Exercise: putting action into our epigenome

Article


Denham, Josh, Marques, Francine Z., O'Brien, Brendan J. and Charchar, Fadi J.. 2014. "Exercise: putting action into our epigenome." Sports Medicine. 44 (2), pp. 189-209. https://doi.org/10.1007/s40279-013-0114-1
Article Title

Exercise: putting action into our epigenome

ERA Journal ID9811
Article CategoryArticle
AuthorsDenham, Josh, Marques, Francine Z., O'Brien, Brendan J. and Charchar, Fadi J.
Journal TitleSports Medicine
Journal Citation44 (2), pp. 189-209
Number of Pages21
Year2014
PublisherSpringer
Place of PublicationNew Zealand
ISSN0112-1642
1179-2035
Digital Object Identifier (DOI)https://doi.org/10.1007/s40279-013-0114-1
Web Address (URL)https://link.springer.com/article/10.1007/s40279-013-0114-1
Abstract

Most human phenotypes are influenced by a combination of genomic and environmental factors. Engaging in regular physical exercise prevents many chronic diseases, decreases mortality risk and increases longevity. However, the mechanisms involved are poorly understood. The modulating effect of physical (aerobic and resistance) exercise on gene expression has been known for some time now and has provided us with an understanding of the biological responses to physical exercise. Emerging research data suggest that epigenetic modifications are extremely important for both development and disease in humans. In the current review, we summarise findings on the effect of exercise on epigenetic modifications and their effects on gene expression. Current research data suggest epigenetic modifications (DNA methylation and histone acetylation) and microRNAs (miRNAs) are responsive to acute aerobic and resistance exercise in brain, blood, skeletal and cardiac muscle, adipose tissue and even buccal cells. Six months of aerobic exercise alters whole-genome DNA methylation in skeletal muscle and adipose tissue and directly influences lipogenesis. Some miRNAs are related to maximal oxygen consumption (VO2max) and VO2max trainability, and are differentially expressed amongst individuals with high and low VO2max. Remarkably, miRNA expression profiles discriminate between low and high responders to resistance exercise (miR-378, -26a, -29a and -451) and correlate to gains in lean body mass (miR-378). The emerging field of exercise epigenomics is expected to prosper and additional studies may elucidate the clinical relevance of miRNAs and epigenetic modifications, and delineate mechanisms by which exercise confers a healthier phenotype and improves performance.

ANZSRC Field of Research 2020310504. Epigenetics (incl. genome methylation and epigenomics)
310505. Gene expression (incl. microarray and other genome-wide approaches)
420702. Exercise physiology
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsFederation University
Permalink -

https://research.usq.edu.au/item/yzx8z/exercise-putting-action-into-our-epigenome

