The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans

Article

Denham, Joshua. 2019. "The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans." Biomedical journal. 42 (6), pp. 430-433. https://doi.org/10.1016/j.bj.2019.07.003
Article Title

The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans

Article CategoryArticle
Authors
AuthorDenham, Joshua
Journal TitleBiomedical journal
Journal Citation42 (6), pp. 430-433
Number of Pages4
Year2019
Place of PublicationNetherlands
Digital Object Identifier (DOI)https://doi.org/10.1016/j.bj.2019.07.003
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S2319417019304743
Abstract

Telomeres protect genomic integrity and shorten in somatic cells due to the end replication problem. Sperm telomeres are, however, longer in older individuals and linked to semen quality. Exercise training may attenuate age-related telomere shortening in somatic cells, but the influence of exercise on sperm telomeres is unknown. Mature sperm from 34 healthy men were isolated by density gradient centrifugation and telomere length was assessed by qPCR. No significant correlations were observed between telomere length, fitness or exercise performance. Inter-individual variation in sperm telomere length responses to a 6-wk vigorous exercise training intervention (ΔT/S ratio range: -0.49 to 0.87) and a strong correlation between improvements in fitness and sperm telomere lengthening were revealed (r = 0.87, p < 0.001). These preliminary data suggest exercise training may regulate sperm telomere length and should encourage larger studies to explore the implications this may have on the health of the next generation.

KeywordsBiological ageing; Cardiorespiratory fitness; HIIT; Spermatozoa
ANZSRC Field of Research 2020310599. Genetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsUniversity of New England
Institution of OriginUniversity of Southern Queensland
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