Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training
Article
Article Title | Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training |
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ERA Journal ID | 16583 |
Article Category | Article |
Authors | Dev, Prasun Kumar (Author), Gray, Adrian J. (Author), Scott-Hamilton, John (Author), Hagstrom, Amanda D. (Author), Murphy, Aron (Author) and Denham, Joshua (Author) |
Journal Title | Mechanisms of Ageing and Development |
Journal Citation | 199 |
Article Number | 111552 |
Number of Pages | 13 |
Year | 2021 |
Place of Publication | Ireland |
ISSN | 0047-6374 |
1872-6216 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mad.2021.111552 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S004763742100124X?via%3Dihub |
Abstract | Exercise training seems to promote healthy biological ageing partly by inducing telomere maintenance, yet the molecular mechanisms are not fully understood. Recent studies have emphasised the importance of microRNAs (miRNAs) in ageing and their ability to mirror pathophysiological alterations associated with age-related dis- eases. We examined the association between aerobic fitness and leukocyte telomere length before determining the influence of vigorous exercise training on the regulation of leukocyte miRNA networks. Telomere length was positively correlated to aerobic fitness (r = 0.32, p = 0.02). 104 miRNAs were differentially expressed after six weeks of thrice-weekly sprint interval training (SIT) in healthy men (q < 0.05). Gene co-expression analysis (WGCNA) detected biologically meaningful miRNA networks, five of which were significantly correlated with pre-SIT and post-SIT expression profiles (p < 0.001) and telomere length. Enrichment analysis revealed that the immune response, T cell differentiation and lipid metabolism associated miRNAs clusters were significantly down-regulated after SIT. Using data acquired from the Gene Expression Omnibus (GEO), we also identified two co-expressed miRNAs families that were modulated by exercise training in previous investigations. Collectively, our findings highlight the miRNA networks implicated in exercise adaptations and telomere regulation, and suggest that SIT may attenuate biological ageing through the control of the let-7 and miR-320 miRNA families. |
Keywords | small non-coding RNA, exercise training, telomere length, gene, WGCNA |
ANZSRC Field of Research 2020 | 420799. Sports science and exercise not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Central University of South Bihar, India |
University of New England | |
University of New South Wales | |
Royal Melbourne Institute of Technology (RMIT) | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6q50/co-expression-analysis-identifies-networks-of-mirnas-implicated-in-biological-ageing-and-modulated-by-short-term-interval-training
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