is affected by direct treatment with nontoxic levels of sunscreens. Cell survival following exposure to UVC or unfiltered UVB was not altered by preincubation with 25 mg/mL of octyl p-dimethylaminobenzoate (o-PABA), 2-ethylhexyl p-methoxycinnamate (EHMC) or oxybenzone. However, UVA or UVB filtered to reproduce the solar UV spectrum penetrating to the basal layer of the epidermis, highly sensitized cells to killing by o-PABA but not by its hydrolysis product, 4-dimethylaminobenzoic acid. Sensitization was found in all cell types tested, except normal keratinocytes, and could be prevented by certain antioxidants particularly pyruvate and the hydroxyl radical scavenger mannitol. o-PABA and EHMC |
Keywords | sunscreen; skin; skin cancer; cell biology; UVA: UVC; UVB; antioxidant; prevention |
ANZSRC Field of Research 2020 | 320801. Cell physiology |
310105. Cellular interactions (incl. adhesion, matrix, cell wall) | |
370106. Atmospheric radiation | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland Institute of Medical Research, Australia |
Department of Biological and Physical Sciences | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q062z/photosensitization-of-the-sunscreen-octyl-p-dimethylaminobenzoate-by-uva-in-human-melanocytes-but-not-in-keratinocytes
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