Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development

Article


Denham, Joshua, Gray, Adrian, Scott-Hamilton, John and Hagstrom, Amanda D.. 2018. "Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development." International Journal of Sports Medicine. 39 (1), pp. 67-72. https://doi.org/10.1055/s-0043-120763
Article Title

Sprint Interval Training Decreases Circulating MicroRNAs
Important for Muscle Development

ERA Journal ID9762
Article CategoryArticle
AuthorsDenham, Joshua (Author), Gray, Adrian (Author), Scott-Hamilton, John (Author) and Hagstrom, Amanda D. (Author)
Journal TitleInternational Journal of Sports Medicine
Journal Citation39 (1), pp. 67-72
Number of Pages6
Year2018
PublisherGeorg Thieme
Place of PublicationGermany
ISSN0172-4622
1439-3964
Digital Object Identifier (DOI)https://doi.org/10.1055/s-0043-120763
Web Address (URL)https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-120763
Abstract

Small non-coding RNAs, such as microRNAs (miRNAs), have emerged as powerful post-transcriptional regulators of gene expression that play important roles in many developmental and biological processes. In this study, we assessed the abundance of circulating microRNAs important for skeletal muscle and heart adaptations to exercise (miR-1, miR-133a, miR-133b and miR-486), following acute exercise and short-term sprint interval training (SIT). Twenty-eight individuals completed four all-out efforts on a cycle ergometer, and donated blood before and 30 min after the cessation of exercise. A subset of 10 untrained men completed 4-6 efforts of SIT, three times a week for 6 weeks, and donated resting blood samples before and after the intervention. MiRNA TaqMan qPCR was performed and whilst no changes were observed after a single session of SIT (all p>0.05), the 6-wk SIT intervention significantly reduced the whole blood content of all four miRNAs (mean fold-changes: 0.37-0.48, all p<0.01). Our data suggests that circulating miRNAs are responsive to short-term SIT and could have roles in SIT-induced health and performance adaptations. Further work is required to establish whether circulating miRNAs could serve as biomarkers for predicting exercise training responses and monitoring exercise interventions.

Keywordscardiorespiratory fitness; epigenetics; exercise; HIIT; myomiR; non-coding RNA
ANZSRC Field of Research 2020310599. Genetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsUniversity of New England
Institution of OriginUniversity of Southern Queensland
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