Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers
Article
Article Title | Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers |
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ERA Journal ID | 14856 |
Article Category | Article |
Authors | Su, Bobo (Author), Wang, Sha (Author), Sumich, Alexander (Author), Li, Shaomei (Author), Yang, Ling (Author), Cai, Yueyue (Author) and Wang, Grace Y. (Author) |
Journal Title | Psychopharmacology |
Journal Citation | 234 (21), pp. 3195-3205 |
Number of Pages | 11 |
Year | 2017 |
Publisher | Springer |
Place of Publication | Germany |
ISSN | 0033-3158 |
1432-2072 | |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00213-017-4707-5 |
Web Address (URL) | https://link.springer.com/article/10.1007/s00213-017-4707-5 |
Abstract | Rationale: Chronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to drug-related cues may exist following abstinence from heroin use. Objectives: The present study aimed to examine the effect of drug-related cues on response inhibition in long-term heroin abstainers. Methods: Sixteen long-term (8–24 months) male heroin abstainers and 16 male healthy controls completed a modified two-choice oddball paradigm, in which a neutral “chair” picture served as frequent standard stimuli; the neutral and drug-related pictures served as infrequent deviant stimuli of different conditions respectively. Event-related potentials were compared across groups and conditions. Results: Our results showed that heroin abstainers exhibited smaller N2d amplitude (deviant minus standard) in the drug cue condition compared to the neutral condition, due to smaller drug-cue deviant-N2 amplitude compared to neutral deviant-N2. Moreover, heroin abstainers had smaller N2d amplitude compared with the healthy controls in the drug cue condition, due to the heroin abstainers having reduced deviant-N2 amplitude compared to standard-N2 in the drug cue condition, which reversed in the healthy controls. Conclusions: Our findings suggested that heroin addicts still show response inhibition deficits specifically for drug-related cues after longer-term abstinence. The inhibition-related N2 modulation for drug-related could be used as a novel electrophysiological index with clinical implications for assessing the risk of relapse and treatment outcome for heroin users. |
Keywords | Drug-related cues; Event-related potentials; Heroin abstainers; Response inhibition; Two-choice oddball task |
ANZSRC Field of Research 2020 | 520205. Psychopharmacology |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Northwest Normal University, China |
Nottingham Trent University, United Kingdom | |
Auckland University of Technology, New Zealand | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q7508/reduction-in-n2-amplitude-in-response-to-deviant-drug-related-stimuli-during-a-two-choice-oddball-task-in-long-term-heroin-abstainers
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