microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors

Article


Hagstrom, Amanda D. and Denham, Joshua. 2018. "microRNAs in High and Low Responders to Resistance Training in Breast Cancer Survivors." International Journal of Sports Medicine. 39 (6), pp. 482-489. https://doi.org/10.1055/a-0592-7691
Article Title

microRNAs in High and Low Responders to Resistance Training in
Breast Cancer Survivors

ERA Journal ID9762
Article CategoryArticle
AuthorsHagstrom, Amanda D. (Author) and Denham, Joshua (Author)
Journal TitleInternational Journal of Sports Medicine
Journal Citation39 (6), pp. 482-489
Number of Pages8
Year2018
PublisherGeorg Thieme
Place of PublicationGermany
ISSN0172-4622
1439-3964
Digital Object Identifier (DOI)https://doi.org/10.1055/a-0592-7691
Web Address (URL)https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0592-7691
Abstract

Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention. The resistance training group completed supervised thrice-weekly training. miRNA abundance was assessed before and after the intervention period using qPCR. There were no statistically significant changes in any of the miRNAs between groups after the intervention period (all p>0.05). After assessing miRNA abundance in context with high and low responders to resistance training, we observed that relative to low responders, high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p. Findings from our controlled study indicate the diverse interindividual miRNA responses to resistance training and reveal a discordant regulation between high and low responders.

Keywordsexercise; miRNA; miRNA-133a; muscle strength; small non-coding RNA
ANZSRC Field of Research 2020310599. Genetics not elsewhere classified
420702. Exercise physiology
Byline AffiliationsUniversity of New England
Institution of OriginUniversity of Southern Queensland
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