Lack of association between PBMC telomere length and endurance exercise

Article


Denham, Joshua. 2017. "Lack of association between PBMC telomere length and endurance exercise." Journal of Applied Biomedicine. 15 (1), pp. 9-13. https://doi.org/10.1016/j.jab.2016.09.004
Article Title

Lack of association between PBMC telomere length and endurance
exercise

ERA Journal ID123265
Article CategoryArticle
Authors
AuthorDenham, Joshua
Journal TitleJournal of Applied Biomedicine
Journal Citation15 (1), pp. 9-13
Number of Pages5
Year2017
Place of PublicationNetherlands
ISSN1214-021X
1214-0287
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jab.2016.09.004
Web Address (URL)https://jab.zsf.jcu.cz/artkey/jab-201701-0002_lack-of-association-between-pbmc-telomere-length-and-endurance-exercise.php
Abstract

Telomeres are repetitive DNA located at the ends of chromosomes that preserve genomic stability. Excessive leukocyte telomere shortening is associated with cardio-metabolic disease and increased mortality risk. Although most studies indicate exercise training could attenuate leukocyte telomere attrition, data is somewhat equivocal. The inconsistencies could be partly explained by the different populations of leukocytes isolated for telomere length assessment. Accordingly, average peripheral blood mononuclear cell (PBMC) and whole blood leukocyte telomere length were assessed in 44 endurance athletes and 40 healthy controls using quantitative PCR. While whole blood leukocyte telomeres were, on average, 6.1% longer in endurance athletes compared to controls, PBMC telomere length was similar between the two cohorts in age and sex-adjusted analyses (athletes vs controls, mean T/S ratio ± SE: 3.25 ± 0.05 vs 3.23 ± 0.05, p = 0.72). Other than a weak inverse correlation with sitting (r = −0.25, p = 0.03), no statistically significant correlations were found between PBMC telomere length and exercise parameters. Unlike whole blood leukocytes, PBMC telomere length is not associated with endurance exercise and exercise parameters. These findings suggest the need for future work to quantify short and long telomeres of sorted immune cell populations and to measure them in context with cell counts and exercise traits.

KeywordsAgeing; Biological age; Exercise; Leukocytes; Peripheral blood mononuclear cell
ANZSRC Field of Research 2020310599. Genetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsUniversity of New England
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q6q63/lack-of-association-between-pbmc-telomere-length-and-endurance-exercise

