Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans

Article

Denham, Josh, O'Brien, Brendan J, Harvey, Jack T and Charchar, Fadi J. 2015. "Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans." Epigenomics. 7 (5). https://doi.org/10.2217/epi.15.29
Article Title

Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans

ERA Journal ID210428
Article CategoryArticle
AuthorsDenham, Josh, O'Brien, Brendan J, Harvey, Jack T and Charchar, Fadi J
Journal TitleEpigenomics
Journal Citation7 (5)
Number of Pages15
Year2015
PublisherFuture Medicine Ltd
Place of PublicationUnited Kingdom
ISSN1750-1911
1750-192X
Digital Object Identifier (DOI)https://doi.org/10.2217/epi.15.29
Web Address (URL)https://www.futuremedicine.com/doi/abs/10.2217/epi.15.29
Abstract

Aim: DNA methylation programs gene expression and is involved in numerous biological processes. Accumulating evidence supports transgenerational inheritance of DNA methylation changes in mammals via germ cells. Our aim was to determine the effect of exercise on sperm DNA methylation. Materials & methods: Twenty-four men were recruited and assigned to an exercise intervention or control group. Clinical parameters were measured and sperm samples were donated by subjects before and after the 3-month time-period. Mature sperm global and genome-wide DNA methylation was assessed using an ELISA assay and the 450K BeadChip (Illumina). Results: Global and genome-wide sperm DNA methylation was altered after 3 months of exercise training. DNA methylation changes occurred in genes related to numerous diseases such as schizophrenia and Parkinson's disease. Conclusions: Our study provides the first evidence showing exercise training reprograms the sperm methylome. Whether these DNA methylation changes are inherited to future generations warrants attention.

Keywordstransgenerational inheritance; disease risk; sperm; epigenetics
ANZSRC Field of Research 2020310504. Epigenetics (incl. genome methylation and epigenomics)
420702. Exercise physiology
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The accessible file is the accepted version of the paper. Please refer to the URL for the published version.

Byline AffiliationsFederation University
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