  • 17
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Exercise training reduces arterial stiffness in women with high blood pressure: a systematic review and meta-analysis
Zaman, Shadman, Selva Raj, Isaac, Yang, Angela Wei Hong, Lindner, Robert and Denham, Joshua. 2024. "Exercise training reduces arterial stiffness in women with high blood pressure: a systematic review and meta-analysis." Journal of Hypertension. 42 (2), pp. 197-204. https://doi.org/10.1097/HJH.0000000000003594
Coconut Water: A Sports Drink Alternative?
O'Brien, Brendan J., Bell, Leo R., Hennessy, Declan, Denham, Joshua and Paton, Carl D.. 2023. "Coconut Water: A Sports Drink Alternative?" Sports. 11 (9). https://doi.org/10.3390/sports11090183
The Emerging Role of Hypoxic Training for the Equine Athlete
Davie, Allan, Beavers, Rosalind, Hargitaiová, Kristýna and Denham, Joshua. 2023. "The Emerging Role of Hypoxic Training for the Equine Athlete." Animals. 13 (17). https://doi.org/10.3390/ani13172799
A student-run exercise physiology clinic in Australia: who and what do we see?
Hume, E., Cameron, M., Findley, I., Smart, S., Elisaia, C., Hulme, A., Mills, D. and Denham, J.. 2023. "A student-run exercise physiology clinic in Australia: who and what do we see? " 2023 ASICS SMA Conference (ASICS SMA 2023). Sunshine Coast, Australia 11 - 14 Oct 2023 Australia. Elsevier. https://doi.org/10.1016/j.jsams.2023.08.107
Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis
Lindner, Robert, Selva Raj, Isaac, Yang, Angela Wei Hong, Zaman, Shadman, Larsen, Brianna and Denham, Joshua. 2023. "Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis." International Journal of Sports Medicine. 44 (7), pp. 484-495. https://doi.org/10.1055/a-2044-8952
Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training
Denham, Josh. 2023. "Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training." Aging Cell. 22 (6). https://doi.org/10.1111/acel.13836
Exercise regulates shelterin genes and microRNAs implicated in ageing in Thoroughbred horses
Mandal, Shama, Denham, Michele M., Spencer, Sarah J. and Denham, Joshua. 2022. "Exercise regulates shelterin genes and microRNAs implicated in ageing in Thoroughbred horses." Pfugers Archiv: European journal of physiology. 474 (11), p. 1159–1169. https://doi.org/10.1007/s00424-022-02745-0
Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training
Denham, Joshua, O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training." Sports Medicine. 46 (9), pp. 1213-1237. https://doi.org/10.1007/s40279-016-0482-4
Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness
Denham, Joshua and Prestes, Priscilla R.. 2016. "Muscle-Enriched MicroRNAs Isolated from Whole Blood Are Regulated by Exercise and Are Potential Biomarkers of Cardiorespiratory Fitness." Frontiers in Genetics. 7, pp. 1-8. https://doi.org/10.3389/fgene.2016.00196
Epigenetic changes in leukocytes after 8 weeks of resistance exercise training
Denham, Joshua, Marques, Francine Z., Bruns, Emma L., O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Epigenetic changes in leukocytes after 8 weeks of resistance exercise training." European Journal of Applied Physiology. 116 (6), pp. 1245-1253. https://doi.org/10.1007/s00421-016-3382-2
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres
Denham, Joshua, O'Brien, Brendan J., Prestes, Priscilla R., Brown, Nicholas J. and Charchar, Fadi J.. 2016. "Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres." Journal of Applied Physiology. 120 (2), pp. 148-158. https://doi.org/10.1152/japplphysiol.00587.2015
Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness
Denham, Joshua, Brown, Nicholas J., Tomaszewski, Maciej, Williams, Bryan, O'Brien, Brendan J. and Charchar, Fadi J.. 2016. "Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness." European Journal of Applied Physiology. 116 (8), pp. 1537-1544. https://doi.org/10.1007/s00421-016-3407-x
Lack of association between PBMC telomere length and endurance exercise
Denham, Joshua. 2017. "Lack of association between PBMC telomere length and endurance exercise." Journal of Applied Biomedicine. 15 (1), pp. 9-13. https://doi.org/10.1016/j.jab.2016.09.004
Exercise and epigenetic inheritance of disease risk
Denham, Joshua. 2018. "Exercise and epigenetic inheritance of disease risk." Acta Physiologica. 222 (1), pp. 1-20. https://doi.org/10.1111/apha.12881
Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development
Denham, Joshua, Gray, Adrian, Scott-Hamilton, John and Hagstrom, Amanda D.. 2018. "Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development." International Journal of Sports Medicine. 39 (1), pp. 67-72. https://doi.org/10.1055/s-0043-120763
Time-restricted feeding influences immune responses without compromising muscle performance in older men
Gasmi, Maha, Sellami, Maha, Denham, Joshua, Padulo, Johnny, Kuvacic, Goran, Selmi, Walid and Khalifa, Riadh. 2018. "Time-restricted feeding influences immune responses without compromising muscle performance in older men." Nutrition. 51-52, pp. 20-37. https://doi.org/10.1016/j.nut.2017.12.014
microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors
Hagstrom, Amanda D. and Denham, Joshua. 2018. "microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors." International Journal of Sports Medicine. 39 (6), pp. 482-489. https://doi.org/10.1055/a-0592-7691
Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?
Sellami, Maha, Gasmi, Maha, Denham, Joshua, Hayes, Lawrence D., Stratton, Dan, Padulo, Johnny and Bragazzi, Nicola. 2018. "Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?" Frontiers in Immunology. 9, pp. 1-17. https://doi.org/10.3389/fimmu.2018.02187
The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer
Hagstrom, Amanda D. and Denham, Joshua. 2018. "The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer." Journal of Functional Morphology and Kinesiology. 3 (1), pp. 1-7. https://doi.org/10.3390/jfmk3010009
Small non-coding RNAs are altered by short-term sprint interval training in men
