Age-associated telomere shortening in Thoroughbred horses
Article
Article Title | Age-associated telomere shortening in Thoroughbred horses |
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ERA Journal ID | 16117 |
Article Category | Article |
Authors | Denham, Joshua (Author), Stevenson, Kim (Author) and Denham, Michele M. (Author) |
Journal Title | Experimental Gerontology |
Journal Citation | 127, pp. 1-3 |
Article Number | 110718 |
Number of Pages | 3 |
Year | 2019 |
Place of Publication | United States |
ISSN | 0531-5565 |
1873-6815 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.exger.2019.110718 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S0531556519302499 |
Abstract | Telomeres are genetically conserved repetitive terminal DNA that protect against genomic instability and shorten with ageing. Here, we reveal the leukocyte telomere length of Equus caballus by measuring terminal restriction fragments (TRFs) using Southern Blot analysis in a cohort of 43 Thoroughbred horses (age: 24 h–25 years). Heterogeneous TRFs were observed in each animal and large inter-animal variation in mean TRF was observed (range: 10.5–18.7 kbp). Mean TRFs were inversely correlated with age (r = −0.47). The estimated yearly rate of telomere attrition was 134 bp. Horses should be considered as an alternative animal model to investigate environmental and lifestyle factors that regulate telomeres and promote healthy ageing. |
Keywords | Ageing; Biological ageing; Equus caballus; Racehorse; Telomeres |
ANZSRC Field of Research 2020 | 310599. Genetics not elsewhere classified |
420702. Exercise physiology | |
Byline Affiliations | Royal Melbourne Institute of Technology (RMIT) |
Jubilee Stud, Australia | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6q58/age-associated-telomere-shortening-in-thoroughbred-horses
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