  • 64
    total views
  • 4
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Exercise training reduces arterial stiffness in women with high blood pressure: a systematic review and meta-analysis
Zaman, Shadman, Selva Raj, Isaac, Yang, Angela Wei Hong, Lindner, Robert and Denham, Joshua. 2024. "Exercise training reduces arterial stiffness in women with high blood pressure: a systematic review and meta-analysis." Journal of Hypertension. 42 (2), pp. 197-204. https://doi.org/10.1097/HJH.0000000000003594
Coconut Water: A Sports Drink Alternative?
O'Brien, Brendan J., Bell, Leo R., Hennessy, Declan, Denham, Joshua and Paton, Carl D.. 2023. "Coconut Water: A Sports Drink Alternative?" Sports. 11 (9). https://doi.org/10.3390/sports11090183
The Emerging Role of Hypoxic Training for the Equine Athlete
Davie, Allan, Beavers, Rosalind, Hargitaiová, Kristýna and Denham, Joshua. 2023. "The Emerging Role of Hypoxic Training for the Equine Athlete." Animals. 13 (17). https://doi.org/10.3390/ani13172799
A student-run exercise physiology clinic in Australia: who and what do we see?
Hume, E., Cameron, M., Findley, I., Smart, S., Elisaia, C., Hulme, A., Mills, D. and Denham, J.. 2023. "A student-run exercise physiology clinic in Australia: who and what do we see? " 2023 ASICS SMA Conference (ASICS SMA 2023). Sunshine Coast, Australia 11 - 14 Oct 2023 Australia. Elsevier. https://doi.org/10.1016/j.jsams.2023.08.107
Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis
Lindner, Robert, Selva Raj, Isaac, Yang, Angela Wei Hong, Zaman, Shadman, Larsen, Brianna and Denham, Joshua. 2023. "Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis." International Journal of Sports Medicine. 44 (7), pp. 484-495. https://doi.org/10.1055/a-2044-8952
Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training
Denham, Josh. 2023. "Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training." Aging Cell. 22 (6). https://doi.org/10.1111/acel.13836
Exercise regulates shelterin genes and microRNAs implicated in ageing in Thoroughbred horses
Mandal, Shama, Denham, Michele M., Spencer, Sarah J. and Denham, Joshua. 2022. "Exercise regulates shelterin genes and microRNAs implicated in ageing in Thoroughbred horses." Pfugers Archiv: European journal of physiology. 474 (11), p. 1159–1169. https://doi.org/10.1007/s00424-022-02745-0
Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training
Denham, Joshua, O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training." Sports Medicine. 46 (9), pp. 1213-1237. https://doi.org/10.1007/s40279-016-0482-4
Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness
Denham, Joshua and Prestes, Priscilla R.. 2016. "Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness." Frontiers in Genetics. 7, pp. 1-8. https://doi.org/10.3389/fgene.2016.00196
Epigenetic changes in leukocytes after 8 weeks of resistance exercise training
Denham, Joshua, Marques, Francine Z., Bruns, Emma L., O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Epigenetic changes in leukocytes after 8 weeks of resistance exercise training." European Journal of Applied Physiology. 116 (6), pp. 1245-1253. https://doi.org/10.1007/s00421-016-3382-2
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres
Denham, Joshua, O'Brien, Brendan J., Prestes, Priscilla R., Brown, Nicholas J. and Charchar, Fadi J.. 2016. "Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres." Journal of Applied Physiology. 120 (2), pp. 148-158. https://doi.org/10.1152/japplphysiol.00587.2015
Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness
Denham, Joshua, Brown, Nicholas J., Tomaszewski, Maciej, Williams, Bryan, O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness." European Journal of Applied Physiology. 116 (8), pp. 1537-1544. https://doi.org/10.1007/s00421-016-3407-x
Exercise and epigenetic inheritance of disease risk
Denham, Joshua. 2018. "Exercise and epigenetic inheritance of disease risk." Acta Physiologica. 222 (1), pp. 1-20. https://doi.org/10.1111/apha.12881
Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development
Denham, Joshua, Gray, Adrian, Scott-Hamilton, John and Hagstrom, Amanda D.. 2018. "Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development." International Journal of Sports Medicine. 39 (1), pp. 67-72. https://doi.org/10.1055/s-0043-120763
Time-restricted feeding influences immune responses without compromising muscle performance in older men
Gasmi, Maha, Sellami, Maha, Denham, Joshua, Padulo, Johnny, Kuvacic, Goran, Selmi, Walid and Khalifa, Riadh. 2018. "Time-restricted feeding influences immune responses without compromising muscle performance in older men." Nutrition. 51-52, pp. 20-37. https://doi.org/10.1016/j.nut.2017.12.014
microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors
Hagstrom, Amanda D. and Denham, Joshua. 2018. "microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors." International Journal of Sports Medicine. 39 (6), pp. 482-489. https://doi.org/10.1055/a-0592-7691
Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?
Sellami, Maha, Gasmi, Maha, Denham, Joshua, Hayes, Lawrence D., Stratton, Dan, Padulo, Johnny and Bragazzi, Nicola. 2018. "Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?" Frontiers in Immunology. 9, pp. 1-17. https://doi.org/10.3389/fimmu.2018.02187
The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer
Hagstrom, Amanda D. and Denham, Joshua. 2018. "The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer." Journal of Functional Morphology and Kinesiology. 3 (1), pp. 1-7. https://doi.org/10.3390/jfmk3010009
Small non-coding RNAs are altered by short-term sprint interval training in men
Denham, Joshua, Gray, Adrian J., Scott-Hamilton, John, Hagstrom, Amanda D. and Murphy, Aron J.. 2018. "Small non-coding RNAs are altered by short-term sprint interval training in men." Physiological Reports. 6 (7), pp. 1-10. https://doi.org/10.14814/phy2.13653
Leukocyte telomere length in the Thoroughbred racehorse