Denham, Joshua, Gray, Adrian J., Scott-Hamilton, John, Hagstrom, Amanda D. and Murphy, Aron J.. 2018. "Small non-coding RNAs are altered by short-term sprint interval training in men." Physiological Reports. 6 (7), pp. 1-10. https://doi.org/10.14814/phy2.13653
Leukocyte telomere length in the Thoroughbred racehorse
Denham, Josh and Denham, Michele M.. 2018. "Leukocyte telomere length in the Thoroughbred racehorse." Animal Genetics. 49 (5), pp. 452-456. https://doi.org/10.1111/age.12681
Age-associated telomere shortening in Thoroughbred horses
Denham, Joshua, Stevenson, Kim and Denham, Michele M.. 2019. "Age-associated telomere shortening in Thoroughbred horses." Experimental Gerontology. 127, pp. 1-3. https://doi.org/10.1016/j.exger.2019.110718
The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans
Denham, Joshua. 2019. "The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans." Biomedical journal. 42 (6), pp. 430-433. https://doi.org/10.1016/j.bj.2019.07.003
Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan
Hiam, Danielle, Smith, Cassandra, Voisin, Sarah, Denham, Josh, Yan, Xu, Landen, Shanie, Jacques, Macsue, Alvarez-Romero, Javier, Garnham, Andrew, Woessner, Mary N., Herrmann, Markus, Duque, Gustavo, Levinger, Itamar and Eynon, Nir. 2020. "Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan." Aging. 12 (1), pp. 359-369. https://doi.org/10.18632/aging.102627
Telomere regulation: lessons learnt from mice and men, potential opportunities in horses
Denham, Josh. 2020. "Telomere regulation: lessons learnt from mice and men, potential opportunities in horses." Animal Genetics. 51 (1), pp. 3-13. https://doi.org/10.1111/age.12870
Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations
Denham, Josh and Spencer, Sarah J.. 2020. "Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations." American Journal of Physiology: Endocrinology and Metabolism. 319 (2), pp. E320-E329. https://doi.org/10.1152/ajpendo.00215.2020
A Systematic Review and Meta-analysis on Sodium Bicarbonate Administration and Equine Running Performance: Is it Time to Stop Horsing Around With Baking Soda?
Denham, Joshua and Hulme, Adam. 2020. "A Systematic Review and Meta-analysis on Sodium Bicarbonate Administration and Equine Running Performance: Is it Time to Stop Horsing Around With Baking Soda?" Journal of Equine Veterinary Science. 95, pp. 1-7. https://doi.org/10.1016/j.jevs.2020.103281
Cycling power outputs predict functional threshold power and maximum oxygen uptake
Denham, Joshua, Scott-Hamilton, John, Hagstrom, Amanda D. and Gray, Adrian J.. 2021. "Cycling power outputs predict functional threshold power and maximum oxygen uptake." Journal of Strength and Conditioning Research. 34 (12), pp. 3489-3497. https://doi.org/10.1519/jsc.0000000000002253
Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a lifetime
Sellami, Maha, Bragazzi, Nicola, Prince, Mohammad Shoaib, Denham, Joshua and Elrayess, Mohamed. 2021. "Regular, intense exercise training as a healthy aging lifestyle strategy: preventing DNA damage, telomere shortening and adverse DNA methylation changes over a lifetime." Frontiers in Genetics. 12, pp. 1-12. https://doi.org/10.3389/fgene.2021.652497
Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
Nakai, Michael E., Denham, Joshua, Prestes, Priscilla R., Eikelis, Nina, Lambert, Elizabeth A., Straznicky, Nora E., Schlaich, Markus P., Esler, Murray D., O'Brien, Brendan J., Charchar, Fadi J., Lambert, Gavin W. and Marques, Francine Z.. 2021. "Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting." Scientific Reports. 11 (1), pp. 1-12. https://doi.org/10.1038/s41598-021-83472-x
Epigenetic control of exercise adaptations in the equine athlete: current evidence and future directions
Denham, Joshua, McCluskey, Michael, Denham, Michele M., Sellami, Maha and Davie, Alan J.. 2021. "Epigenetic control of exercise adaptations in the equine athlete: current evidence and future directions." Equine Veterinary Journal. 53 (3), pp. 431-450. https://doi.org/10.1111/evj.13320
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis
Denham, Joshua and Sellami, Maha. 2021. "Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: a systematic review and meta-analysis." Ageing Research Reviews. 70. https://doi.org/10.1016/j.arr.2021.101411
Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training
Dev, Prasun Kumar, Gray, Adrian J., Scott-Hamilton, John, Hagstrom, Amanda D., Murphy, Aron and Denham, Joshua. 2021. "Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training." Mechanisms of Ageing and Development. 199. https://doi.org/10.1016/j.mad.2021.111552
Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise
Denham, Joshua, O'Brien, Brendan J., Marques, Francine Z. and Charchar, Fadi J.. 2015. "Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise." Journal of Applied Physiology. 118 (4), pp. 475-488. https://doi.org/10.1152/japplphysiol.00878.2014
Four weeks of sprint interval training improves 5-km run performance
Denham, Joshua, Feros, Simon A and O'Brien, Brendan J.. 2015. "Four weeks of sprint interval training improves 5-km run performance." Journal of Strength and Conditioning Research. 29 (8), pp. 2137-2141. https://doi.org/10.1519/JSC.0000000000000862
Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans
Denham, Josh, O'Brien, Brendan J, Harvey, Jack T and Charchar, Fadi J. 2015. "Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans." Epigenomics. 7 (5). https://doi.org/10.2217/epi.15.29
Leukocyte telomere length variation due to DNA extraction method
Denham, Joshua, Marques, Francine Z and Charchar, Fadi J. 2014. "Leukocyte telomere length variation due to DNA extraction method." BMC Research Notes. 7. https://doi.org/10.1186/1756-0500-7-877
Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors
Denham, Joshua, Nelson, Christopher P., O'Brien, Brendan J., Nankervis, Scott A., Denniff, Matthew, Harvey, Jack T., Marques, Francine Z., Codd, Veryan, Zukowska-Szczechowska, Ewa, Samani, Nilesh J., Tomaszewski, Maciej and Charchar, Fadi J.. 2013. "Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors." PLoS One. 8 (7). https://doi.org/10.1371/journal.pone.0069377