Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers
Article
Article Title | Effect of drug-related cues on response inhibition through abstinence: A pilot study in male heroin abstainers |
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ERA Journal ID | 6077 |
Article Category | Article |
Authors | Su, Bobo (Author), Yang, Ling (Author), Wang, Grace Y. (Author), Wang, Sha (Author), Li, Shaomei (Author), Cao, Hua (Author) and Zhang, Yan (Author) |
Journal Title | American Journal of Drug and Alcohol Abuse |
Journal Citation | 43 (6), pp. 664-670 |
Number of Pages | 7 |
Year | 2017 |
Place of Publication | United States |
ISSN | 0095-2990 |
1097-9891 | |
Digital Object Identifier (DOI) | https://doi.org/10.1080/00952990.2017.1283695 |
Web Address (URL) | https://www.tandfonline.com/doi/full/10.1080/00952990.2017.1283695 |
Abstract | Background: Chronic heroin use can cause a deficit of inhibitory function, leading to a loss of control over drug use. Exposure to drug-related cues is considered as one of the contributing factors. However, it is unclear whether there are dynamic changes on the effect of drug-related cues on response inhibition following prolonged abstinence. Objective: The present study investigated the effect of drug-related cues on response inhibition in heroin abstainers at different abstinent phases. Methods: 26 shorter-term (2–6 months) and 26 longer-term (19–24 months) male heroin abstainers performed on a modified two-choice Oddball task, which included two conditions: in the cued condition, neutral pictures served as the background of standard stimuli (yellow frame) and heroin-related pictures served as the background of deviant stimuli (blue frame), reversed in the controlled conditions. Results: Compared to longer-term abstainers, mean reaction time (RT) for drug deviants in shorter-term abstainers was significantly longer. Shorter-term abstainers also showed markedly slower response to neutral deviants relative to drug deviants, but this tendency was not observed in longer-term abstainers. Nevertheless, both groups had similar RT for standard stimuli regardless of their paired background pictures. Conclusion: Effect of drug-related cues on response inhibition remains at the early stage of abstinence; however, this effect may be reduced following a longer period of drug abstinence. Our findings highlight the importance of assessing and improving the ability of inhibiting drug-related cue reactivity during treatment. |
Keywords | drug-related cues; Heroin abstainers; response inhibition; two-choice Oddball task |
ANZSRC Field of Research 2020 | 520203. Cognitive neuroscience |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Northwest Normal University, China |
Auckland University of Technology, New Zealand | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q750q/effect-of-drug-related-cues-on-response-inhibition-through-abstinence-a-pilot-study-in-male-heroin-abstainers
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