Perspectives of Healthcare Professionals Towards Combination Use of Oral Paracetamol and Topical Non-Steroidal Inflammatory Drugs in Managing Mild-to-Moderate Pain for Osteoarthritis in a Clinical Setting: An Exploratory Study

Article


Sethi, Vidhu, Van der Laan, Luke, Gupta, Sanjeev and Piros, K. Cornelius. 2022. "Perspectives of Healthcare Professionals Towards Combination Use of Oral Paracetamol and Topical Non-Steroidal Inflammatory Drugs in Managing Mild-to-Moderate Pain for Osteoarthritis in a Clinical Setting: An Exploratory Study." Journal of Pain Research. 15, pp. 2263-2272. https://doi.org/10.2147/JPR.S373382
Article Title

Perspectives of Healthcare Professionals Towards Combination Use of Oral Paracetamol and Topical Non-Steroidal Inflammatory Drugs in Managing Mild-to-Moderate Pain for Osteoarthritis in a Clinical Setting: An Exploratory Study

ERA Journal ID123863
Article CategoryArticle
AuthorsSethi, Vidhu (Author), Van der Laan, Luke (Author), Gupta, Sanjeev (Author) and Piros, K. Cornelius (Author)
Journal TitleJournal of Pain Research
Journal Citation15, pp. 2263-2272
Number of Pages10
Year2022
Place of PublicationUnited Kingdom
ISSN1178-7090
Digital Object Identifier (DOI)https://doi.org/10.2147/JPR.S373382
Web Address (URL)https://www.dovepress.com/perspectives-of-healthcare-professionals-towards-combination-use-of-or-peer-reviewed-fulltext-article-JPR
Abstract

Purpose: To seek indicative evidence on clinical prescription practice and perspectives regarding combined oral paracetamol (APAP) and/or topical non-steroidal anti-inflammatory drugs (NSAIDs) therapy for managing mild-to-moderate osteoarthritis (OA) pain. Participants and Methods: An exploratory qualitative study to investigate the perspectives towards using APAP and/or topical NSAIDs for OA pain management and whether current clinical practices are aligned with OA guidelines was conducted using a two-round modified Delphi methodology among three general practitioners, three orthopedists, and two pharmacists from Australia, Malaysia, and Sweden during January–June 2021. In the first round, 60-minute virtual in-depth interviews were conducted individually; in the second round, summary of the key findings was shared with the panel to seek clarity on the level of consensus (≥70% unanimity) and disagreement. Results: The healthcare professionals (HCPs) agreed that APAP was considered as a universally accepted pharmacologic for most OA patients except those with contraindications or allergies. Consensus was achieved towards APAP combination with topical NSAIDs being a safer alternative than with oral NSAIDs. However, prescription uptake of combined therapy APAP with topical NSAIDs was low among the panel due to lack of strong scientific evidence on efficacy and awareness. Differences in clinical practice across and within countries could be due to different reference sources for OA pain – clinical practice experience or local/international guidelines/ medical products handbooks. Conclusion: The study suggests an opportunity to raise awareness of the suitability and potential benefits for adjuvant topical NSAIDs to APAP for effective OA pain management as well as a need for universal OA guidelines.

Keywordscombination therapy, pain relief, Delphi methodology, consensus, prescription uptake
Related Output
Is part ofInvestigating the use of oral paracetamol and topical non-steroidal anti-inflammatory drug (NSAID) - diclofenac as a combination therapy for mild to moderate osteoarthritis (OA) pain: an evidence-based assessment using data mining and the application of machine learning (ML)
ANZSRC Field of Research 2020321403. Clinical pharmacy and pharmacy practice
441006. Sociological methodology and research methods
Public Notes

This article is part of a UniSQ Thesis by publication. See Related Output.

Byline AffiliationsGlaxoSmithKline Consumer Healthcare, Singapore
School of Education
Department of Health, New South Wales
Regena Healthcare, Malaysia
Institution of OriginUniversity of Southern Queensland
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