Surface coating of poly-D-L-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement
Paper
Paper/Presentation Title | Surface coating of poly-D-L-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement |
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Presentation Type | Paper |
Authors | Chen, Ling (Author), Tang, Chak Yin (Author), Ku, Harry Siu Lung (Author), Chen, Da Zhu (Author) and Tsui, Chi Pong (Author) |
Editors | Bose, Susmita, Narayan, Roger and Bandyopadhyay , Amit |
Journal or Proceedings Title | Materials Science and Technology Conference (MS&T 2012) |
ERA Conference ID | 60655 |
Number of Pages | 8 |
Year | 2013 |
Place of Publication | Hoboken, NJ. United States |
ISBN | 9781118751039 |
9781118751015 | |
Digital Object Identifier (DOI) | https://doi.org/10.1002/9781118751015 |
Conference/Event | Materials Science and Technology Conference (MS&T 2012): Next Generation Biomaterials and Surface Properties of Biomaterials |
Materials Science and Technology Conference | |
Event Details | Materials Science and Technology Conference (MS&T 2012): Next Generation Biomaterials and Surface Properties of Biomaterials Event Date 27 to end of 31 Oct 2012 Event Location Pittsburgh, United States |
Event Details | Materials Science and Technology Conference |
Abstract | Biodegradable polymeric nano-composite scaffolds have recently attracted considerable attention in curing bone deficiencies resulting from fractures or traumas. In this article, the latest progress in fabrication and characterization of poly-D-L-lactide/nano-hydroxyapatite (PDLLA/nano-HA) composite scaffolds, with poly (ethylene glycol) (PEG)-coating and dexamethasone (Dex)-releasing for bone tissue engineering is presented. For the design of drug release scaffolds, some aspects related to the choice of polymer matrix, bioactive inclusions, drug release coatings, and fabrication techniques are firstly reviewed. A PEG-based coating method was subsequently developed to modify a biodegradable polymeric nano-composite scaffold in providing a drug release function with improved wettability. The changes of water contact angle of the scaffolds before and after PEG/Dex coating were measured and the drug release function of the PEG/Dex coating was studied. The experimental findings showed that the proposed coating method was effective in enhancing the wettability and in controlling the early stage of drug release of the PDLLA/nano-HA composite scaffold. |
Keywords | bone tissue engineering; coating methods; composite scaffolds; Dexamethasones; fabrication and characterizations; fabrication technique; surface coatings; water contact angle |
ANZSRC Field of Research 2020 | 310607. Nanobiotechnology |
401602. Composite and hybrid materials | |
400302. Biomaterials | |
Public Notes | Copyright © 2013 by The American Ceramic Society. All rights reserved. Series: Ceramic Transactions, vol. 242. Electronic copy held USQ Library. |
Byline Affiliations | Hong Kong Polytechnic University, China |
Centre of Excellence in Engineered Fibre Composites | |
Shenzhen University, China | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q217v/surface-coating-of-poly-d-l-lactide-nano-hydroxyapatite-composite-scaffolds-for-dexamethasone-releasing-function-and-wettability-enhancement
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