microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors
Article
Article Title | microRNAs in High and Low Responders to Resistance Training in |
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ERA Journal ID | 9762 |
Article Category | Article |
Authors | Hagstrom, Amanda D. (Author) and Denham, Joshua (Author) |
Journal Title | International Journal of Sports Medicine |
Journal Citation | 39 (6), pp. 482-489 |
Number of Pages | 8 |
Year | 2018 |
Publisher | Georg Thieme |
Place of Publication | Germany |
ISSN | 0172-4622 |
1439-3964 | |
Digital Object Identifier (DOI) | https://doi.org/10.1055/a-0592-7691 |
Web Address (URL) | https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0592-7691 |
Abstract | Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention. The resistance training group completed supervised thrice-weekly training. miRNA abundance was assessed before and after the intervention period using qPCR. There were no statistically significant changes in any of the miRNAs between groups after the intervention period (all p>0.05). After assessing miRNA abundance in context with high and low responders to resistance training, we observed that relative to low responders, high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p. Findings from our controlled study indicate the diverse interindividual miRNA responses to resistance training and reveal a discordant regulation between high and low responders. |
Keywords | exercise; miRNA; miRNA-133a; muscle strength; small non-coding RNA |
ANZSRC Field of Research 2020 | 310599. Genetics not elsewhere classified |
420702. Exercise physiology | |
Byline Affiliations | University of New England |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6q5y/micrornas-in-high-and-low-responders-to-resistance-training-in-breast-cancer-survivors
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