Denham, Josh and Denham, Michele M.. 2018. "Leukocyte telomere length in the Thoroughbred racehorse." Animal Genetics. 49 (5), pp. 452-456. https://doi.org/10.1111/age.12681
Age-associated telomere shortening in Thoroughbred horses
Denham, Joshua, Stevenson, Kim and Denham, Michele M.. 2019. "Age-associated telomere shortening in Thoroughbred horses." Experimental Gerontology. 127, pp. 1-3. https://doi.org/10.1016/j.exger.2019.110718
The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans
Denham, Joshua. 2019. "The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans." Biomedical journal. 42 (6), pp. 430-433. https://doi.org/10.1016/j.bj.2019.07.003
Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan
Hiam, Danielle, Smith, Cassandra, Voisin, Sarah, Denham, Josh, Yan, Xu, Landen, Shanie, Jacques, Macsue, Alvarez-Romero, Javier, Garnham, Andrew, Woessner, Mary N., Herrmann, Markus, Duque, Gustavo, Levinger, Itamar and Eynon, Nir. 2020. "Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan." Aging. 12 (1), pp. 359-369. https://doi.org/10.18632/aging.102627
Telomere regulation: lessons learnt from mice and men, potential opportunities in horses
Denham, Josh. 2020. "Telomere regulation: lessons learnt from mice and men, potential opportunities in horses." Animal Genetics. 51 (1), pp. 3-13. https://doi.org/10.1111/age.12870
Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations
Denham, Josh and Spencer, Sarah J.. 2020. "Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations." American Journal of Physiology: Endocrinology and Metabolism. 319 (2), pp. E320-E329. https://doi.org/10.1152/ajpendo.00215.2020
A Systematic Review and Meta-analysis on Sodium Bicarbonate Administration and Equine Running Performance: Is it Time to Stop Horsing Around With Baking Soda?
Denham, Joshua and Hulme, Adam. 2020. "A Systematic Review and Meta-analysis on Sodium Bicarbonate Administration and Equine Running Performance: Is it Time to Stop Horsing Around With Baking Soda?" Journal of Equine Veterinary Science. 95, pp. 1-7. https://doi.org/10.1016/j.jevs.2020.103281
Cycling power outputs predict functional threshold power and maximum oxygen uptake
Denham, Joshua, Scott-Hamilton, John, Hagstrom, Amanda D. and Gray, Adrian J.. 2021. "Cycling power outputs predict functional threshold power and maximum oxygen uptake." Journal of Strength and Conditioning Research. 34 (12), pp. 3489-3497. https://doi.org/10.1519/jsc.0000000000002253
Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a lifetime
Sellami, Maha, Bragazzi, Nicola, Prince, Mohammad Shoaib, Denham, Joshua and Elrayess, Mohamed. 2021. "Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a lifetime." Frontiers in Genetics. 12, pp. 1-12. https://doi.org/10.3389/fgene.2021.652497
Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
Nakai, Michael E., Denham, Joshua, Prestes, Priscilla R., Eikelis, Nina, Lambert, Elizabeth A., Straznicky, Nora E., Schlaich, Markus P., Esler, Murray D., O'Brien, Brendan J., Charchar, Fadi J., Lambert, Gavin W. and Marques, Francine Z.. 2021. "Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting." Scientific Reports. 11 (1), pp. 1-12. https://doi.org/10.1038/s41598-021-83472-x
Epigenetic control of exercise adaptations in the equine athlete: current evidence and future directions
Denham, Joshua, McCluskey, Michael, Denham, Michele M., Sellami, Maha and Davie, Alan J.. 2021. "Epigenetic control of exercise adaptations in the equine athlete: current evidence and future directions." Equine Veterinary Journal. 53 (3), pp. 431-450. https://doi.org/10.1111/evj.13320
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis
Denham, Joshua and Sellami, Maha. 2021. "Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis." Ageing Research Reviews. 70. https://doi.org/10.1016/j.arr.2021.101411
Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training
Dev, Prasun Kumar, Gray, Adrian J., Scott-Hamilton, John, Hagstrom, Amanda D., Murphy, Aron and Denham, Joshua. 2021. "Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training." Mechanisms of Ageing and Development. 199. https://doi.org/10.1016/j.mad.2021.111552
Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise
Denham, Joshua, O'Brien, Brendan J., Marques, Francine Z. and Charchar, Fadi J.. 2015. "Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise." Journal of Applied Physiology. 118 (4), pp. 475-488. https://doi.org/10.1152/japplphysiol.00878.2014
Four weeks of sprint interval training improves 5-km run performance
Denham, Joshua, Feros, Simon A and O'Brien, Brendan J.. 2015. "Four weeks of sprint interval training improves 5-km run performance." Journal of Strength and Conditioning Research. 29 (8), pp. 2137-2141. https://doi.org/10.1519/JSC.0000000000000862
Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans
Denham, Josh, O'Brien, Brendan J, Harvey, Jack T and Charchar, Fadi J. 2015. "Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans." Epigenomics. 7 (5). https://doi.org/10.2217/epi.15.29
Exercise: putting action into our epigenome
Denham, Josh, Marques, Francine Z., O'Brien, Brendan J. and Charchar, Fadi J.. 2014. "Exercise: putting action into our epigenome." Sports Medicine. 44 (2), pp. 189-209. https://doi.org/10.1007/s40279-013-0114-1
Leukocyte telomere length variation due to DNA extraction method
Denham, Joshua, Marques, Francine Z and Charchar, Fadi J. 2014. "Leukocyte telomere length variation due to DNA extraction method." BMC Research Notes. 7. https://doi.org/10.1186/1756-0500-7-877
Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors
Denham, Joshua, Nelson, Christopher P., O'Brien, Brendan J., Nankervis, Scott A., Denniff, Matthew, Harvey, Jack T., Marques, Francine Z., Codd, Veryan, Zukowska-Szczechowska, Ewa, Samani, Nilesh J., Tomaszewski, Maciej and Charchar, Fadi J.. 2013. "Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors." PLoS One. 8 (7). https://doi.org/10.1371/journal.pone.0069377