Age-associated telomere shortening in Thoroughbred horses

Article

Denham, Joshua, Stevenson, Kim and Denham, Michele M.. 2019. "Age-associated telomere shortening in Thoroughbred horses." Experimental Gerontology. 127, pp. 1-3. https://doi.org/10.1016/j.exger.2019.110718
Article Title

Age-associated telomere shortening in Thoroughbred horses

ERA Journal ID16117
Article CategoryArticle
AuthorsDenham, Joshua (Author), Stevenson, Kim (Author) and Denham, Michele M. (Author)
Journal TitleExperimental Gerontology
Journal Citation127, pp. 1-3
Article Number110718
Number of Pages3
Year2019
Place of PublicationUnited States
ISSN0531-5565
1873-6815
Digital Object Identifier (DOI)https://doi.org/10.1016/j.exger.2019.110718
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0531556519302499
Abstract

Telomeres are genetically conserved repetitive terminal DNA that protect against genomic instability and shorten with ageing. Here, we reveal the leukocyte telomere length of Equus caballus by measuring terminal restriction fragments (TRFs) using Southern Blot analysis in a cohort of 43 Thoroughbred horses (age: 24 h–25 years). Heterogeneous TRFs were observed in each animal and large inter-animal variation in mean TRF was observed (range: 10.5–18.7 kbp). Mean TRFs were inversely correlated with age (r = −0.47). The estimated yearly rate of telomere attrition was 134 bp. Horses should be considered as an alternative animal model to investigate environmental and lifestyle factors that regulate telomeres and promote healthy ageing.

KeywordsAgeing; Biological ageing; Equus caballus; Racehorse; Telomeres
ANZSRC Field of Research 2020310599. Genetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsRoyal Melbourne Institute of Technology (RMIT)
Jubilee Stud, Australia
Institution of OriginUniversity of Southern Queensland
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