The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans
Article
Article Title | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
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Article Category | Article |
Authors | |
Author | Denham, Joshua |
Journal Title | Biomedical journal |
Journal Citation | 42 (6), pp. 430-433 |
Number of Pages | 4 |
Year | 2019 |
Place of Publication | Netherlands |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.bj.2019.07.003 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S2319417019304743 |
Abstract | Telomeres protect genomic integrity and shorten in somatic cells due to the end replication problem. Sperm telomeres are, however, longer in older individuals and linked to semen quality. Exercise training may attenuate age-related telomere shortening in somatic cells, but the influence of exercise on sperm telomeres is unknown. Mature sperm from 34 healthy men were isolated by density gradient centrifugation and telomere length was assessed by qPCR. No significant correlations were observed between telomere length, fitness or exercise performance. Inter-individual variation in sperm telomere length responses to a 6-wk vigorous exercise training intervention (ΔT/S ratio range: -0.49 to 0.87) and a strong correlation between improvements in fitness and sperm telomere lengthening were revealed (r = 0.87, p < 0.001). These preliminary data suggest exercise training may regulate sperm telomere length and should encourage larger studies to explore the implications this may have on the health of the next generation. |
Keywords | Biological ageing; Cardiorespiratory fitness; HIIT; Spermatozoa |
ANZSRC Field of Research 2020 | 310599. Genetics not elsewhere classified |
420702. Exercise physiology | |
Byline Affiliations | University of New England |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6q56/the-association-between-sperm-telomere-length-cardiorespiratory-fitness-and-exercise-training-in-humans
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