Time-restricted feeding influences immune responses without compromising muscle performance in older men

Article

Gasmi, Maha, Sellami, Maha, Denham, Joshua, Padulo, Johnny, Kuvacic, Goran, Selmi, Walid and Khalifa, Riadh. 2018. "Time-restricted feeding influences immune responses without compromising muscle performance in older men." Nutrition. 51-52, pp. 20-37. https://doi.org/10.1016/j.nut.2017.12.014
Article Title

Time-restricted feeding influences immune responses without
compromising muscle performance in older men

ERA Journal ID13728
Article CategoryArticle
AuthorsGasmi, Maha (Author), Sellami, Maha (Author), Denham, Joshua (Author), Padulo, Johnny (Author), Kuvacic, Goran (Author), Selmi, Walid (Author) and Khalifa, Riadh (Author)
Journal TitleNutrition
Journal Citation51-52, pp. 20-37
Number of Pages9
Year2018
Place of PublicationUnited States
ISSN0899-9007
1873-1244
Digital Object Identifier (DOI)https://doi.org/10.1016/j.nut.2017.12.014
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0899900718300364
Abstract

Objective: This study examined the effect of 12 wk of time-restricted feeding (TRF) on complete blood cell counts, natural killer cells, and muscle performance in 20- and 50-year-old men. Methods: Forty active and healthy participants were randomly divided into young experimental, young control, aged experimental, and aged control group. Experimental groups participated in TRF. Before (P1) and after (P2) TRF, participants performed a maximal exercise test to quantify muscle power. Resting venous blood samples were collected for blood count calculation. Results: No changes were identified in muscle power in all groups after TRF (P > 0.05). At P1, red cells, hemoglobin, and hematocrit were significantly higher in young participants compared with elderly participants (P < 0.05). At P2, this age effect was not found in red cells between the young experimental group and the aged experimental group (P > 0.05). At P1, white blood cells and neutrophils were significantly higher in young participants compared with elderly participants (P < 0.05). At P2, only neutrophils decreased significantly (P < 0.05) in experimental groups without significant (P > 0.05) difference among them. Lymphocytes decreased significantly in the aged experimental group at P2 (P < 0.05), whereas NKCD16+ and NKCD56+ decreased significantly in experimental groups at P2 (P < 0.05). TRF had no effect on CD3, CD4+, and CD8+ levels (P > 0.05). Conclusion: TRF decreases hematocrit, total white blood cells, lymphocytes, and neutrophils in young and older men. TRF may be effective in preventing inflammation by decreasing natural killer cells. As such, TRF could be a lifestyle strategy to reduce systemic low-grade inflammation and age-related chronic diseases linked to immunosenescence, without compromising physical performance.

KeywordsCaloric restriction, inflammation; Cytotoxic T cells; Immunosenescence; Natural killer T cells; Red cells; T cells
ANZSRC Field of Research 2020321006. Sport and exercise nutrition
420702. Exercise physiology
Byline AffiliationsUniversity of Manouba, Tunisia
University of Split, Croatia
University of New England
Institution of OriginUniversity of Southern Queensland
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